A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage

Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, str...

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Veröffentlicht in:Nature communications Jg. 16; H. 1; S. 5782 - 17
Hauptverfasser: Huang, Xingcan, Zhang, Qiang, Yang, Yawen, Chow, Lung, Ma, Jie, Xu, Guoqiang, Guo, Fang, He, Xinxin, Li, Zhiyuan, Zhao, Guangyao, Su, Jingyou, Guo, Guihuan, Wang, Jiachen, Jiao, Yanli, Gao, Zhan, Li, Jiyu, Zhou, Jingkun, Yiu, Chun Ki, Li, Jian, Chen, Yi, Wu, Pengcheng, Yao, Kuanming, Liu, Yiming, Li, Dengfeng, Zhang, Binbin, Chu, Hongwei, Hu, Yue, Huang, Ya, Chen, Zhenlin, Ren, Kangning, Fang, Bo, Yang, Rungong, Li, Heng, Tao, Xiaoming, Ma, Xiaohui, Yu, Xinge
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 01.07.2025
Nature Publishing Group
Nature Portfolio
Schlagworte:
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Adhesion
Adhesives
Adolescent
Adult
Aged
Aged, 80 and over
Animals
Bandages
Biomaterials
Biomedical materials
Biosensors
Clinical trials
Closed loops
Diabetes
Electronics
Female
Glucose
Humanities and Social Sciences
Humans
In vivo methods and tests
Infections
Male
Medical dressings
Mice
Middle Aged
Monitoring
multidisciplinary
Permeability
Real time
Science
Science (multidisciplinary)
Skin
Skin - injuries
Smartphones
Waterproofing
Wireless communications
Wound healing
Wound Healing - physiology
Young Adult
ISSN:2041-1723, 2041-1723
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Beschreibung
Zusammenfassung:Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, stretchable electronic wound bandage (iSAFE) for intelligent wound management. This electronic bandage exhibits superior properties in multiple features and can be conformally adhered to the skin wound. In addition, the iSAFE can accurately assess the wound conditions in-situ and thus adaptively perform localized drug release. The results from both in vitro and in vivo studies on animals prove the validity of wound monitoring, wound healing boosting and intelligent closed-loop wound management. Clinical trials on patients across age 18 to 95 with various types of wounds are performed. These results all indicate the unique and universality of the reported technology for wound monitoring and management. Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-025-61261-8