Metformin alleviates allergic airway inflammation and increases Treg cells in obese asthma

Obesity increases the morbidity and severity of asthma, with poor sensitivity to corticosteroid treatment. Metformin has potential effects on improving asthma airway inflammation. Regulatory T cells (Tregs) play a key role in suppressing the immunoreaction to allergens. We built an obese asthmatic m...

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Bibliographic Details
Published in:	Journal of cellular and molecular medicine Vol. 25; no. 4; pp. 2279 - 2284
Main Authors:	Guo, Yimin, Shi, Jianting, Wang, Qiujie, Hong, Luna, Chen, Ming, Liu, Shanying, Yuan, Xiaoqing, Jiang, Shanping
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01.02.2021 John Wiley and Sons Inc
Subjects:	Allergens Animals Anti-Inflammatory Agents - pharmacology Antidiabetics Asthma Asthma - drug therapy Asthma - immunology Asthma - pathology Binding sites Body weight Body Weight - drug effects Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - immunology CD4 Lymphocyte Count Cholesterol Corticosteroids Cytokines Diet, High-Fat Disease Models, Animal Enzyme-linked immunosorbent assay Flow cytometry High fat diet Humans Hypoglycemic Agents - pharmacology Immunoregulation Inflammation Interleukin-4 - antagonists & inhibitors Interleukin-4 - immunology Interleukin-4 - metabolism Lipoproteins Lung - drug effects Lung - immunology Lung - pathology Lymphocytes T Metformin Metformin - pharmacology Mice Morbidity Obese asthma Obesity Obesity - drug therapy Obesity - immunology Obesity - pathology Ovalbumin Ovalbumin - administration & dosage Respiratory tract Respiratory tract diseases Short Communication Short Communications Software Spleen Spleen - drug effects Spleen - immunology Spleen - pathology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Transcription Transcription factors Tregs Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism Tregs Obese asthma Metformin
ISSN:	1582-1838, 1582-4934, 1582-4934
Online Access:	Get full text
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