Unveiling the hidden interactome of CRBN molecular glues

Induced proximity by molecular glues refers to strategies that leverage the recruitment of proteins to facilitate their modification, regulation or degradation. As prospective design of molecular glues remains challenging, unbiased discovery methods are necessary to discover new chemical targets. He...

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Vydané v:Nature communications Ročník 16; číslo 1; s. 6831 - 18
Hlavní autori: Baek, Kheewoong, Metivier, Rebecca J., Roy Burman, Shourya S., Bushman, Jonathan W., Yoon, Hojong, Lumpkin, Ryan J., Ryan, Julia K., Abeja, Dinah M., Lakshminarayan, Megha, Yue, Hong, Ojeda, Samuel, Xiong, Yuan, Che, Jianwei, Verano, Alyssa L., Schmoker, Anna M., Gray, Nathanael S., Donovan, Katherine A., Fischer, Eric S.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London Nature Publishing Group UK 24.07.2025
Nature Publishing Group
Nature Portfolio
Predmet:
101/28
13
13/1
13/106
49/56
631/45/475/2290
631/92/507
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82/80
82/83
Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - metabolism
Adhesives
Biochemistry
Computer applications
Degradation
Glues
HEK293 Cells
Humanities and Social Sciences
Humans
Identification
Kinases
Lead compounds
Lysates
multidisciplinary
Peptide mapping
Protein Binding
Protein interaction
Proteins
Proteomics
Proteomics - methods
Science
Science (multidisciplinary)
Ubiquitin-protein ligase
Ubiquitin-Protein Ligases - genetics
Ubiquitin-Protein Ligases - metabolism
Workflow
Zinc finger proteins
ISSN:2041-1723, 2041-1723
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Abstract Induced proximity by molecular glues refers to strategies that leverage the recruitment of proteins to facilitate their modification, regulation or degradation. As prospective design of molecular glues remains challenging, unbiased discovery methods are necessary to discover new chemical targets. Here we establish a high throughput affinity proteomics workflow leveraging E3 ligase activity-impaired CRBN-DDB1ΔB in cell lysates for the unbiased identification of molecular glue targets. By mapping the interaction landscape of CRBN-binding molecular glues, we unveil 298 protein targets and demonstrate the utility of enrichment methods for identifying targets overlooked by established methods. We use a computational workflow to estimate target confidence and perform biochemical and structural validation of uncharacterized neo-substrates. We further identify a lead compound for the previously untargeted non-zinc finger PPIL4 through a biochemical screen. Our study provides a comprehensive inventory of targets chemically recruited to CRBN and delivers a robust and scalable workflow for identifying drug-induced protein interactions in cell lysates. Induced proximity by molecular glues is a strategy that leverages the recruitment of proteins to facilitate their modification or degradation. Here the authors present unbiased quantitative proteomic, biochemical and computational workflows that uncover hundreds of CRBN molecular glue targets using recombinant protein and cell lysate.
AbstractList Induced proximity by molecular glues refers to strategies that leverage the recruitment of proteins to facilitate their modification, regulation or degradation. As prospective design of molecular glues remains challenging, unbiased discovery methods are necessary to discover new chemical targets. Here we establish a high throughput affinity proteomics workflow leveraging E3 ligase activity-impaired CRBN-DDB1ΔB in cell lysates for the unbiased identification of molecular glue targets. By mapping the interaction landscape of CRBN-binding molecular glues, we unveil 298 protein targets and demonstrate the utility of enrichment methods for identifying targets overlooked by established methods. We use a computational workflow to estimate target confidence and perform biochemical and structural validation of uncharacterized neo-substrates. We further identify a lead compound for the previously untargeted non-zinc finger PPIL4 through a biochemical screen. Our study provides a comprehensive inventory of targets chemically recruited to CRBN and delivers a robust and scalable workflow for identifying drug-induced protein interactions in cell lysates.Induced proximity by molecular glues is a strategy that leverages the recruitment of proteins to facilitate their modification or degradation. Here the authors present unbiased quantitative proteomic, biochemical and computational workflows that uncover hundreds of CRBN molecular glue targets using recombinant protein and cell lysate.
Abstract Induced proximity by molecular glues refers to strategies that leverage the recruitment of proteins to facilitate their modification, regulation or degradation. As prospective design of molecular glues remains challenging, unbiased discovery methods are necessary to discover new chemical targets. Here we establish a high throughput affinity proteomics workflow leveraging E3 ligase activity-impaired CRBN-DDB1ΔB in cell lysates for the unbiased identification of molecular glue targets. By mapping the interaction landscape of CRBN-binding molecular glues, we unveil 298 protein targets and demonstrate the utility of enrichment methods for identifying targets overlooked by established methods. We use a computational workflow to estimate target confidence and perform biochemical and structural validation of uncharacterized neo-substrates. We further identify a lead compound for the previously untargeted non-zinc finger PPIL4 through a biochemical screen. Our study provides a comprehensive inventory of targets chemically recruited to CRBN and delivers a robust and scalable workflow for identifying drug-induced protein interactions in cell lysates.
Induced proximity by molecular glues refers to strategies that leverage the recruitment of proteins to facilitate their modification, regulation or degradation. As prospective design of molecular glues remains challenging, unbiased discovery methods are necessary to discover new chemical targets. Here we establish a high throughput affinity proteomics workflow leveraging E3 ligase activity-impaired CRBN-DDB1ΔB in cell lysates for the unbiased identification of molecular glue targets. By mapping the interaction landscape of CRBN-binding molecular glues, we unveil 298 protein targets and demonstrate the utility of enrichment methods for identifying targets overlooked by established methods. We use a computational workflow to estimate target confidence and perform biochemical and structural validation of uncharacterized neo-substrates. We further identify a lead compound for the previously untargeted non-zinc finger PPIL4 through a biochemical screen. Our study provides a comprehensive inventory of targets chemically recruited to CRBN and delivers a robust and scalable workflow for identifying drug-induced protein interactions in cell lysates. Induced proximity by molecular glues is a strategy that leverages the recruitment of proteins to facilitate their modification or degradation. Here the authors present unbiased quantitative proteomic, biochemical and computational workflows that uncover hundreds of CRBN molecular glue targets using recombinant protein and cell lysate.
Induced proximity by molecular glues refers to strategies that leverage the recruitment of proteins to facilitate their modification, regulation or degradation. As prospective design of molecular glues remains challenging, unbiased discovery methods are necessary to discover new chemical targets. Here we establish a high throughput affinity proteomics workflow leveraging E3 ligase activity-impaired CRBN-DDB1ΔB in cell lysates for the unbiased identification of molecular glue targets. By mapping the interaction landscape of CRBN-binding molecular glues, we unveil 298 protein targets and demonstrate the utility of enrichment methods for identifying targets overlooked by established methods. We use a computational workflow to estimate target confidence and perform biochemical and structural validation of uncharacterized neo-substrates. We further identify a lead compound for the previously untargeted non-zinc finger PPIL4 through a biochemical screen. Our study provides a comprehensive inventory of targets chemically recruited to CRBN and delivers a robust and scalable workflow for identifying drug-induced protein interactions in cell lysates.
Induced proximity by molecular glues refers to strategies that leverage the recruitment of proteins to facilitate their modification, regulation or degradation. As prospective design of molecular glues remains challenging, unbiased discovery methods are necessary to discover new chemical targets. Here we establish a high throughput affinity proteomics workflow leveraging E3 ligase activity-impaired CRBN-DDB1ΔB in cell lysates for the unbiased identification of molecular glue targets. By mapping the interaction landscape of CRBN-binding molecular glues, we unveil 298 protein targets and demonstrate the utility of enrichment methods for identifying targets overlooked by established methods. We use a computational workflow to estimate target confidence and perform biochemical and structural validation of uncharacterized neo-substrates. We further identify a lead compound for the previously untargeted non-zinc finger PPIL4 through a biochemical screen. Our study provides a comprehensive inventory of targets chemically recruited to CRBN and delivers a robust and scalable workflow for identifying drug-induced protein interactions in cell lysates.Induced proximity by molecular glues refers to strategies that leverage the recruitment of proteins to facilitate their modification, regulation or degradation. As prospective design of molecular glues remains challenging, unbiased discovery methods are necessary to discover new chemical targets. Here we establish a high throughput affinity proteomics workflow leveraging E3 ligase activity-impaired CRBN-DDB1ΔB in cell lysates for the unbiased identification of molecular glue targets. By mapping the interaction landscape of CRBN-binding molecular glues, we unveil 298 protein targets and demonstrate the utility of enrichment methods for identifying targets overlooked by established methods. We use a computational workflow to estimate target confidence and perform biochemical and structural validation of uncharacterized neo-substrates. We further identify a lead compound for the previously untargeted non-zinc finger PPIL4 through a biochemical screen. Our study provides a comprehensive inventory of targets chemically recruited to CRBN and delivers a robust and scalable workflow for identifying drug-induced protein interactions in cell lysates.
ArticleNumber 6831
Author Fischer, Eric S.
Baek, Kheewoong
Ojeda, Samuel
Donovan, Katherine A.
Lumpkin, Ryan J.
Metivier, Rebecca J.
Verano, Alyssa L.
Gray, Nathanael S.
Abeja, Dinah M.
Roy Burman, Shourya S.
Bushman, Jonathan W.
Schmoker, Anna M.
Che, Jianwei
Ryan, Julia K.
Yue, Hong
Xiong, Yuan
Lakshminarayan, Megha
Yoon, Hojong
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/40707481$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.sbi.2024.102811
10.1038/s41591-021-01572-7
10.1126/science.adt6736
10.1126/science.1244917
10.1016/j.chembiol.2017.09.010
10.1038/s41592-020-00998-0
10.1038/s41589-021-00802-w
10.1126/science.aat0572
10.1038/ncomms15398
10.1002/pro.2610
10.1021/jacs.4c06127
10.1002/pro.4548
10.1158/2643-3230.BCD-20-0105
10.1073/pnas.1814446115
10.1126/science.adk4422
10.1126/science.1177319
10.1038/s41467-021-27818-z
10.1038/nbt.2375
10.1038/s41592-020-0848-2
10.1021/ac502040v
10.1073/pnas.91.9.4082
10.1016/j.cell.2014.04.037
10.1038/s41467-020-18488-4
10.1016/j.chembiol.2021.07.002
10.1093/nar/gkv007
10.1126/science.add7574
10.1002/cpps.51
10.1038/s41589-018-0129-x
10.1146/annurev-pharmtox-022123-104147
10.1038/s41589-020-0645-3
10.1038/nature13527
10.1093/nar/gku1267
10.1002/prot.10613
10.1021/acs.jctc.1c00136
10.1016/S2352-3026(22)00290-3
10.1101/595389
10.1038/s41586-024-07089-6
10.1038/s41589-024-01590-9
10.1016/j.chembiol.2017.10.005
10.1038/s41573-021-00371-6
10.1093/nar/gkad1011
10.1182/blood-2018-01-821769
10.7554/elife.38430
10.1038/s41596-020-0399-0
10.1038/s41589-024-01668-4
10.1039/C3MD00315A
10.1016/j.cell.2020.10.038
10.1073/pnas.1406459111
10.1038/s41594-023-01206-1
10.1056/NEJMoa2303194
10.1146/annurev-pharmtox-010715-103507
10.1146/annurev-biochem-060310-170328
10.1038/nature18611
10.1016/j.chembiol.2023.02.008
10.1006/jmbi.2001.5080
10.1021/acscentsci.1c00389
10.1126/science.1244851
10.1038/nature16979
10.1016/j.cell.2015.06.043
10.1038/s41592-019-0638-x
10.1016/j.pharmthera.2017.02.027
10.1038/s41467-023-43326-8
10.1038/nature14610
10.1073/pnas.141230798
10.1038/cddiscovery.2017.71
10.1016/j.bbrc.2021.02.110
10.1091/mbc.E15-12-0844
10.1093/bioinformatics/bty355
10.1016/j.jbc.2022.101653
10.1016/j.omto.2020.06.013
10.1093/nar/gkac993
10.1093/bioinformatics/btu031
10.1038/s41586-023-06049-w
10.1016/j.molcel.2019.12.013
10.1016/j.chembiol.2019.02.019
10.1111/febs.17196
10.1016/j.tips.2023.08.007
10.1126/science.272.5265.1179
10.1038/nchembio.1858
10.1038/s41589-018-0055-y
10.7554/eLife.54983
10.1038/s42003-021-02399-1
10.1093/nar/gkac1000
10.1007/s00535-013-0931-x
10.1126/science.aab1433
10.1002/prot.26030
10.1021/acs.jmedchem.1c01832
10.1126/sciadv.adp3000
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References J Kronke (62099_CR5) 2014; 343
C Surka (62099_CR50) 2021; 137
MP Jacobson (62099_CR91) 2004; 55
J Zhou (62099_CR62) 2015; 24
J Liwocha (62099_CR70) 2024; 31
62099_CR40
KJ Roux (62099_CR35) 2018; 91
62099_CR80
62099_CR46
Y Gemechu (62099_CR51) 2018; 115
DP Bondeson (62099_CR27) 2018; 25
R Sanchez-Garcia (62099_CR93) 2021; 4
J Kronke (62099_CR17) 2015; 523
M Zhao (62099_CR60) 2021; 549
62099_CR89
M Golkowski (62099_CR44) 2014; 5
NA Marze (62099_CR90) 2018; 34
B Wang (62099_CR8) 2024; 86
K Kido (62099_CR38) 2020; 9
H Shibuya (62099_CR42) 1996; 272
DP Bondeson (62099_CR1) 2017; 57
GC McAlister (62099_CR88) 2014; 86
HT Huang (62099_CR23) 2018; 25
ME Matyskiela (62099_CR11) 2016; 535
J Zhang (62099_CR64) 2023; 32
V Demichev (62099_CR87) 2020; 17
H Furihata (62099_CR61) 2020; 11
62099_CR71
62099_CR74
EL Huttlin (62099_CR33) 2015; 162
QL Sievers (62099_CR16) 2018; 132
JD Martell (62099_CR39) 2012; 30
DC Scott (62099_CR83) 2014; 157
JA Mercer (62099_CR84) 2024; 383
KM Sakamoto (62099_CR3) 2001; 98
M Teng (62099_CR76) 2021; 65
ME Ritchie (62099_CR86) 2015; 43
62099_CR32
O Barroso-Gomila (62099_CR68) 2023; 14
S Yamanaka (62099_CR73) 2022; 13
T Barak (62099_CR81) 2021; 27
ME Matyskiela (62099_CR15) 2018; 14
J Gough (62099_CR58) 2001; 313
ES Wang (62099_CR53) 2021; 17
PR Hagner (62099_CR52) 2015; 126
62099_CR29
Y Xiong (62099_CR31) 2021; 28
G Petzold (62099_CR12) 2016; 532
P Jones (62099_CR55) 2014; 30
DI Kim (62099_CR37) 2016; 27
KF Cho (62099_CR34) 2020; 15
FP Rodriguez-Rivera (62099_CR67) 2021; 7
D Szklarczyk (62099_CR77) 2023; 51
U Mukhopadhyay (62099_CR69) 2024; 10
GE Winter (62099_CR6) 2015; 348
TK Neklesa (62099_CR2) 2017; 174
62099_CR26
EA King (62099_CR25) 2023; 30
J Yamamoto (62099_CR20) 2020; 16
L Li (62099_CR22) 2020; 18
O Hsia (62099_CR30) 2024; 627
RP Nowak (62099_CR28) 2018; 14
62099_CR19
YS Roh (62099_CR41) 2014; 49
T Paysan-Lafosse (62099_CR56) 2023; 51
V Oleinikovas (62099_CR14) 2024; 64
ER Watson (62099_CR85) 2022; 378
D Komander (62099_CR4) 2012; 81
JB Maguire (62099_CR66) 2021; 89
J Schmitzová (62099_CR78) 2023; 617
DP Bondeson (62099_CR7) 2015; 11
T Ito (62099_CR9) 2010; 327
A Renneville (62099_CR21) 2021; 2
DI Kim (62099_CR36) 2014; 111
M Varadi (62099_CR63) 2024; 52
62099_CR57
M Békés (62099_CR72) 2022; 21
RJ D’Amato (62099_CR47) 1994; 91
62099_CR59
62099_CR54
G Garivet (62099_CR43) 2019; 26
S Lonial (62099_CR48) 2022; 9
G Sathe (62099_CR24) 2023; 44
G Lu (62099_CR13) 2014; 343
JK Leman (62099_CR65) 2020; 17
PV Hornbeck (62099_CR79) 2015; 43
ES Fischer (62099_CR10) 2014; 512
J An (62099_CR18) 2017; 8
F Meier (62099_CR45) 2020; 17
EB Miller (62099_CR92) 2021; 17
PG Richardson (62099_CR49) 2023; 389
M Cassandri (62099_CR75) 2017; 3
KM Reichermeier (62099_CR82) 2020; 77
39314457 - bioRxiv. 2024 Oct 04:2024.09.11.612438. doi: 10.1101/2024.09.11.612438.
References_xml – volume: 86
  start-page: 102811
  year: 2024
  ident: 62099_CR8
  publication-title: Curr. Opin. Struct. Biol.
  doi: 10.1016/j.sbi.2024.102811
– volume: 27
  start-page: 2165
  year: 2021
  ident: 62099_CR81
  publication-title: Nat. Med.
  doi: 10.1038/s41591-021-01572-7
– ident: 62099_CR80
  doi: 10.1126/science.adt6736
– volume: 343
  start-page: 305
  year: 2014
  ident: 62099_CR13
  publication-title: Science
  doi: 10.1126/science.1244917
– volume: 25
  start-page: 78
  year: 2018
  ident: 62099_CR27
  publication-title: Cell Chem. Biol.
  doi: 10.1016/j.chembiol.2017.09.010
– volume: 17
  start-page: 1229
  year: 2020
  ident: 62099_CR45
  publication-title: Nat. Methods
  doi: 10.1038/s41592-020-00998-0
– volume: 17
  start-page: 711
  year: 2021
  ident: 62099_CR53
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/s41589-021-00802-w
– ident: 62099_CR40
  doi: 10.1126/science.aat0572
– volume: 8
  year: 2017
  ident: 62099_CR18
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms15398
– volume: 24
  start-page: 508
  year: 2015
  ident: 62099_CR62
  publication-title: Protein Sci.
  doi: 10.1002/pro.2610
– ident: 62099_CR59
  doi: 10.1021/jacs.4c06127
– volume: 32
  start-page: e4548
  year: 2023
  ident: 62099_CR64
  publication-title: Protein Sci.
  doi: 10.1002/pro.4548
– volume: 2
  start-page: 250
  year: 2021
  ident: 62099_CR21
  publication-title: Blood Cancer Discov.
  doi: 10.1158/2643-3230.BCD-20-0105
– volume: 115
  start-page: 11802
  year: 2018
  ident: 62099_CR51
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1814446115
– ident: 62099_CR89
– volume: 383
  year: 2024
  ident: 62099_CR84
  publication-title: Science
  doi: 10.1126/science.adk4422
– volume: 327
  start-page: 1345
  year: 2010
  ident: 62099_CR9
  publication-title: Science
  doi: 10.1126/science.1177319
– volume: 13
  year: 2022
  ident: 62099_CR73
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-27818-z
– ident: 62099_CR46
– volume: 30
  start-page: 1143
  year: 2012
  ident: 62099_CR39
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2375
– volume: 17
  start-page: 665
  year: 2020
  ident: 62099_CR65
  publication-title: Nat. Methods
  doi: 10.1038/s41592-020-0848-2
– volume: 86
  start-page: 7150
  year: 2014
  ident: 62099_CR88
  publication-title: Anal. Chem.
  doi: 10.1021/ac502040v
– volume: 91
  start-page: 4082
  year: 1994
  ident: 62099_CR47
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.91.9.4082
– volume: 157
  start-page: 1671
  year: 2014
  ident: 62099_CR83
  publication-title: Cell
  doi: 10.1016/j.cell.2014.04.037
– volume: 11
  year: 2020
  ident: 62099_CR61
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-18488-4
– volume: 28
  start-page: 1514
  year: 2021
  ident: 62099_CR31
  publication-title: Cell Chem. Biol.
  doi: 10.1016/j.chembiol.2021.07.002
– volume: 43
  start-page: e47
  year: 2015
  ident: 62099_CR86
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv007
– volume: 378
  start-page: 549
  year: 2022
  ident: 62099_CR85
  publication-title: Science
  doi: 10.1126/science.add7574
– volume: 91
  start-page: 19.23. 11
  year: 2018
  ident: 62099_CR35
  publication-title: Curr. Protoc. protein Sci.
  doi: 10.1002/cpps.51
– volume: 14
  start-page: 981
  year: 2018
  ident: 62099_CR15
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/s41589-018-0129-x
– volume: 64
  start-page: 291
  year: 2024
  ident: 62099_CR14
  publication-title: Annu. Rev. Pharmacol. Toxicol.
  doi: 10.1146/annurev-pharmtox-022123-104147
– volume: 16
  start-page: 1208
  year: 2020
  ident: 62099_CR20
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/s41589-020-0645-3
– volume: 512
  start-page: 49
  year: 2014
  ident: 62099_CR10
  publication-title: Nature
  doi: 10.1038/nature13527
– volume: 43
  start-page: D512
  year: 2015
  ident: 62099_CR79
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku1267
– volume: 55
  start-page: 351
  year: 2004
  ident: 62099_CR91
  publication-title: Proteins: Struct. Funct. Bioinform.
  doi: 10.1002/prot.10613
– volume: 17
  start-page: 2630
  year: 2021
  ident: 62099_CR92
  publication-title: J. Chem. Theory Comput.
  doi: 10.1021/acs.jctc.1c00136
– volume: 9
  start-page: e822
  year: 2022
  ident: 62099_CR48
  publication-title: Lancet Haematol.
  doi: 10.1016/S2352-3026(22)00290-3
– ident: 62099_CR74
  doi: 10.1101/595389
– volume: 627
  start-page: 204
  year: 2024
  ident: 62099_CR30
  publication-title: Nature
  doi: 10.1038/s41586-024-07089-6
– ident: 62099_CR32
  doi: 10.1038/s41589-024-01590-9
– volume: 25
  start-page: 88
  year: 2018
  ident: 62099_CR23
  publication-title: Cell Chem. Biol.
  doi: 10.1016/j.chembiol.2017.10.005
– volume: 21
  start-page: 181
  year: 2022
  ident: 62099_CR72
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/s41573-021-00371-6
– volume: 52
  start-page: D368
  year: 2024
  ident: 62099_CR63
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkad1011
– volume: 132
  start-page: 1293
  year: 2018
  ident: 62099_CR16
  publication-title: Blood
  doi: 10.1182/blood-2018-01-821769
– ident: 62099_CR19
  doi: 10.7554/elife.38430
– volume: 15
  start-page: 3971
  year: 2020
  ident: 62099_CR34
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-020-0399-0
– ident: 62099_CR57
– ident: 62099_CR29
  doi: 10.1038/s41589-024-01668-4
– volume: 5
  start-page: 363
  year: 2014
  ident: 62099_CR44
  publication-title: Medchemcomm
  doi: 10.1039/C3MD00315A
– ident: 62099_CR26
  doi: 10.1016/j.cell.2020.10.038
– volume: 111
  start-page: E2453
  year: 2014
  ident: 62099_CR36
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1406459111
– volume: 31
  start-page: 378
  year: 2024
  ident: 62099_CR70
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/s41594-023-01206-1
– volume: 389
  start-page: 1009
  year: 2023
  ident: 62099_CR49
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2303194
– volume: 57
  start-page: 107
  year: 2017
  ident: 62099_CR1
  publication-title: Annu. Rev. Pharmacol. Toxicol.
  doi: 10.1146/annurev-pharmtox-010715-103507
– volume: 81
  start-page: 203
  year: 2012
  ident: 62099_CR4
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev-biochem-060310-170328
– volume: 535
  start-page: 252
  year: 2016
  ident: 62099_CR11
  publication-title: Nature
  doi: 10.1038/nature18611
– volume: 30
  start-page: 394
  year: 2023
  ident: 62099_CR25
  publication-title: Cell Chem. Biol.
  doi: 10.1016/j.chembiol.2023.02.008
– volume: 313
  start-page: 903
  year: 2001
  ident: 62099_CR58
  publication-title: J. Mol. Biol.
  doi: 10.1006/jmbi.2001.5080
– volume: 7
  start-page: 1117
  year: 2021
  ident: 62099_CR67
  publication-title: ACS Cent. Sci.
  doi: 10.1021/acscentsci.1c00389
– volume: 343
  start-page: 301
  year: 2014
  ident: 62099_CR5
  publication-title: Science
  doi: 10.1126/science.1244851
– volume: 532
  start-page: 127
  year: 2016
  ident: 62099_CR12
  publication-title: Nature
  doi: 10.1038/nature16979
– volume: 162
  start-page: 425
  year: 2015
  ident: 62099_CR33
  publication-title: Cell
  doi: 10.1016/j.cell.2015.06.043
– volume: 17
  start-page: 41
  year: 2020
  ident: 62099_CR87
  publication-title: Nat. Methods
  doi: 10.1038/s41592-019-0638-x
– volume: 174
  start-page: 138
  year: 2017
  ident: 62099_CR2
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2017.02.027
– volume: 14
  year: 2023
  ident: 62099_CR68
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-43326-8
– volume: 523
  start-page: 183
  year: 2015
  ident: 62099_CR17
  publication-title: Nature
  doi: 10.1038/nature14610
– volume: 98
  start-page: 8554
  year: 2001
  ident: 62099_CR3
  publication-title: Proc. Natl. Acad. Sci.
  doi: 10.1073/pnas.141230798
– volume: 3
  start-page: 1
  year: 2017
  ident: 62099_CR75
  publication-title: Cell Death Discov.
  doi: 10.1038/cddiscovery.2017.71
– volume: 549
  start-page: 150
  year: 2021
  ident: 62099_CR60
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2021.02.110
– volume: 27
  start-page: 1188
  year: 2016
  ident: 62099_CR37
  publication-title: Mol. Biol. cell
  doi: 10.1091/mbc.E15-12-0844
– volume: 34
  start-page: 3461
  year: 2018
  ident: 62099_CR90
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bty355
– ident: 62099_CR71
  doi: 10.1016/j.jbc.2022.101653
– volume: 18
  start-page: 215
  year: 2020
  ident: 62099_CR22
  publication-title: Mol. Ther. Oncolytics
  doi: 10.1016/j.omto.2020.06.013
– volume: 51
  start-page: D418
  year: 2023
  ident: 62099_CR56
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkac993
– volume: 137
  start-page: 661
  year: 2021
  ident: 62099_CR50
  publication-title: Blood, J. Am. Soc. Hematol.
– volume: 126
  start-page: 779
  year: 2015
  ident: 62099_CR52
  publication-title: Blood, J. Am. Soc. Hematol.
– volume: 30
  start-page: 1236
  year: 2014
  ident: 62099_CR55
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu031
– volume: 617
  start-page: 842
  year: 2023
  ident: 62099_CR78
  publication-title: Nature
  doi: 10.1038/s41586-023-06049-w
– volume: 77
  start-page: 1092
  year: 2020
  ident: 62099_CR82
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2019.12.013
– volume: 26
  start-page: 842
  year: 2019
  ident: 62099_CR43
  publication-title: Cell Chem. Biol.
  doi: 10.1016/j.chembiol.2019.02.019
– ident: 62099_CR54
  doi: 10.1111/febs.17196
– volume: 44
  start-page: 786
  year: 2023
  ident: 62099_CR24
  publication-title: Trends Pharmacol. Sci.
  doi: 10.1016/j.tips.2023.08.007
– volume: 272
  start-page: 1179
  year: 1996
  ident: 62099_CR42
  publication-title: Science
  doi: 10.1126/science.272.5265.1179
– volume: 11
  start-page: 611
  year: 2015
  ident: 62099_CR7
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.1858
– volume: 14
  start-page: 706
  year: 2018
  ident: 62099_CR28
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/s41589-018-0055-y
– volume: 9
  year: 2020
  ident: 62099_CR38
  publication-title: Elife
  doi: 10.7554/eLife.54983
– volume: 4
  start-page: 874
  year: 2021
  ident: 62099_CR93
  publication-title: Commun. Biol.
  doi: 10.1038/s42003-021-02399-1
– volume: 51
  start-page: D638
  year: 2023
  ident: 62099_CR77
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkac1000
– volume: 49
  start-page: 185
  year: 2014
  ident: 62099_CR41
  publication-title: J. Gastroenterol.
  doi: 10.1007/s00535-013-0931-x
– volume: 348
  start-page: 1376
  year: 2015
  ident: 62099_CR6
  publication-title: Science
  doi: 10.1126/science.aab1433
– volume: 89
  start-page: 436
  year: 2021
  ident: 62099_CR66
  publication-title: Proteins Struct. Funct. Bioinform.
  doi: 10.1002/prot.26030
– volume: 65
  start-page: 747
  year: 2021
  ident: 62099_CR76
  publication-title: J. Med. Chem.
  doi: 10.1021/acs.jmedchem.1c01832
– volume: 10
  year: 2024
  ident: 62099_CR69
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.adp3000
– reference: 39314457 - bioRxiv. 2024 Oct 04:2024.09.11.612438. doi: 10.1101/2024.09.11.612438.
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Snippet Induced proximity by molecular glues refers to strategies that leverage the recruitment of proteins to facilitate their modification, regulation or...
Abstract Induced proximity by molecular glues refers to strategies that leverage the recruitment of proteins to facilitate their modification, regulation or...
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Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - metabolism
Adhesives
Biochemistry
Computer applications
Degradation
Glues
HEK293 Cells
Humanities and Social Sciences
Humans
Identification
Kinases
Lead compounds
Lysates
multidisciplinary
Peptide mapping
Protein Binding
Protein interaction
Proteins
Proteomics
Proteomics - methods
Science
Science (multidisciplinary)
Ubiquitin-protein ligase
Ubiquitin-Protein Ligases - genetics
Ubiquitin-Protein Ligases - metabolism
Workflow
Zinc finger proteins
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Title Unveiling the hidden interactome of CRBN molecular glues
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