A point-of-care diagnostic for drug-induced liver injury using surface-enhanced Raman scattering lateral flow immunoassay

Paracetamol overdose (POD) is common, with approximately 100,000 cases attending UK hospitals annually. Timely antidote administration is crucial for patients at risk of developing acute liver failure. A rapid point-of-care (POC) assay is required to identify high-risk patients with fit-for-purpose...

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Bibliographic Details
Published in:	Nature communications Vol. 16; no. 1; pp. 6223 - 13
Main Authors:	Sloan-Dennison, Sian, Scullion, Kathleen M., Clark, Benjamin, Fineran, Paul, Mair, Joanne, Laing, Stacey, Shand, Neil C., Rathmell, Cicely, Creasey, David, Bingemann, Dieter, Faircloth, Jonathan, Zieg, Mark, Varghese, Elizabeth, Weir, Christopher J., Dear, James W., Faulds, Karen, Graham, Duncan
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 06.07.2025 Nature Publishing Group Nature Portfolio
Subjects:	140/133 631/1647/527/1821 631/61/32 692/4020/4021/1607/2749 692/53/2421 82/1 Acetaminophen - adverse effects Analgesics Antibodies Biomarkers Biomarkers - blood Chemical and Drug Induced Liver Injury - blood Chemical and Drug Induced Liver Injury - diagnosis Cytokeratin Emergency medical care Female Gold Humanities and Social Sciences Humans Immunoassay Immunoassay - instrumentation Immunoassay - methods Keratin-18 - blood Lasers Liver Liver failure Male Medical devices multidisciplinary Nanoparticles Overdose Paracetamol Patients Performance evaluation Point-of-Care Systems Point-of-Care Testing Raman spectra Risk Risk groups Science Science (multidisciplinary) Sensitivity Sensitivity and Specificity Spectrum analysis Spectrum Analysis, Raman - instrumentation Spectrum Analysis, Raman - methods Transplants & implants United Kingdom > UK United States > US
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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