An atlas of the protein-coding genes in the human, pig, and mouse brain

The brain, with its diverse physiology and intricate cellular organization, is the most complex organ of the mammalian body. To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissection of 10 major brain regions and multiple s...

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Podrobná bibliografie
Vydáno v:	Science (American Association for the Advancement of Science) Ročník 367; číslo 6482
Hlavní autoři:	Sjöstedt, Evelina, Zhong, Wen, Fagerberg, Linn, Karlsson, Max, Mitsios, Nicholas, Adori, Csaba, Oksvold, Per, Edfors, Fredrik, Limiszewska, Agnieszka, Hikmet, Feria, Huang, Jinrong, Du, Yutao, Lin, Lin, Dong, Zhanying, Yang, Ling, Liu, Xin, Jiang, Hui, Xu, Xun, Wang, Jian, Yang, Huanming, Bolund, Lars, Mardinoglu, Adil, Zhang, Cheng, von Feilitzen, Kalle, Lindskog, Cecilia, Pontén, Fredrik, Luo, Yonglun, Hökfelt, Tomas, Uhlén, Mathias, Mulder, Jan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 06.03.2020
Témata:	Animals Atlases as Topic Brain - physiology Datasets as Topic Female Gene Expression Regulation Humans Male Mice Mice, Inbred C57BL Nerve Tissue Proteins - genetics Organ Specificity - genetics Species Specificity Swine Transcriptome
ISSN:	1095-9203, 1095-9203
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Popis
Shrnutí:	The brain, with its diverse physiology and intricate cellular organization, is the most complex organ of the mammalian body. To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissection of 10 major brain regions and multiple subregions using a variety of transcriptomics methods and antibody-based mapping. This analysis was carried out in the human, pig, and mouse brain to allow the identification of regional expression profiles, as well as to study similarities and differences in expression levels between the three species. The resulting data have been made available in an open-access Brain Atlas resource, part of the Human Protein Atlas, to allow exploration and comparison of the expression of individual protein-coding genes in various parts of the mammalian brain.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	1095-9203 1095-9203
DOI:	10.1126/science.aay5947