Low pathogenicity H5N2 avian influenza outbreak in Japan during the 2005–2006

At the end of May 2005, a low-pathogenicity avian influenza (LPAI) virus of subtype H5N2 was isolated for the first time from chickens in Japan. Through active and epidemiological surveillance, 5.78 million chickens on 41 farms were found to be affected and 16 H5N2 viruses were isolated. Antigenic a...

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Published in:Veterinary microbiology Vol. 124; no. 1; pp. 35 - 46
Main Authors: Okamatsu, Masatoshi, Saito, Takehiko, Yamamoto, Yu, Mase, Masaji, Tsuduku, Satoko, Nakamura, Kikuyasu, Tsukamoto, Kenji, Yamaguchi, Shigeo
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 20.09.2007
Elsevier Science
Subjects:
adaptation
airborne microorganisms
Animals
Antigenic Variation
Antigenicity
Avian influenza
Base Sequence
Biological and medical sciences
Cells, Cultured
Chickens
Cluster Analysis
disease outbreaks
Disease Outbreaks - veterinary
disease surveillance
disease transmission
epidemiological studies
Epidemiology
Fundamental and applied biological sciences. Psychology
H5N2
Influenza A virus
Influenza A Virus, H5N2 Subtype - classification
Influenza A Virus, H5N2 Subtype - genetics
Influenza A Virus, H5N2 Subtype - immunology
Influenza A Virus, H5N2 Subtype - pathogenicity
Influenza in Birds - epidemiology
Influenza in Birds - transmission
Influenza in Birds - virology
Japan
Japan - epidemiology
Microbiology
molecular epidemiology
Molecular Sequence Data
pathogen identification
pathotypes
Phylogenetic analysis
Phylogeny
Polymerase Chain Reaction - methods
Polymerase Chain Reaction - veterinary
respiratory tract diseases
RNA, Viral - chemistry
serotypes
Species Specificity
Specific Pathogen-Free Organisms
Temperature
Transmission
Virology
virulence
Virus Replication
virus transmission
Japan
Asia
Avian influenza
H5N2
Phylogenetic analysis
Antigenicity
Transmission
Orthomyxoviridae
Zoopathogen
Phylogeny
Epidemiology
Infection
Virus
Pathogenicity
Influenzavirus A
Avian influenzavirus
Viral disease
ISSN:0378-1135, 1873-2542
Online Access:Get full text
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Summary:At the end of May 2005, a low-pathogenicity avian influenza (LPAI) virus of subtype H5N2 was isolated for the first time from chickens in Japan. Through active and epidemiological surveillance, 5.78 million chickens on 41 farms were found to be affected and 16 H5N2 viruses were isolated. Antigenic analysis revealed antigenic similarity of these isolates. Phylogenetic analysis showed that they originated from a common ancestor and clustered with the H5N2 strains prevalent in Central America that have been circulating since 1994. Experimental infection of chickens with the index isolate (A/chicken/Ibaraki/1/05) demonstrated that this virus replicated efficiently in the respiratory tract without clinical signs, and dust-borne and/or droplet-borne transmission was considered as a possible mode of transmission. These results suggested that the H5N2 LPAI viruses isolated in Japan were highly adapted to chickens.
Bibliography:http://dx.doi.org/10.1016/j.vetmic.2007.04.025
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ISSN:0378-1135
1873-2542
DOI:10.1016/j.vetmic.2007.04.025