von Willebrand factor and cancer: A renewed interest

Von Willebrand factor (VWF), the largest human plasma protein, is an adhesive multimeric glycoprotein that mediates platelet adhesion to both the subendothelial matrix and endothelial surfaces and acts as a carrier for coagulation factor VIII in the circulation. Besides its essential role in hemosta...

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Vydáno v:Thrombosis research Ročník 131; číslo 4; s. 290 - 292
Hlavní autoři: Franchini, Massimo, Frattini, Francesco, Crestani, Silvia, Bonfanti, Carlo, Lippi, Giuseppe
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Ltd 01.04.2013
Témata:
angiogenesis
Animals
Blood Coagulation Tests - methods
cancer
Hematology, Oncology, and Palliative Medicine
Humans
metastasis
Neoplasms - blood
von Willebrand disease
von Willebrand factor
von Willebrand Factor - metabolism
metastasis
VEGFR-2
von Willebrand factor
angiogenesis
Ang-2
von Willebrand disease
IGFBP7
cancer
CTGF
angiopoietin-2
vascular endothelial growth factor receptor 2
connective tissue growth factors
insulin-like growth factor binding protein-7
ISSN:0049-3848, 1879-2472, 1879-2472
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Popis
Shrnutí:Von Willebrand factor (VWF), the largest human plasma protein, is an adhesive multimeric glycoprotein that mediates platelet adhesion to both the subendothelial matrix and endothelial surfaces and acts as a carrier for coagulation factor VIII in the circulation. Besides its essential role in hemostasis, there is growing evidence from the literature that VWF has an additional antitumor effect, mainly by exerting negative modulation on angiogenesis and apoptosis. Current knowledge on the link between VWF and cancer is summarized in this review, based on an analysis of the most important experimental and clinical studies.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:0049-3848
1879-2472
1879-2472
DOI:10.1016/j.thromres.2013.01.015