Matrix metalloproteinase-9 is increased in obese subjects and decreases in response to pioglitazone

The study investigated the regulation of matrix metalloproteinases (MMP)-9 in obesity-associated insulin resistance in humans. The objectives of the investigation were to study MMP-9 regulation by insulin resistance and pioglitazone treatment in impaired glucose tolerant subjects using adipose tissu...

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Vydané v:	The journal of clinical endocrinology and metabolism Ročník 95; číslo 6; s. 2993
Hlavní autori:	Unal, Resat, Yao-Borengasser, Aiwei, Varma, Vijayalakshmi, Rasouli, Neda, Labbate, Craig, Kern, Philip A, Ranganathan, Gouri
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.06.2010
Predmet:	Adipocytes - drug effects Adipocytes - enzymology Adipose Tissue - enzymology Adult Aged Blotting, Western Body Mass Index Cells, Cultured Coculture Techniques Female Humans Hypoglycemic Agents - therapeutic use Insulin Resistance Male Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase Inhibitors Middle Aged Obesity - enzymology Oligonucleotides - metabolism Pioglitazone Protein Kinase C-alpha - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA - biosynthesis RNA - genetics Stromal Cells - drug effects Stromal Cells - enzymology Th1 Cells - drug effects Th1 Cells - enzymology Thiazolidinediones - therapeutic use Transfection Young Adult
ISSN:	1945-7197, 1945-7197
On-line prístup:	Zistit podrobnosti o prístupe
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