Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus

In hepatitis C virus infection, replication of the viral genome and virion assembly are linked to cellular metabolic processes. In particular, lipid droplets, which store principally triacylglycerides (TAGs) and cholesterol esters (CEs), have been implicated in production of infectious virus. Here,...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 289; no. 31; p. 21276
Main Authors:	Liefhebber, Jolanda M P, Hague, Charlotte V, Zhang, Qifeng, Wakelam, Michael J O, McLauchlan, John
Format:	Journal Article
Language:	English
Published:	United States 01.08.2014
Subjects:	Cell Line Cholesterol Esters - biosynthesis Fluorescent Antibody Technique, Indirect Hepacivirus - genetics Hepacivirus - physiology Humans RNA, Viral - biosynthesis Triglycerides - biosynthesis Virion Virus Assembly Lipid Droplet Hepatitis Virus Triglyceride Virus Assembly Cholesterol Hepatitis C Virus (HCV)
ISSN:	1083-351X, 1083-351X
Online Access:	Get more information
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