TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties

TG02 is a novel pyrimidine-based multi-kinase inhibitor that inhibits CDKs 1, 2, 7 and 9 together with JAK2 and FLT3. It dose-dependently inhibits signaling pathways downstream of CDKs, JAK2 and FLT3 in cancer cells with the main targets being CDKs. TG02 is anti-proliferative in a broad range of tum...

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Veröffentlicht in:	Leukemia Jg. 26; H. 2; S. 236 - 243
Hauptverfasser:	Goh, K C, Novotny-Diermayr, V, Hart, S, Ong, L C, Loh, Y K, Cheong, A, Tan, Y C, Hu, C, Jayaraman, R, William, A D, Sun, E T, Dymock, B W, Ong, K H, Ethirajulu, K, Burrows, F, Wood, J M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.02.2012 Nature Publishing Group
Schlagworte:	Acute myeloid leukemia Animal models Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Bioaccumulation Biological and medical sciences Cancer Cancer Research Care and treatment Cell cycle Cell Line, Transformed Cells (biology) Critical Care Medicine Cyclin-dependent kinase Cyclin-dependent kinases Cyclin-Dependent Kinases - antagonists & inhibitors Disease Models, Animal Dosage Dosage and administration Enzyme inhibitors Female fms-Like Tyrosine Kinase 3 - antagonists & inhibitors Hematologic and hematopoietic diseases Hematology Heterocyclic Compounds, 4 or More Rings - pharmacology Heterocyclic Compounds, 4 or More Rings - therapeutic use Humans Intensive Internal Medicine Janus kinase 2 Janus Kinase 2 - antagonists & inhibitors Kinases Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical prognosis Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred BALB C Oncology original-article Patients Pharmacokinetics Polycythemia Polycythemia vera Progenitor cells Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Signaling Stem cells Tumor cell lines Tumors Xenografts Xenotransplantation Singapore United States > US multi-kinase inhibitor AML TG02 CDK JAK2 FLT3 Acute myelogenous leukemia Hematology Enzyme FLT3 gene JAK2 protein tyrosine kinase Transferases Malignant hemopathy trk receptor Cyclin dependent kinase inhibitor Kinase C-Onc gene Protein-tyrosine kinase Protooncogene Cancer
ISSN:	0887-6924, 1476-5551, 1476-5551
Online-Zugang:	Volltext
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