Effects of (−)-hydroxycitrate on net fat synthesis as de novo lipogenesis

(−)-Hydroxycitrate (HCA) might promote weight maintenance by limiting the capacity for de novo lipogenesis (DNL). It was investigated whether HCA may reduce DNL in humans during a persistent excess of energy intake as carbohydrate. In a double-blind, placebo-controlled, randomized and cross-over des...

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Veröffentlicht in:Physiology & behavior Jg. 88; H. 4; S. 371 - 381
Hauptverfasser: Kovacs, Eva M.R., Westerterp-Plantenga, Margriet S.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Cambridge Elsevier Inc 30.07.2006
New York, NY Elsevier
Schlagworte:
Adult
Affect - drug effects
Anthropometry
Attitude
Biological and medical sciences
Body Composition - drug effects
Body Weight
Calorimetry, Indirect
Citrates - pharmacology
Cross-Over Studies
Dietary Carbohydrates - pharmacology
Double-Blind Method
Energy metabolism
Energy Metabolism - drug effects
Exercise - physiology
Fat synthesis
Fundamental and applied biological sciences. Psychology
Garcinia cambogia
Glycogen - metabolism
Humans
Intermediate and energetic metabolism
Lipid Metabolism - drug effects
Lipids - biosynthesis
Male
Metabolisms and neurohumoral controls
Overfeeding
Oxidation-Reduction
Respiratory Mechanics - physiology
Substrate oxidation
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Energy metabolism
Fat synthesis
Garcinia cambogia
Substrate oxidation
Overfeeding
Human
Placebo
Double blind study
Fat
Oxidation
Lipogenesis
ISSN:0031-9384, 1873-507X
Online-Zugang:Volltext
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Zusammenfassung:(−)-Hydroxycitrate (HCA) might promote weight maintenance by limiting the capacity for de novo lipogenesis (DNL). It was investigated whether HCA may reduce DNL in humans during a persistent excess of energy intake as carbohydrate. In a double-blind, placebo-controlled, randomized and cross-over design, 10 sedentary lean male subjects (mean ± S.D., age: 24 ± 5 years, BMI: 21.8 ± 2.1 kg/m 2) performed a glycogen depletion exercise test followed by a 3-day high-fat diet (F/CHO/P, 60/25/15% energy; 100% of energy expenditure (EE)) and a 7-day high-CHO diet (F/CHO/P, < 5/> 85/10% energy; 130–175% of EE; overfeeding). During overfeeding, they ingested 3 × 500 mg/day HCA or placebo (PLA). Each intervention ended with a 60-h stay in the respiration chamber (days 9 and 10). Body weight increased during overfeeding (mean ± S.E., HCA: 2.9 ± 0.2 kg, PLA: 2.8 ± 0.2 kg). Respiratory quotient (RQ) was > 1.00 in all subjects indicating that DNL was present. On day 9, 24-h EE was lower with HCA compared to PLA ( P < 0.05). On day 10, resting metabolic rate and RQ during night were lower ( P < 0.01 and P < 0.05, respectively). Non-protein RQ, fat balance and net fat synthesis as DNL tended to be lower ( P < 0.1) with HCA compared to PLA indicating lower DNL; activity-induced EE was higher with HCA ( P < 0.05) indicating the urge to eliminate the excess of energy ingested. We conclude that an experimental condition resulting in DNL in humans was created and that treatment with HCA during overfeeding with carbohydrates may reduce DNL.
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ISSN:0031-9384
1873-507X
DOI:10.1016/j.physbeh.2006.04.005