Integrated analysis of the expression profiles of the lncRNA-miRNA-mRNA ceRNA network in CASMCs under hypoxia and normoxia conditions in yak heart

Hypoxia causes the occurrence of right heart hypertrophy and right heart failure. However, the yak living in the hypoxic environment, does not exhibit hypoxia-related pathological features. Therefore, It is of great significance to explore the hypoxia adaptation mechanism of yak heart. In this study...

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Bibliographic Details
Published in:	Scientific reports Vol. 15; no. 1; pp. 9165 - 15
Main Authors:	Yang, Shanshan, Cui, Yan, Yu, Sijiu, He, Junfeng, Ma, Rui, Bai, Xuefeng, Zhang, Hui, Zhao, Pengfei
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 17.03.2025 Nature Publishing Group Nature Portfolio
Subjects:	1-Phosphatidylinositol 3-kinase 631/181 631/208 631/337 631/443 631/80 Adaptation AKT protein Animals Cattle Cell Hypoxia CeRNA network Congestive heart failure Coronary vascular smooth muscle cells Coronary Vessels - cytology Coronary Vessels - metabolism Extracellular matrix Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Heart Humanities and Social Sciences Hypertrophy Hypoxia Hypoxia - genetics Hypoxic adaptation Immune system LncRNA MAP kinase MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism MiRNA Molecular modelling multidisciplinary Myocardium - metabolism Myocytes, Smooth Muscle - metabolism Non-coding RNA Regulatory sequences RNA, Competitive Endogenous RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Science Science (multidisciplinary) Smooth muscle TOR protein Transcription factors Transcriptome Transforming growth factor-b Yak LncRNA CeRNA network Yak Hypoxic adaptation Coronary vascular smooth muscle cells MiRNA
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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