A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage

Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, str...

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Vydáno v:Nature communications Ročník 16; číslo 1; s. 5782 - 17
Hlavní autoři: Huang, Xingcan, Zhang, Qiang, Yang, Yawen, Chow, Lung, Ma, Jie, Xu, Guoqiang, Guo, Fang, He, Xinxin, Li, Zhiyuan, Zhao, Guangyao, Su, Jingyou, Guo, Guihuan, Wang, Jiachen, Jiao, Yanli, Gao, Zhan, Li, Jiyu, Zhou, Jingkun, Yiu, Chun Ki, Li, Jian, Chen, Yi, Wu, Pengcheng, Yao, Kuanming, Liu, Yiming, Li, Dengfeng, Zhang, Binbin, Chu, Hongwei, Hu, Yue, Huang, Ya, Chen, Zhenlin, Ren, Kangning, Fang, Bo, Yang, Rungong, Li, Heng, Tao, Xiaoming, Ma, Xiaohui, Yu, Xinge
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 01.07.2025
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Nature Portfolio
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ISSN:2041-1723, 2041-1723
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Abstract Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, stretchable electronic wound bandage (iSAFE) for intelligent wound management. This electronic bandage exhibits superior properties in multiple features and can be conformally adhered to the skin wound. In addition, the iSAFE can accurately assess the wound conditions in-situ and thus adaptively perform localized drug release. The results from both in vitro and in vivo studies on animals prove the validity of wound monitoring, wound healing boosting and intelligent closed-loop wound management. Clinical trials on patients across age 18 to 95 with various types of wounds are performed. These results all indicate the unique and universality of the reported technology for wound monitoring and management. Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.
AbstractList Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, stretchable electronic wound bandage (iSAFE) for intelligent wound management. This electronic bandage exhibits superior properties in multiple features and can be conformally adhered to the skin wound. In addition, the iSAFE can accurately assess the wound conditions in-situ and thus adaptively perform localized drug release. The results from both in vitro and in vivo studies on animals prove the validity of wound monitoring, wound healing boosting and intelligent closed-loop wound management. Clinical trials on patients across age 18 to 95 with various types of wounds are performed. These results all indicate the unique and universality of the reported technology for wound monitoring and management. Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.
Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, stretchable electronic wound bandage (iSAFE) for intelligent wound management. This electronic bandage exhibits superior properties in multiple features and can be conformally adhered to the skin wound. In addition, the iSAFE can accurately assess the wound conditions in-situ and thus adaptively perform localized drug release. The results from both in vitro and in vivo studies on animals prove the validity of wound monitoring, wound healing boosting and intelligent closed-loop wound management. Clinical trials on patients across age 18 to 95 with various types of wounds are performed. These results all indicate the unique and universality of the reported technology for wound monitoring and management.
Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, stretchable electronic wound bandage (iSAFE) for intelligent wound management. This electronic bandage exhibits superior properties in multiple features and can be conformally adhered to the skin wound. In addition, the iSAFE can accurately assess the wound conditions in-situ and thus adaptively perform localized drug release. The results from both in vitro and in vivo studies on animals prove the validity of wound monitoring, wound healing boosting and intelligent closed-loop wound management. Clinical trials on patients across age 18 to 95 with various types of wounds are performed. These results all indicate the unique and universality of the reported technology for wound monitoring and management. Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.
Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, stretchable electronic wound bandage (iSAFE) for intelligent wound management. This electronic bandage exhibits superior properties in multiple features and can be conformally adhered to the skin wound. In addition, the iSAFE can accurately assess the wound conditions in-situ and thus adaptively perform localized drug release. The results from both in vitro and in vivo studies on animals prove the validity of wound monitoring, wound healing boosting and intelligent closed-loop wound management. Clinical trials on patients across age 18 to 95 with various types of wounds are performed. These results all indicate the unique and universality of the reported technology for wound monitoring and management.Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, stretchable electronic wound bandage (iSAFE) for intelligent wound management. This electronic bandage exhibits superior properties in multiple features and can be conformally adhered to the skin wound. In addition, the iSAFE can accurately assess the wound conditions in-situ and thus adaptively perform localized drug release. The results from both in vitro and in vivo studies on animals prove the validity of wound monitoring, wound healing boosting and intelligent closed-loop wound management. Clinical trials on patients across age 18 to 95 with various types of wounds are performed. These results all indicate the unique and universality of the reported technology for wound monitoring and management.
Abstract Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, stretchable electronic wound bandage (iSAFE) for intelligent wound management. This electronic bandage exhibits superior properties in multiple features and can be conformally adhered to the skin wound. In addition, the iSAFE can accurately assess the wound conditions in-situ and thus adaptively perform localized drug release. The results from both in vitro and in vivo studies on animals prove the validity of wound monitoring, wound healing boosting and intelligent closed-loop wound management. Clinical trials on patients across age 18 to 95 with various types of wounds are performed. These results all indicate the unique and universality of the reported technology for wound monitoring and management.
ArticleNumber 5782
Author Zhao, Guangyao
Yu, Xinge
Yiu, Chun Ki
Tao, Xiaoming
Gao, Zhan
Su, Jingyou
Hu, Yue
Chen, Zhenlin
Li, Dengfeng
Li, Jiyu
Zhang, Binbin
Xu, Guoqiang
Liu, Yiming
Zhou, Jingkun
Ma, Xiaohui
Guo, Fang
He, Xinxin
Yang, Yawen
Wu, Pengcheng
Ren, Kangning
Li, Jian
Chen, Yi
Li, Zhiyuan
Guo, Guihuan
Li, Heng
Zhang, Qiang
Chow, Lung
Wang, Jiachen
Yao, Kuanming
Yang, Rungong
Jiao, Yanli
Huang, Ya
Fang, Bo
Huang, Xingcan
Chu, Hongwei
Ma, Jie
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/40593825$$D View this record in MEDLINE/PubMed
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Snippet Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances...
Abstract Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent...
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639/166/985
639/166/987
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Adhesion
Adhesives
Adolescent
Adult
Aged
Aged, 80 and over
Animals
Bandages
Biomaterials
Biomedical materials
Biosensors
Clinical trials
Closed loops
Diabetes
Electronics
Female
Glucose
Humanities and Social Sciences
Humans
In vivo methods and tests
Infections
Male
Medical dressings
Mice
Middle Aged
Monitoring
multidisciplinary
Permeability
Real time
Science
Science (multidisciplinary)
Skin
Skin - injuries
Smartphones
Waterproofing
Wireless communications
Wound healing
Wound Healing - physiology
Young Adult
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Title A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage
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