Enhanced Drug Delivery by Dissolution of Amorphous Drug Encapsulated in a Water Unstable Metal–Organic Framework (MOF)

Encapsulating a drug molecule into a water‐reactive metal–organic framework (MOF) leads to amorphous drug confined within the nanoscale pores. Rapid release of drug occurs upon hydrolytic decomposition of MOF in dissolution media. Application to improve dissolution and solubility for the hydrophobic...

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Bibliographic Details
Published in:	Angewandte Chemie (International ed.) Vol. 58; no. 47; pp. 16790 - 16794
Main Authors:	Suresh, Kuthuru, Matzger, Adam J.
Format:	Journal Article
Language:	English
Published:	Germany Wiley Subscription Services, Inc 18.11.2019 Wiley Blackwell (John Wiley & Sons)
Edition:	International ed. in English
Subjects:	amorphous drug Collapse Crystallization Curcumin Dissolution Drug delivery Drug delivery systems Encapsulation Hydrophobicity immediate drug release Metal-organic frameworks metal–organic framework stability Sulindac Supersaturation amorphous drug drug delivery immediate drug release stability metal-organic framework
ISSN:	1433-7851, 1521-3773, 1521-3773
Online Access:	Get full text
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