Non-coding RNA networks in cancer

Key Points Non-coding RNAs (ncRNAs) participate in complex networks of interactions with other nucleic acids and proteins that often have wide-reaching effects on cell biology. The mechanisms by which ncRNAs work and/or function are routinely dysregulated in various cancers. Dysregulation of ncRNA i...

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Published in:	Nature reviews. Cancer Vol. 18; no. 1; pp. 5 - 18
Main Authors:	Anastasiadou, Eleni, Jacob, Leni S., Slack, Frank J.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.01.2018 Nature Publishing Group
Subjects:	631/208/200 631/337/1645 631/337/384 631/67/395 631/80/86 Animals Biomedicine Cancer Cancer Research Carcinogenesis Chromatin remodeling Gene expression Genetic aspects Health aspects Humans Innovations Molecular targeted therapy Neoplasms - genetics Non-coding RNA Post-transcription review-article RNA RNA Processing, Post-Transcriptional - genetics RNA, Untranslated - genetics Signal transduction Signal Transduction - genetics Therapeutic applications Transcription, Genetic - genetics Transduction Tumors
ISSN:	1474-175X, 1474-1768, 1474-1768
Online Access:	Get full text
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Abstract	Key Points Non-coding RNAs (ncRNAs) participate in complex networks of interactions with other nucleic acids and proteins that often have wide-reaching effects on cell biology. The mechanisms by which ncRNAs work and/or function are routinely dysregulated in various cancers. Dysregulation of ncRNA interactions within cancer molecular pathways contributes to cancer and reveals important new targets for intervention. In cancer, disruptions in ncRNA networks often do not involve just mutations that cause a gross gain-of-function or loss-of-function of a given ncRNA but can also involve mutations that change the sequence and downstream targets of that ncRNA. Non-coding RNAs (ncRNAs) are functional molecules that regulate physiological programmes in developmental and disease contexts. This Review article discusses the complex networks of interactions that ncRNAs engage in and how these confer oncogenic or tumour-suppressive effects in cancer. Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the past decade has altered our perception of ncRNAs from 'junk' transcriptional products to functional regulatory molecules that mediate cellular processes including chromatin remodelling, transcription, post-transcriptional modifications and signal transduction. The networks in which ncRNAs engage can influence numerous molecular targets to drive specific cell biological responses and fates. Consequently, ncRNAs act as key regulators of physiological programmes in developmental and disease contexts. Particularly relevant in cancer, ncRNAs have been identified as oncogenic drivers and tumour suppressors in every major cancer type. Thus, a deeper understanding of the complex networks of interactions that ncRNAs coordinate would provide a unique opportunity to design better therapeutic interventions.
AbstractList	Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the past decade has altered our perception of ncRNAs from ‘junk’ transcriptional products to functional regulatory molecules that mediate cellular processes including chromatin remodelling, transcription, post-transcriptional modifications and signal transduction. The networks in which ncRNAs engage can influence numerous molecular targets to drive specific cell biological responses and fates. Consequently, ncRNAs act as key regulators of physiological programmes in developmental and disease contexts. Particularly relevant in cancer, ncRNAs have been identified as oncogenic drivers and tumour suppressors in every major cancer type. Thus, a deeper understanding of the complex networks of interactions that ncRNAs coordinate would provide a unique opportunity to design better therapeutic interventions. Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the past decade has altered our perception of ncRNAs from 'junk' transcriptional products to functional regulatory molecules that mediate cellular processes including chromatin remodelling, transcription, post-transcriptional modifications and signal transduction. The networks in which ncRNAs engage can influence numerous molecular targets to drive specific cell biological responses and fates. Consequently, ncRNAs act as key regulators of physiological programmes in developmental and disease contexts. Particularly relevant in cancer, ncRNAs have been identified as oncogenic drivers and tumour suppressors in every major cancer type. Thus, a deeper understanding of the complex networks of interactions that ncRNAs coordinate would provide a unique opportunity to design better therapeutic interventions.Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the past decade has altered our perception of ncRNAs from 'junk' transcriptional products to functional regulatory molecules that mediate cellular processes including chromatin remodelling, transcription, post-transcriptional modifications and signal transduction. The networks in which ncRNAs engage can influence numerous molecular targets to drive specific cell biological responses and fates. Consequently, ncRNAs act as key regulators of physiological programmes in developmental and disease contexts. Particularly relevant in cancer, ncRNAs have been identified as oncogenic drivers and tumour suppressors in every major cancer type. Thus, a deeper understanding of the complex networks of interactions that ncRNAs coordinate would provide a unique opportunity to design better therapeutic interventions. Key Points Non-coding RNAs (ncRNAs) participate in complex networks of interactions with other nucleic acids and proteins that often have wide-reaching effects on cell biology. The mechanisms by which ncRNAs work and/or function are routinely dysregulated in various cancers. Dysregulation of ncRNA interactions within cancer molecular pathways contributes to cancer and reveals important new targets for intervention. In cancer, disruptions in ncRNA networks often do not involve just mutations that cause a gross gain-of-function or loss-of-function of a given ncRNA but can also involve mutations that change the sequence and downstream targets of that ncRNA. Non-coding RNAs (ncRNAs) are functional molecules that regulate physiological programmes in developmental and disease contexts. This Review article discusses the complex networks of interactions that ncRNAs engage in and how these confer oncogenic or tumour-suppressive effects in cancer. Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the past decade has altered our perception of ncRNAs from 'junk' transcriptional products to functional regulatory molecules that mediate cellular processes including chromatin remodelling, transcription, post-transcriptional modifications and signal transduction. The networks in which ncRNAs engage can influence numerous molecular targets to drive specific cell biological responses and fates. Consequently, ncRNAs act as key regulators of physiological programmes in developmental and disease contexts. Particularly relevant in cancer, ncRNAs have been identified as oncogenic drivers and tumour suppressors in every major cancer type. Thus, a deeper understanding of the complex networks of interactions that ncRNAs coordinate would provide a unique opportunity to design better therapeutic interventions.
Audience	Academic
Author	Slack, Frank J. Jacob, Leni S. Anastasiadou, Eleni
Author_xml	– sequence: 1 givenname: Eleni surname: Anastasiadou fullname: Anastasiadou, Eleni organization: Department of Pathology, Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School – sequence: 2 givenname: Leni S. surname: Jacob fullname: Jacob, Leni S. organization: Department of Pathology, Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School – sequence: 3 givenname: Frank J. surname: Slack fullname: Slack, Frank J. email: fslack@bidmc.harvard.edu organization: Department of Pathology, Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29170536$$D View this record in MEDLINE/PubMed
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 These authors contributed equally to this work. E.A. and L.S.J. researched the data for the article. E.A., L.S.J. and F.J.S. provided substantial contributions to discussions of its content, wrote the article and undertook review and/or editing of the manuscript before submission. Author contributions
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Snippet	Key Points Non-coding RNAs (ncRNAs) participate in complex networks of interactions with other nucleic acids and proteins that often have wide-reaching effects... Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the past decade has altered our perception of ncRNAs from 'junk'... Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the past decade has altered our perception of ncRNAs from ‘junk’...
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SubjectTerms	631/208/200 631/337/1645 631/337/384 631/67/395 631/80/86 Animals Biomedicine Cancer Cancer Research Carcinogenesis Chromatin remodeling Gene expression Genetic aspects Health aspects Humans Innovations Molecular targeted therapy Neoplasms - genetics Non-coding RNA Post-transcription review-article RNA RNA Processing, Post-Transcriptional - genetics RNA, Untranslated - genetics Signal transduction Signal Transduction - genetics Therapeutic applications Transcription, Genetic - genetics Transduction Tumors
Title	Non-coding RNA networks in cancer
URI	https://link.springer.com/article/10.1038/nrc.2017.99 https://www.ncbi.nlm.nih.gov/pubmed/29170536 https://www.proquest.com/docview/1978779043 https://www.proquest.com/docview/1968442826 https://pubmed.ncbi.nlm.nih.gov/PMC6337726
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