Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus

In hepatitis C virus infection, replication of the viral genome and virion assembly are linked to cellular metabolic processes. In particular, lipid droplets, which store principally triacylglycerides (TAGs) and cholesterol esters (CEs), have been implicated in production of infectious virus. Here,...

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Vydané v:	The Journal of biological chemistry Ročník 289; číslo 31; s. 21276
Hlavní autori:	Liefhebber, Jolanda M P, Hague, Charlotte V, Zhang, Qifeng, Wakelam, Michael J O, McLauchlan, John
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.08.2014
Predmet:	Cell Line Cholesterol Esters - biosynthesis Fluorescent Antibody Technique, Indirect Hepacivirus - genetics Hepacivirus - physiology Humans RNA, Viral - biosynthesis Triglycerides - biosynthesis Virion Virus Assembly Lipid Droplet Hepatitis Virus Triglyceride Virus Assembly Cholesterol Hepatitis C Virus (HCV)
ISSN:	1083-351X, 1083-351X
On-line prístup:	Zistit podrobnosti o prístupe
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