Therapeutic Targeting of the IGF Axis

The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and development, and when deregulated makes an important contribution to disease. Here, we review the functions mediated by ligand-induced IGF axis activation, and discuss the evidence for the involvement of IGF sign...

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Bibliographic Details
Published in:	Cells (Basel, Switzerland) Vol. 8; no. 8; p. 895
Main Authors:	Osher, Eliot, Macaulay, Valentine M.
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 14.08.2019 MDPI
Subjects:	Acne Acromegaly Aging Aging - metabolism Animals Binding sites Biological activity Cancer Cancer therapies Diabetes mellitus Dwarfism Endocrine disorders Endocrine System Diseases - drug therapy Endocrine System Diseases - metabolism Eye diseases Gene amplification Growth factors Humans IGF IGF inhibitor IGF-1R Insulin Insulin-like growth factors Kinases Ligands Medical prognosis Metastasis Mice Molecular Targeted Therapy Mutation Neoplasms - drug therapy Neoplasms - metabolism ophthalmopathy Prostate cancer Proteins Psoriasis Rats Receptor, IGF Type 1 - antagonists & inhibitors Review Signal transduction Signal Transduction - drug effects Skin diseases Skin Diseases - drug therapy Skin Diseases - metabolism Somatomedins - antagonists & inhibitors Therapeutic targets Thyroid Tumors type 1 IGF receptor IGF inhibitor type 1 IGF receptor IGF ophthalmopathy acromegaly cancer IGF-1R
ISSN:	2073-4409, 2073-4409
Online Access:	Get full text
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