Vascular endothelial growth factor and endocan expression in adrenal cortical tumors and their relationship with histopathological prognostic parameters

The aim of this study was to determine the tissue expressions of vascular endothelial growth factor (VEGF) and endocan in adrenal cortical tumors and the factors associated with them. The study included 6 subjects with adrenocortical adenoma (ACA), 7 subjects with adrenocortical carcinoma (ACC), and...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Endocrine Journal Ročník 71; číslo 8; s. 789 - 797
Hlavní autori: Karaköse, Melia, Kocabaş, Muhammet, Can, Mustafa, Karakurt, Feridun, Kulaksızoğlu, Mustafa, Esen, Hacı Hasan
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Japan The Japan Endocrine Society 01.01.2024
Japan Science and Technology Agency
Predmet:
Adrenal cortex
Adrenal Cortex - metabolism
Adrenal Cortex - pathology
Adrenal Cortex Neoplasms - genetics
Adrenal Cortex Neoplasms - metabolism
Adrenal Cortex Neoplasms - pathology
Adrenal cortical tumor
Adrenocortical Adenoma - genetics
Adrenocortical Adenoma - metabolism
Adrenocortical Adenoma - pathology
Adrenocortical Carcinoma - metabolism
Adrenocortical Carcinoma - pathology
Adult
Aged
Endocan
Female
Humans
Male
Middle Aged
Neoplasm Proteins - biosynthesis
Neoplasm Proteins - metabolism
Prognosis
Proteoglycans - genetics
Proteoglycans - metabolism
Tumors
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - metabolism
Young Adult
Endocan
Vascular endothelial growth factor
Adrenal cortical tumor
ISSN:0918-8959, 1348-4540, 1348-4540
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:The aim of this study was to determine the tissue expressions of vascular endothelial growth factor (VEGF) and endocan in adrenal cortical tumors and the factors associated with them. The study included 6 subjects with adrenocortical adenoma (ACA), 7 subjects with adrenocortical carcinoma (ACC), and 13 control subjects with a normal adrenal cortex. The status of VEGF and endocan expression was determined by the proportions of cells staining on a scale ranging from negative (not staining at all) to strongly positive. VEGF expression was detected in 1 (16.7%) of 6 subjects in the ACA group and in 6 (85.7%) of 7 subjects in the ACC group. VEGF expression was not detected in any of the subjects in the control group. Endocan expression was detected in 6 (100%) of 6 subjects in the ACA group and in 7 (100%) of 7 subjects in the ACC group, while it was detected in only 4 (30.7%) of 13 subjects in the control group. VEGF was expressed with a high frequency in subjects with ACC and with a low frequency in subjects with ACA, but it was not expressed in subjects with normal adrenal cortex tissue. Although endocan was expressed with a higher frequency in subjects with ACC and ACA, it was also expressed in subjects with normal adrenal cortex tissue. The percentage of cells expressed endocan in subjects with ACC was also significantly higher than in subjects with both ACA and normal adrenal cortex.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0918-8959
1348-4540
1348-4540
DOI:10.1507/endocrj.EJ24-0032