Ultrasensitive multispecies spectroscopic breath analysis for real-time health monitoring and diagnostics
Breath analysis enables rapid, noninvasive diagnostics, as well as long-term monitoring of human health, through the identification and quantification of exhaled biomarkers. Here, we demonstrate the remarkable capabilities of mid-infrared (mid-IR) cavity-enhanced direct-frequency comb spectroscopy (...
Uloženo v:
| Vydáno v: | Proceedings of the National Academy of Sciences - PNAS Ročník 118; číslo 40 |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
05.10.2021
|
| Témata: | |
| ISSN: | 1091-6490, 1091-6490 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Breath analysis enables rapid, noninvasive diagnostics, as well as long-term monitoring of human health, through the identification and quantification of exhaled biomarkers. Here, we demonstrate the remarkable capabilities of mid-infrared (mid-IR) cavity-enhanced direct-frequency comb spectroscopy (CE-DFCS) applied to breath analysis. We simultaneously detect and monitor as a function of time four breath biomarkers-[Formula: see text]OH, [Formula: see text], [Formula: see text]O, and HDO-as well as illustrate the feasibility of detecting at least six more ([Formula: see text]CO, [Formula: see text], OCS, [Formula: see text], [Formula: see text], and [Formula: see text]) without modifications to the experimental apparatus. We achieve ultrahigh detection sensitivity at the parts-per-trillion level. This is made possible by the combination of the broadband spectral coverage of a frequency comb, the high spectral resolution afforded by the individual comb teeth, and the sensitivity enhancement resulting from a high-finesse cavity. Exploiting recent advances in frequency comb, optical coating, and photodetector technologies, we can access a large variety of biomarkers with strong carbon-hydrogen-bond spectral signatures in the mid-IR. |
|---|---|
| AbstractList | Breath analysis enables rapid, noninvasive diagnostics, as well as long-term monitoring of human health, through the identification and quantification of exhaled biomarkers. Here, we demonstrate the remarkable capabilities of mid-infrared (mid-IR) cavity-enhanced direct-frequency comb spectroscopy (CE-DFCS) applied to breath analysis. We simultaneously detect and monitor as a function of time four breath biomarkers-[Formula: see text]OH, [Formula: see text], [Formula: see text]O, and HDO-as well as illustrate the feasibility of detecting at least six more ([Formula: see text]CO, [Formula: see text], OCS, [Formula: see text], [Formula: see text], and [Formula: see text]) without modifications to the experimental apparatus. We achieve ultrahigh detection sensitivity at the parts-per-trillion level. This is made possible by the combination of the broadband spectral coverage of a frequency comb, the high spectral resolution afforded by the individual comb teeth, and the sensitivity enhancement resulting from a high-finesse cavity. Exploiting recent advances in frequency comb, optical coating, and photodetector technologies, we can access a large variety of biomarkers with strong carbon-hydrogen-bond spectral signatures in the mid-IR. Breath analysis enables rapid, noninvasive diagnostics, as well as long-term monitoring of human health, through the identification and quantification of exhaled biomarkers. Here, we demonstrate the remarkable capabilities of mid-infrared (mid-IR) cavity-enhanced direct-frequency comb spectroscopy (CE-DFCS) applied to breath analysis. We simultaneously detect and monitor as a function of time four breath biomarkers-[Formula: see text]OH, [Formula: see text], [Formula: see text]O, and HDO-as well as illustrate the feasibility of detecting at least six more ([Formula: see text]CO, [Formula: see text], OCS, [Formula: see text], [Formula: see text], and [Formula: see text]) without modifications to the experimental apparatus. We achieve ultrahigh detection sensitivity at the parts-per-trillion level. This is made possible by the combination of the broadband spectral coverage of a frequency comb, the high spectral resolution afforded by the individual comb teeth, and the sensitivity enhancement resulting from a high-finesse cavity. Exploiting recent advances in frequency comb, optical coating, and photodetector technologies, we can access a large variety of biomarkers with strong carbon-hydrogen-bond spectral signatures in the mid-IR.Breath analysis enables rapid, noninvasive diagnostics, as well as long-term monitoring of human health, through the identification and quantification of exhaled biomarkers. Here, we demonstrate the remarkable capabilities of mid-infrared (mid-IR) cavity-enhanced direct-frequency comb spectroscopy (CE-DFCS) applied to breath analysis. We simultaneously detect and monitor as a function of time four breath biomarkers-[Formula: see text]OH, [Formula: see text], [Formula: see text]O, and HDO-as well as illustrate the feasibility of detecting at least six more ([Formula: see text]CO, [Formula: see text], OCS, [Formula: see text], [Formula: see text], and [Formula: see text]) without modifications to the experimental apparatus. We achieve ultrahigh detection sensitivity at the parts-per-trillion level. This is made possible by the combination of the broadband spectral coverage of a frequency comb, the high spectral resolution afforded by the individual comb teeth, and the sensitivity enhancement resulting from a high-finesse cavity. Exploiting recent advances in frequency comb, optical coating, and photodetector technologies, we can access a large variety of biomarkers with strong carbon-hydrogen-bond spectral signatures in the mid-IR. |
| Author | Chan, Ya-Chu Toscano, Jutta Changala, P Bryan Ye, Jun Liang, Qizhong Nesbitt, David J |
| Author_xml | – sequence: 1 givenname: Qizhong surname: Liang fullname: Liang, Qizhong organization: Department of Physics, University of Colorado Boulder, Boulder, CO 80309 – sequence: 2 givenname: Ya-Chu surname: Chan fullname: Chan, Ya-Chu organization: Department of Chemistry, University of Colorado Boulder, Boulder, CO 80309 – sequence: 3 givenname: P Bryan orcidid: 0000-0003-0304-9814 surname: Changala fullname: Changala, P Bryan organization: Center for Astrophysics, Harvard College Observatory and Smithsonian Astrophysical Observatory, Cambridge, MA 02138 – sequence: 4 givenname: David J orcidid: 0000-0001-5365-1120 surname: Nesbitt fullname: Nesbitt, David J organization: Department of Chemistry, University of Colorado Boulder, Boulder, CO 80309 – sequence: 5 givenname: Jun orcidid: 0000-0003-0076-2112 surname: Ye fullname: Ye, Jun email: jutta.toscano@jila.colorado.edu, ye@jila.colorado.edu organization: Department of Physics, University of Colorado Boulder, Boulder, CO 80309 – sequence: 6 givenname: Jutta orcidid: 0000-0003-3594-9462 surname: Toscano fullname: Toscano, Jutta email: jutta.toscano@jila.colorado.edu, ye@jila.colorado.edu organization: Department of Physics, University of Colorado Boulder, Boulder, CO 80309 |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34599098$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkLtPwzAYxC1URB8wsyGPLCl24ueIKl5SJRY6R47ztTVK7GA7SP3vCQIkpjvd_XTDLdHMBw8IXVOypkRWd4M3aV1SwomoKFVnaEGJpoVgmsz--TlapvROCNFckQs0rxjXmmi1QG7X5WgS-OSy-wTcj112aQDrIOFvzTEkGwZncRPB5CM23nSn5BLeh4inqCuy6wEfJze1ffAuh-j8YQJb3Dpz8CFlZ9MlOt-bLsHVr67Q7vHhbfNcbF-fXjb328JyxnNR2VJQ2jZEcCPANppKQZhu9hyoEYZWRspG6lYrUMAYSKNFBSAMI_uStKpcoduf3SGGjxFSrnuXLHSd8RDGVJdcKimYUHpCb37RsemhrYfoehNP9d895RcifWwq |
| CitedBy_id | crossref_primary_10_1063_5_0218110 crossref_primary_10_1109_RBME_2024_3481360 crossref_primary_10_1021_acs_nanolett_4c06676 crossref_primary_10_1002_jbio_202300198 crossref_primary_10_3390_molecules28052320 crossref_primary_10_1063_5_0145194 crossref_primary_10_1016_j_aca_2025_344303 crossref_primary_10_1038_s41534_023_00758_w crossref_primary_10_1038_s43246_024_00480_w crossref_primary_10_1002_mop_33156 crossref_primary_10_1038_s41377_022_00947_w crossref_primary_10_1073_pnas_2105063118 crossref_primary_10_1016_j_saa_2024_124625 crossref_primary_10_1063_5_0167683 crossref_primary_10_1016_j_snb_2025_137422 crossref_primary_10_1016_j_snb_2022_132333 crossref_primary_10_1146_annurev_physchem_082423_013137 crossref_primary_10_1038_s41586_024_08534_2 crossref_primary_10_1016_j_nima_2023_168530 crossref_primary_10_1016_j_snb_2023_133690 crossref_primary_10_1088_1361_6501_acf1bb crossref_primary_10_1038_s41377_023_01096_4 crossref_primary_10_3390_rs15010069 crossref_primary_10_34133_ultrafastscience_0098 crossref_primary_10_1007_s00376_024_4209_4 crossref_primary_10_1016_j_smhl_2025_100579 crossref_primary_10_1038_s41598_022_05926_0 crossref_primary_10_1016_j_trac_2024_117865 crossref_primary_10_1063_5_0091263 crossref_primary_10_37349_emed_2025_1001308 crossref_primary_10_3390_s24041077 crossref_primary_10_1038_s41567_024_02423_1 crossref_primary_10_1063_5_0202641 crossref_primary_10_1073_pnas_2303928120 crossref_primary_10_1088_1752_7163_acc6e4 crossref_primary_10_1109_JLT_2023_3276769 crossref_primary_10_1088_1752_7163_ac70ef crossref_primary_10_3389_fonc_2022_975563 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1073/pnas.2105063118 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Sciences (General) |
| EISSN | 1091-6490 |
| ExternalDocumentID | 34599098 |
| Genre | Research Support, U.S. Gov't, Non-P.H.S Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- -DZ -~X .55 0R~ 123 29P 2AX 2FS 2WC 4.4 53G 5RE 5VS 85S AACGO AAFWJ AANCE ABBHK ABOCM ABPLY ABPPZ ABTLG ABXSQ ABZEH ACGOD ACIWK ACNCT ACPRK AENEX AEUPB AEXZC AFFNX AFOSN AFRAH ALMA_UNASSIGNED_HOLDINGS BKOMP CGR CS3 CUY CVF D0L DCCCD DIK DU5 E3Z EBS ECM EIF F5P FRP GX1 H13 HH5 HYE IPSME JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JST KQ8 L7B LU7 N9A NPM N~3 O9- OK1 PNE PQQKQ R.V RHI RNA RNS RPM RXW SA0 SJN TAE TN5 UKR W8F WH7 WOQ WOW X7M XSW Y6R YBH YKV YSK ZCA ~02 ~KM 7X8 |
| ID | FETCH-LOGICAL-c545t-3c2611db065a6ecb9176049bf5e1a6a13a77b79d98e8e44e7a963ee6a40f20d82 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 58 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000705930300005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1091-6490 |
| IngestDate | Fri Sep 05 12:47:54 EDT 2025 Thu Apr 03 06:53:08 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 40 |
| Keywords | breath analysis frequency combs spectroscopy |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c545t-3c2611db065a6ecb9176049bf5e1a6a13a77b79d98e8e44e7a963ee6a40f20d82 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-5365-1120 0000-0003-0076-2112 0000-0003-3594-9462 0000-0003-0304-9814 |
| OpenAccessLink | https://figshare.com/articles/preprint/Ultra-sensitive_multi-species_spectroscopic_breath_analysis_for_real-time_health_monitoring_and_diagnostics/21870444 |
| PMID | 34599098 |
| PQID | 2578764689 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2578764689 pubmed_primary_34599098 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-10-05 |
| PublicationDateYYYYMMDD | 2021-10-05 |
| PublicationDate_xml | – month: 10 year: 2021 text: 2021-10-05 day: 05 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Proceedings of the National Academy of Sciences - PNAS |
| PublicationTitleAlternate | Proc Natl Acad Sci U S A |
| PublicationYear | 2021 |
| SSID | ssj0009580 |
| Score | 2.6216788 |
| Snippet | Breath analysis enables rapid, noninvasive diagnostics, as well as long-term monitoring of human health, through the identification and quantification of... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| SubjectTerms | Biomarkers - metabolism Breath Tests - methods Humans Sensitivity and Specificity Spectrum Analysis - methods |
| Title | Ultrasensitive multispecies spectroscopic breath analysis for real-time health monitoring and diagnostics |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/34599098 https://www.proquest.com/docview/2578764689 |
| Volume | 118 |
| WOSCitedRecordID | wos000705930300005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NS8MwFA_qPHhR5-f8IoIHPcQ1bdomJxFxeHHs4GC3ka_iYLZ1nf79vqQZehEELy2UBErykvd7X7-H0JVScUwzoYgSMnWuG0GUdoSXFLSNEdYKw3yziXw45JOJGAWHWxPSKld3or-oTaWdj7zvRStjGRd39TtxXaNcdDW00FhHnQSgjJPqfMJ_kO7ylo1AUJIxEa2offKkX5eyuQVzJwUVTSn_HV96PTPY-e8f7qLtgDDxfSsSXbRmyz3UDWe4wdeBaPpmH83G8-UCtFjZ-AQi7JMLXeklWM_Yl2A6qsuqnmmsHLZ8xTJQmGCAuhg-zYnrTY_bYkr85u8H5yiEgQabNovP8UAfoPHg8eXhiYTWC0QDpFqSRINlRY0CgCIzqxUYdRnYEqpILZWZpInMc5ULI7jlljGbSzjI1maSRUUcGR4foo2yKu0xwrRgsN-UwiwFL81doDY3heAqErGOe-hytZxTEG0Xr5ClrT6a6feC9tBRuyfTuuXgmCYsBT0q-MkfZp-irdhloviw_xnqFHCw7Tna1J-wqIsLLzPwHI6evwD-Ec37 |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Ultrasensitive+multispecies+spectroscopic+breath+analysis+for+real-time+health+monitoring+and+diagnostics&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+-+PNAS&rft.au=Liang%2C+Qizhong&rft.au=Chan%2C+Ya-Chu&rft.au=Changala%2C+P+Bryan&rft.au=Nesbitt%2C+David+J&rft.date=2021-10-05&rft.issn=1091-6490&rft.eissn=1091-6490&rft.volume=118&rft.issue=40&rft_id=info:doi/10.1073%2Fpnas.2105063118&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1091-6490&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1091-6490&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1091-6490&client=summon |