Effects of (−)-hydroxycitrate on net fat synthesis as de novo lipogenesis

(−)-Hydroxycitrate (HCA) might promote weight maintenance by limiting the capacity for de novo lipogenesis (DNL). It was investigated whether HCA may reduce DNL in humans during a persistent excess of energy intake as carbohydrate. In a double-blind, placebo-controlled, randomized and cross-over des...

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Vydané v:	Physiology & behavior Ročník 88; číslo 4; s. 371 - 381
Hlavní autori:	Kovacs, Eva M.R., Westerterp-Plantenga, Margriet S.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Cambridge Elsevier Inc 30.07.2006 New York, NY Elsevier
Predmet:	Adult Affect - drug effects Anthropometry Attitude Biological and medical sciences Body Composition - drug effects Body Weight Calorimetry, Indirect Citrates - pharmacology Cross-Over Studies Dietary Carbohydrates - pharmacology Double-Blind Method Energy metabolism Energy Metabolism - drug effects Exercise - physiology Fat synthesis Fundamental and applied biological sciences. Psychology Garcinia cambogia Glycogen - metabolism Humans Intermediate and energetic metabolism Lipid Metabolism - drug effects Lipids - biosynthesis Male Metabolisms and neurohumoral controls Overfeeding Oxidation-Reduction Respiratory Mechanics - physiology Substrate oxidation Vertebrates: anatomy and physiology, studies on body, several organs or systems Energy metabolism Fat synthesis Garcinia cambogia Substrate oxidation Overfeeding Human Placebo Double blind study Fat Oxidation Lipogenesis
ISSN:	0031-9384, 1873-507X
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Shrnutí:	(−)-Hydroxycitrate (HCA) might promote weight maintenance by limiting the capacity for de novo lipogenesis (DNL). It was investigated whether HCA may reduce DNL in humans during a persistent excess of energy intake as carbohydrate. In a double-blind, placebo-controlled, randomized and cross-over design, 10 sedentary lean male subjects (mean ± S.D., age: 24 ± 5 years, BMI: 21.8 ± 2.1 kg/m 2) performed a glycogen depletion exercise test followed by a 3-day high-fat diet (F/CHO/P, 60/25/15% energy; 100% of energy expenditure (EE)) and a 7-day high-CHO diet (F/CHO/P, < 5/> 85/10% energy; 130–175% of EE; overfeeding). During overfeeding, they ingested 3 × 500 mg/day HCA or placebo (PLA). Each intervention ended with a 60-h stay in the respiration chamber (days 9 and 10). Body weight increased during overfeeding (mean ± S.E., HCA: 2.9 ± 0.2 kg, PLA: 2.8 ± 0.2 kg). Respiratory quotient (RQ) was > 1.00 in all subjects indicating that DNL was present. On day 9, 24-h EE was lower with HCA compared to PLA ( P < 0.05). On day 10, resting metabolic rate and RQ during night were lower ( P < 0.01 and P < 0.05, respectively). Non-protein RQ, fat balance and net fat synthesis as DNL tended to be lower ( P < 0.1) with HCA compared to PLA indicating lower DNL; activity-induced EE was higher with HCA ( P < 0.05) indicating the urge to eliminate the excess of energy ingested. We conclude that an experimental condition resulting in DNL in humans was created and that treatment with HCA during overfeeding with carbohydrates may reduce DNL.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	0031-9384 1873-507X
DOI:	10.1016/j.physbeh.2006.04.005