Is autonomic nervous system involved in restless legs syndrome during wakefulness?

•Tendency to ward hypertension in restless leg sydrome (RLS) patients.•Reduced amplitude of sympatho-vagal responses during orthostatic stress.•Involvement of autonomic nervous system in RLS patients during wakefulness. To investigate cardiovascular autonomic function in patients with restless leg s...

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Veröffentlicht in:Sleep medicine Jg. 15; H. 11; S. 1392 - 1397
Hauptverfasser: Izzi, Francesca, Placidi, Fabio, Romigi, Andrea, Lauretti, Benedetta, Marfia, Girolama A., Mercuri, Nicola B., Marciani, Maria G., Rocchi, Camilla
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 01.11.2014
Schlagworte:
Autonomic nervous system
Autonomic Nervous System - physiopathology
Cardiovascular reflexes
Case-Control Studies
Female
Hand Strength - physiology
Heart Rate - physiology
Heart rate variability
Humans
Male
Middle Aged
Neurology
Periodic limb movements
Restless legs syndrome
Restless Legs Syndrome - physiopathology
Sleep
Sleep Medicine
Tilt-Table Test
Valsalva Maneuver
Wakefulness - physiology
Restless legs syndrome
Periodic limb movements
Sleep
Autonomic nervous system
Heart rate variability
Cardiovascular reflexes
ISSN:1389-9457, 1878-5506, 1878-5506
Online-Zugang:Volltext
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Zusammenfassung:•Tendency to ward hypertension in restless leg sydrome (RLS) patients.•Reduced amplitude of sympatho-vagal responses during orthostatic stress.•Involvement of autonomic nervous system in RLS patients during wakefulness. To investigate cardiovascular autonomic function in patients with restless leg syndrome (RLS) by means of cardiovascular reflexes and heart rate variability (HRV) during wakefulness. Twelve RLS patients and 14 controls underwent cardiovascular function tests including head-up tilt test (HUTT), Valsalva maneuver, deep breathing, hand grip, and cold face. HRV analysis was performed in the frequency domain using both autoregressive (AR) and fast Fourier transform algorithms in rest supine condition and during HUTT. There was a significant increase in systolic blood pressure values in supine rest condition and a trend toward a lower Valsalva ratio in RLS patients with respect to controls. The significant and physiological changes of HRV at HUTT detected in healthy subjects were not found in RLS patients. RLS patients exhibit a tendency toward hypertension, reduced amplitude of both sympathetic and parasympathetic responses at HUTT, as well as blunted parasympathetic drive to blood pressure changes. These findings, if confirmed by more controlled studies, might support the hypothesis of autonomic nervous system involvement during wakefulness and consequently an enhanced cardiovascular risk in RLS.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1389-9457
1878-5506
1878-5506
DOI:10.1016/j.sleep.2014.06.022