von Willebrand factor and cancer: A renewed interest

Von Willebrand factor (VWF), the largest human plasma protein, is an adhesive multimeric glycoprotein that mediates platelet adhesion to both the subendothelial matrix and endothelial surfaces and acts as a carrier for coagulation factor VIII in the circulation. Besides its essential role in hemosta...

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Veröffentlicht in:Thrombosis research Jg. 131; H. 4; S. 290 - 292
Hauptverfasser: Franchini, Massimo, Frattini, Francesco, Crestani, Silvia, Bonfanti, Carlo, Lippi, Giuseppe
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Elsevier Ltd 01.04.2013
Schlagworte:
angiogenesis
Animals
Blood Coagulation Tests - methods
cancer
Hematology, Oncology, and Palliative Medicine
Humans
metastasis
Neoplasms - blood
von Willebrand disease
von Willebrand factor
von Willebrand Factor - metabolism
metastasis
VEGFR-2
von Willebrand factor
angiogenesis
Ang-2
von Willebrand disease
IGFBP7
cancer
CTGF
angiopoietin-2
vascular endothelial growth factor receptor 2
connective tissue growth factors
insulin-like growth factor binding protein-7
ISSN:0049-3848, 1879-2472, 1879-2472
Online-Zugang:Volltext
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Zusammenfassung:Von Willebrand factor (VWF), the largest human plasma protein, is an adhesive multimeric glycoprotein that mediates platelet adhesion to both the subendothelial matrix and endothelial surfaces and acts as a carrier for coagulation factor VIII in the circulation. Besides its essential role in hemostasis, there is growing evidence from the literature that VWF has an additional antitumor effect, mainly by exerting negative modulation on angiogenesis and apoptosis. Current knowledge on the link between VWF and cancer is summarized in this review, based on an analysis of the most important experimental and clinical studies.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0049-3848
1879-2472
1879-2472
DOI:10.1016/j.thromres.2013.01.015