Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression

Preclinical and clinical studies suggest that inflammation and vascular dysfunction contribute to the pathogenesis of major depressive disorder (MDD). Chronic social stress alters blood-brain barrier (BBB) integrity through loss of tight junction protein claudin-5 (cldn5) in male mice, promoting pas...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 117; číslo 6; s. 3326
Hlavní autori:	Dudek, Katarzyna A, Dion-Albert, Laurence, Lebel, Manon, LeClair, Katherine, Labrecque, Simon, Tuck, Ellen, Ferrer Perez, Carmen, Golden, Sam A, Tamminga, Carol, Turecki, Gustavo, Mechawar, Naguib, Russo, Scott J, Menard, Caroline
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 11.02.2020
Predmet:	Animals Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Blood-Brain Barrier - metabolism Claudin-5 - metabolism Depression - drug therapy Depression - metabolism Depressive Disorder, Major - metabolism Disease Models, Animal Epigenesis, Genetic - drug effects Epigenesis, Genetic - physiology Histone Deacetylase 1 - metabolism Humans Inflammation - metabolism Male Mice Mice, Inbred C57BL Nucleus Accumbens - metabolism Signal Transduction - drug effects Signal Transduction - physiology Stress, Psychological - metabolism epigenetic inflammation vascular mood disorders antidepressant
ISSN:	1091-6490, 1091-6490
On-line prístup:	Zistit podrobnosti o prístupe
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