FABP7 is increased in progressive multiple sclerosis and induces a pro-inflammatory phenotype in monocytes through a glycolytic switch

Multiple sclerosis (MS) involves dysregulation of innate immune cells including monocytes, especially in progressive MS. Fatty acid binding proteins (FABP) are essential for fatty acid transport and metabolism in multiple cell types. FABP7, a brain-FABP, maintains metabolic function in astrocytes an...

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Veröffentlicht in:	Nature communications Jg. 16; H. 1; S. 6049 - 18
Hauptverfasser:	Patel, Rohit, King, Devin, LaBarre, Brenna, Lokhande, Hrishikesh, Caefer, Danielle, Varghese, Johnna F., Warner, Keturah, Bouffard, Marc A., Saxena, Shrishti, Zhirova, Alena, Bakshi, Rohit, Chitnis, Tanuja
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.07.2025 Nature Publishing Group Nature Portfolio
Schlagworte:	13 13/1 13/31 14/1 14/19 14/34 38/109 38/77 38/88 38/89 38/90 38/91 631/250/2504/342 631/250/371 631/250/38 692/53/2422 Adult Age Amyotrophic lateral sclerosis Astrocytes Astrocytes - metabolism Biomarkers Biomarkers - blood Biomarkers - cerebrospinal fluid Brain Brain - metabolism Brain - pathology CD16 antigen CD80 antigen Cerebrospinal fluid Chemotaxis Cytokines Demography Disease Fatty acid-binding protein Fatty Acid-Binding Protein 7 - blood Fatty Acid-Binding Protein 7 - genetics Fatty Acid-Binding Protein 7 - metabolism Fatty Acid-Binding Proteins - blood Fatty Acid-Binding Proteins - metabolism Fatty acids Female Gene expression Genotype & phenotype Glucose metabolism Glycolysis Humanities and Social Sciences Humans Immune system Inflammation Inflammation - metabolism Interleukin-1beta - metabolism Lesions Lipids Male Middle Aged Monocytes Monocytes - immunology Monocytes - metabolism multidisciplinary Multiple sclerosis Multiple Sclerosis - metabolism Multiple Sclerosis, Chronic Progressive - blood Multiple Sclerosis, Chronic Progressive - immunology Multiple Sclerosis, Chronic Progressive - metabolism Multiple Sclerosis, Chronic Progressive - pathology Neural stem cells Neuroimaging Pathogenesis Peripheral blood Phenotype Phenotypes Science Science (multidisciplinary) Stem cells Therapeutic targets Tumor Suppressor Proteins
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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