Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans

Elevated lipoprotein(a) [Lp(a)] is a prevalent, independent cardiovascular risk factor, but the underlying mechanisms responsible for its pathogenicity are poorly defined. Because Lp(a) is the prominent carrier of proinflammatory oxidized phospholipids (OxPLs), part of its atherothrombosis might be...

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Bibliographic Details
Published in:	Circulation (New York, N.Y.) Vol. 134; no. 8; p. 611
Main Authors:	van der Valk, Fleur M, Bekkering, Siroon, Kroon, Jeffrey, Yeang, Calvin, Van den Bossche, Jan, van Buul, Jaap D, Ravandi, Amir, Nederveen, Aart J, Verberne, Hein J, Scipione, Corey, Nieuwdorp, Max, Joosten, Leo A B, Netea, Mihai G, Koschinsky, Marlys L, Witztum, Joseph L, Tsimikas, Sotirios, Riksen, Niels P, Stroes, Erik S G
Format:	Journal Article
Language:	English
Published:	United States 23.08.2016
Subjects:	Adult Aged Aorta - diagnostic imaging Aorta - metabolism Cell Movement - physiology Cells, Cultured Female Humans Inflammation - diagnostic imaging Inflammation - metabolism Inflammation Mediators - metabolism Leukocytes, Mononuclear - metabolism Lipoprotein(a) - metabolism Male Middle Aged Phospholipids - metabolism Positron Emission Tomography Computed Tomography atherosclerosis monocytes lipoproteins
ISSN:	1524-4539, 1524-4539
Online Access:	Get more information
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