Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress

Filamentous actin (F-actin) provides cells with mechanical support and promotes the mobility of intracellular structures. Although F-actin is traditionally considered to be cytoplasmic, here we reveal that nuclear F-actin participates in the replication stress response. Using live and super-resoluti...

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Veröffentlicht in:	Nature cell biology Jg. 22; H. 12; S. 1460 - 1470
Hauptverfasser:	Lamm, Noa, Read, Mark N, Nobis, Max, Van Ly, David, Page, Scott G, Masamsetti, V Pragathi, Timpson, Paul, Biro, Maté, Cesare, Anthony J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Nature Publishing Group 01.12.2020
Schlagworte:	Abnormalities Actin Actin Cytoskeleton - metabolism Actins - genetics Actins - metabolism Animals Antineoplastic Agents - pharmacology Carboplatin - pharmacology Cell Line Cell Line, Tumor Cell Nucleus - genetics Cell Nucleus - metabolism Chemotherapy Chromosomes DNA Repair - genetics DNA Replication - genetics Filaments Humans Image resolution IQGAP1 protein Mechanistic Target of Rapamycin Complex 1 - genetics Mechanistic Target of Rapamycin Complex 1 - metabolism Mice, Inbred NOD Mice, Knockout Mice, SCID Mobility Myosin Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Nuclear deformation Nucleation Polymerization Repair Replication TOR protein Tumors Xenograft Model Antitumor Assays - methods Xenografts Xenotransplantation
ISSN:	1465-7392, 1476-4679, 1476-4679
Online-Zugang:	Volltext
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