Levodopa Dose Equivalency in Parkinson's Disease: Updated Systematic Review and Proposals
Background To compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed. These are reported in relation to levodopa as the benchmark drug in PD pharmacotherapy as ‘levodopa equivalent dose’ (LED). Currently, t...
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| Published in: | Movement disorders Vol. 38; no. 7; pp. 1236 - 1252 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Hoboken, USA
John Wiley & Sons, Inc
01.07.2023
Wiley Subscription Services, Inc |
| Subjects: | |
| ISSN: | 0885-3185, 1531-8257, 1531-8257 |
| Online Access: | Get full text |
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| Abstract | Background
To compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed. These are reported in relation to levodopa as the benchmark drug in PD pharmacotherapy as ‘levodopa equivalent dose’ (LED). Currently, the LED conversion formulae proposed in 2010 by Tomlinson et al. based on a systematic review are predominantly used. However, new drugs with established and novel mechanisms of action and novel formulations of longstanding drugs have been developed since 2010. Therefore, consensus proposals for updated LED conversion formulae are needed.
Objectives
To update LED conversion formulae based on a systematic review.
Methods
The MEDLINE, CENTRAL, and Embase databases were searched from January 2010 to July 2021. Additionally, in a standardized process according to the GRADE grid method, consensus proposals were issued for drugs with scarce data on levodopa dose equivalency.
Results
The systematic database search yielded 3076 articles of which 682 were eligible for inclusion in the systematic review. Based on these data and the standardized consensus process, we present proposals for LED conversion formulae for a wide range of drugs that are currently available for the pharmacotherapy of PD or are expected to be introduced soon.
Conclusions
The LED conversion formulae issued in this Position Paper will serve as a research tool to compare the equivalence of antiparkinsonian medication across PD study cohorts and facilitate research on the clinical efficacy of pharmacological and surgical treatments as well as other non‐pharmacological interventions in PD. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. |
|---|---|
| AbstractList | Background
To compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed. These are reported in relation to levodopa as the benchmark drug in PD pharmacotherapy as ‘levodopa equivalent dose’ (LED). Currently, the LED conversion formulae proposed in 2010 by Tomlinson et al. based on a systematic review are predominantly used. However, new drugs with established and novel mechanisms of action and novel formulations of longstanding drugs have been developed since 2010. Therefore, consensus proposals for updated LED conversion formulae are needed.
Objectives
To update LED conversion formulae based on a systematic review.
Methods
The MEDLINE, CENTRAL, and Embase databases were searched from January 2010 to July 2021. Additionally, in a standardized process according to the GRADE grid method, consensus proposals were issued for drugs with scarce data on levodopa dose equivalency.
Results
The systematic database search yielded 3076 articles of which 682 were eligible for inclusion in the systematic review. Based on these data and the standardized consensus process, we present proposals for LED conversion formulae for a wide range of drugs that are currently available for the pharmacotherapy of PD or are expected to be introduced soon.
Conclusions
The LED conversion formulae issued in this Position Paper will serve as a research tool to compare the equivalence of antiparkinsonian medication across PD study cohorts and facilitate research on the clinical efficacy of pharmacological and surgical treatments as well as other non‐pharmacological interventions in PD. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. BackgroundTo compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed. These are reported in relation to levodopa as the benchmark drug in PD pharmacotherapy as ‘levodopa equivalent dose’ (LED). Currently, the LED conversion formulae proposed in 2010 by Tomlinson et al. based on a systematic review are predominantly used. However, new drugs with established and novel mechanisms of action and novel formulations of longstanding drugs have been developed since 2010. Therefore, consensus proposals for updated LED conversion formulae are needed.ObjectivesTo update LED conversion formulae based on a systematic review.MethodsThe MEDLINE, CENTRAL, and Embase databases were searched from January 2010 to July 2021. Additionally, in a standardized process according to the GRADE grid method, consensus proposals were issued for drugs with scarce data on levodopa dose equivalency.ResultsThe systematic database search yielded 3076 articles of which 682 were eligible for inclusion in the systematic review. Based on these data and the standardized consensus process, we present proposals for LED conversion formulae for a wide range of drugs that are currently available for the pharmacotherapy of PD or are expected to be introduced soon.ConclusionsThe LED conversion formulae issued in this Position Paper will serve as a research tool to compare the equivalence of antiparkinsonian medication across PD study cohorts and facilitate research on the clinical efficacy of pharmacological and surgical treatments as well as other non‐pharmacological interventions in PD. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. To compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed. These are reported in relation to levodopa as the benchmark drug in PD pharmacotherapy as 'levodopa equivalent dose' (LED). Currently, the LED conversion formulae proposed in 2010 by Tomlinson et al. based on a systematic review are predominantly used. However, new drugs with established and novel mechanisms of action and novel formulations of longstanding drugs have been developed since 2010. Therefore, consensus proposals for updated LED conversion formulae are needed.BACKGROUNDTo compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed. These are reported in relation to levodopa as the benchmark drug in PD pharmacotherapy as 'levodopa equivalent dose' (LED). Currently, the LED conversion formulae proposed in 2010 by Tomlinson et al. based on a systematic review are predominantly used. However, new drugs with established and novel mechanisms of action and novel formulations of longstanding drugs have been developed since 2010. Therefore, consensus proposals for updated LED conversion formulae are needed.To update LED conversion formulae based on a systematic review.OBJECTIVESTo update LED conversion formulae based on a systematic review.The MEDLINE, CENTRAL, and Embase databases were searched from January 2010 to July 2021. Additionally, in a standardized process according to the GRADE grid method, consensus proposals were issued for drugs with scarce data on levodopa dose equivalency.METHODSThe MEDLINE, CENTRAL, and Embase databases were searched from January 2010 to July 2021. Additionally, in a standardized process according to the GRADE grid method, consensus proposals were issued for drugs with scarce data on levodopa dose equivalency.The systematic database search yielded 3076 articles of which 682 were eligible for inclusion in the systematic review. Based on these data and the standardized consensus process, we present proposals for LED conversion formulae for a wide range of drugs that are currently available for the pharmacotherapy of PD or are expected to be introduced soon.RESULTSThe systematic database search yielded 3076 articles of which 682 were eligible for inclusion in the systematic review. Based on these data and the standardized consensus process, we present proposals for LED conversion formulae for a wide range of drugs that are currently available for the pharmacotherapy of PD or are expected to be introduced soon.The LED conversion formulae issued in this Position Paper will serve as a research tool to compare the equivalence of antiparkinsonian medication across PD study cohorts and facilitate research on the clinical efficacy of pharmacological and surgical treatments as well as other non-pharmacological interventions in PD. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.CONCLUSIONSThe LED conversion formulae issued in this Position Paper will serve as a research tool to compare the equivalence of antiparkinsonian medication across PD study cohorts and facilitate research on the clinical efficacy of pharmacological and surgical treatments as well as other non-pharmacological interventions in PD. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. To compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed. These are reported in relation to levodopa as the benchmark drug in PD pharmacotherapy as 'levodopa equivalent dose' (LED). Currently, the LED conversion formulae proposed in 2010 by Tomlinson et al. based on a systematic review are predominantly used. However, new drugs with established and novel mechanisms of action and novel formulations of longstanding drugs have been developed since 2010. Therefore, consensus proposals for updated LED conversion formulae are needed. To update LED conversion formulae based on a systematic review. The MEDLINE, CENTRAL, and Embase databases were searched from January 2010 to July 2021. Additionally, in a standardized process according to the GRADE grid method, consensus proposals were issued for drugs with scarce data on levodopa dose equivalency. The systematic database search yielded 3076 articles of which 682 were eligible for inclusion in the systematic review. Based on these data and the standardized consensus process, we present proposals for LED conversion formulae for a wide range of drugs that are currently available for the pharmacotherapy of PD or are expected to be introduced soon. The LED conversion formulae issued in this Position Paper will serve as a research tool to compare the equivalence of antiparkinsonian medication across PD study cohorts and facilitate research on the clinical efficacy of pharmacological and surgical treatments as well as other non-pharmacological interventions in PD. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. Background: To compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed. These are reported in relation to levodopa as the benchmark drug in PD pharmacotherapy as ‘levodopa equivalent dose’ (LED). Currently, the LED conversion formulae proposed in 2010 by Tomlinson et al. based on a systematic review are predominantly used. However, new drugs with established and novel mechanisms of action and novel formulations of longstanding drugs have been developed since 2010. Therefore, consensus proposals for updated LED conversion formulae are needed. Objectives: To update LED conversion formulae based on a systematic review. Methods: The MEDLINE, CENTRAL, and Embase databases were searched from January 2010 to July 2021. Additionally, in a standardized process according to the GRADE grid method, consensus proposals were issued for drugs with scarce data on levodopa dose equivalency. Results: The systematic database search yielded 3076 articles of which 682 were eligible for inclusion in the systematic review. Based on these data and the standardized consensus process, we present proposals for LED conversion formulae for a wide range of drugs that are currently available for the pharmacotherapy of PD or are expected to be introduced soon. Conclusions: The LED conversion formulae issued in this Position Paper will serve as a research tool to compare the equivalence of antiparkinsonian medication across PD study cohorts and facilitate research on the clinical efficacy of pharmacological and surgical treatments as well as other non-pharmacological interventions in PD. |
| Author | Cardoso, Francisco Schade, Sebastian Stocchi, Fabrizio Dafsari, Haidar S. Rodríguez‐Violante, Mayela Deuschl, Guenther Petry‐Schmelzer, Jan Niklas Metta, Vinod Katzenschlager, Regina Fung, Victor S.C. Fasano, Alfonso Kukkle, Prashanth Lingappa Jost, Stefanie T. Bhidayasiri, Roongroj Falup‐Pecurariu, Cristian Espay, Alberto J. Odin, Per Timmermann, Lars Jenner, Peter Martinez‐Martin, Pablo Antonini, Angelo Tan, Eng‐King Borgohain, Rupam Ray Chaudhuri, K. Hattori, Nobutaka Weintraub, Daniel Kaldenbach, Marie‐Ann Trenkwalder, Claudia |
| Author_xml | – sequence: 1 givenname: Stefanie T. orcidid: 0000-0003-0477-2289 surname: Jost fullname: Jost, Stefanie T. organization: Faculty of Medicine and University Hospital Cologne, University of Cologne – sequence: 2 givenname: Marie‐Ann surname: Kaldenbach fullname: Kaldenbach, Marie‐Ann organization: Faculty of Medicine and University Hospital Cologne, University of Cologne – sequence: 3 givenname: Angelo orcidid: 0000-0003-1040-2807 surname: Antonini fullname: Antonini, Angelo organization: University of Padua – sequence: 4 givenname: Pablo orcidid: 0000-0003-0837-5280 surname: Martinez‐Martin fullname: Martinez‐Martin, Pablo organization: Carlos III Institute of Health – sequence: 5 givenname: Lars surname: Timmermann fullname: Timmermann, Lars organization: University Hospital Giessen and Marburg – sequence: 6 givenname: Per surname: Odin fullname: Odin, Per organization: Skåne University Hospital – sequence: 7 givenname: Regina surname: Katzenschlager fullname: Katzenschlager, Regina organization: Karl Landsteiner Institute for Neuroimmunological and Neurodegenerative Disorders at Klinik Donaustadt – sequence: 8 givenname: Rupam surname: Borgohain fullname: Borgohain, Rupam organization: Nizam's Institute of Medical Sciences – sequence: 9 givenname: Alfonso orcidid: 0000-0001-5346-0180 surname: Fasano fullname: Fasano, Alfonso organization: Moriggia‐Pelascini Hospital–Gravedona ed Uniti – sequence: 10 givenname: Fabrizio surname: Stocchi fullname: Stocchi, Fabrizio organization: University and Institute for Research and Medical Care IRCCS San Raffaele – sequence: 11 givenname: Nobutaka surname: Hattori fullname: Hattori, Nobutaka organization: Juntendo University Graduate School of Medicine – sequence: 12 givenname: Prashanth Lingappa orcidid: 0000-0002-4610-947X surname: Kukkle fullname: Kukkle, Prashanth Lingappa organization: Parkinson's Disease and Movement Disorders Clinic – sequence: 13 givenname: Mayela orcidid: 0000-0002-6041-9941 surname: Rodríguez‐Violante fullname: Rodríguez‐Violante, Mayela organization: National Institute of Neurology and Neurosurgery – sequence: 14 givenname: Cristian surname: Falup‐Pecurariu fullname: Falup‐Pecurariu, Cristian organization: County Emergency Clinic Hospital – sequence: 15 givenname: Sebastian orcidid: 0000-0002-6316-6804 surname: Schade fullname: Schade, Sebastian organization: University Medical Center Göttingen – sequence: 16 givenname: Jan Niklas orcidid: 0000-0003-0749-3840 surname: Petry‐Schmelzer fullname: Petry‐Schmelzer, Jan Niklas organization: Faculty of Medicine and University Hospital Cologne, University of Cologne – sequence: 17 givenname: Vinod surname: Metta fullname: Metta, Vinod organization: King's College London – sequence: 18 givenname: Daniel orcidid: 0000-0003-0633-7168 surname: Weintraub fullname: Weintraub, Daniel organization: Corporal Michael J. Crescenz Veterans Affairs Medical Center – sequence: 19 givenname: Guenther orcidid: 0000-0002-4176-9196 surname: Deuschl fullname: Deuschl, Guenther organization: University Hospital Schleswig‐Holstein (UKSH), Christian‐Albrechts‐University Kiel – sequence: 20 givenname: Alberto J. orcidid: 0000-0002-3389-136X surname: Espay fullname: Espay, Alberto J. organization: University of Cincinnati – sequence: 21 givenname: Eng‐King surname: Tan fullname: Tan, Eng‐King organization: Duke–NUS Medical School – sequence: 22 givenname: Roongroj orcidid: 0000-0002-6901-2064 surname: Bhidayasiri fullname: Bhidayasiri, Roongroj organization: The Royal Society of Thailand – sequence: 23 givenname: Victor S.C. orcidid: 0000-0003-3085-2282 surname: Fung fullname: Fung, Victor S.C. organization: Westmead Hospital – sequence: 24 givenname: Francisco orcidid: 0000-0003-0808-0116 surname: Cardoso fullname: Cardoso, Francisco organization: Universidade Federal de Minas Gerais – sequence: 25 givenname: Claudia surname: Trenkwalder fullname: Trenkwalder, Claudia organization: University Medical Center Göttingen – sequence: 26 givenname: Peter surname: Jenner fullname: Jenner, Peter organization: King's College London – sequence: 27 givenname: K. surname: Ray Chaudhuri fullname: Ray Chaudhuri, K. organization: South London and Maudsley NHS Foundation Trust and King's College London – sequence: 28 givenname: Haidar S. surname: Dafsari fullname: Dafsari, Haidar S. email: haidar.dafsari@uk-koeln.de organization: Faculty of Medicine and University Hospital Cologne, University of Cologne |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37147135$$D View this record in MEDLINE/PubMed |
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| Copyright | 2023 The Authors. published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. 2023. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| CorporateAuthor | the International Parkinson and Movement Disorders Society Non‐Motor Parkinson Disease Study Group International Parkinson and Movement Disorders Society Non-Motor Parkinson Disease Study Group Lunds universitets profilområden Institutionen för kliniska vetenskaper, Lund LU Profile Area: Proactive Ageing MultiPark: Multidisciplinary research focused on Parkinson's disease Lunds universitet Profile areas and other strong research environments Lund University Restorative Parkinson Unit Lund University Profile areas Department of Clinical Sciences, Lund Neurology, Lund Strategiska forskningsområden (SFO) Faculty of Medicine Strategic research areas (SRA) Section IV Medicinska fakulteten Sektion IV LU profilområde: Proaktivt åldrande Profilområden och andra starka forskningsmiljöer Neurologi, Lund |
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| Notes | registration number Stefanie T. Jost and Marie‐Ann Kaldenbach contributed equally. None. PROSPERO Financial Disclosure/Conflict of Interest concerning the research related to the manuscript CRD42021239664. K. Ray Chaudhuri and Haidar S. Dafsari contributed equally. Funding sources of the study Correction added on 19 May 2023, after first online publication: The affiliation of K. Ray Chaudhuri has changed in this version. ObjectType-Article-1 ObjectType-Evidence Based Healthcare-3 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 |
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To compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed.... To compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed. These are... BackgroundTo compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed.... Background: To compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed.... |
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| SubjectTerms | Basic Medicine Clinical trials Drug dosages Drug therapy Farmaceutiska vetenskaper LEDD Levodopa levodopa equivalent daily dose levodopa equivalent dose Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Movement disorders Neurodegenerative diseases Non-pharmacological intervention Parkinson's disease Pharmaceutical Sciences Reviews Systematic review |
| Title | Levodopa Dose Equivalency in Parkinson's Disease: Updated Systematic Review and Proposals |
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