Gentiopicroside improves DSS-induced ulcerative colitis and secondary liver injury in mice by enhancing the intestinal barrier and regulating the gut microbiome

Ulcerative colitis (UC) is a chronic inflammatory bowel disease frequently accompanied by intestinal barrier dysfunction and gut microbiome dysbiosis. Emerging evidence suggests that these impairments can contribute to secondary liver injury (SLI) by disrupting the gut–liver axis and promoting hepat...

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Bibliographic Details
Published in:	Scientific reports Vol. 15; no. 1; pp. 27159 - 16
Main Authors:	Cao, Liu, Niu, Mengyuan, Tang, Xiaoqing, Wang, Yiting, Hu, Xianjing, Dai, Weibo
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 25.07.2025 Nature Publishing Group Nature Portfolio
Subjects:	692/4020 692/699 Animals Body weight Chemical and Drug Induced Liver Injury - drug therapy Colitis, Ulcerative - chemically induced Colitis, Ulcerative - drug therapy Colitis, Ulcerative - metabolism Colitis, Ulcerative - microbiology Colitis, Ulcerative - pathology Colon Colon - drug effects Colon - pathology Cytokines Dextran Dextran sulfate Dextran Sulfate - adverse effects Diarrhea Digestive system Disease Models, Animal Drug dosages Dysbacteriosis Feces Gastrointestinal Microbiome - drug effects Gastrointestinal tract Gentiopicroside Glycosides Gut Microbiome Gut microbiota Histopathology Humanities and Social Sciences Inflammation Inflammatory bowel disease Inflammatory bowel diseases Intestinal barrier Intestinal microflora Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestine Iridoid Glucosides - pharmacology Iridoid Glucosides - therapeutic use Janus kinase 2 Kinases Laboratory animals Liver Liver - drug effects Liver - metabolism Liver - pathology Male Mice Mice, Inbred C57BL Microbiomes Microbiota Molecular weight multidisciplinary MyD88 protein NF-κB protein Phosphatase Protease inhibitors Protein composition Science Science (multidisciplinary) Secondary liver injury Signal Transduction - drug effects Stat3 protein TLR4 protein Toll-Like Receptor 4 - metabolism Toll-like receptors Traditional Chinese medicine Tumor necrosis factor-TNF Ulcerative colitis United States > US China Intestinal barrier Secondary liver injury Gut Microbiome Gentiopicroside Ulcerative colitis
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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