Characteristics of long COVID and the impact of COVID-19 vaccination on long COVID 2 years following COVID-19 infection: prospective cohort study

This prospective cohort study aimed to identify characteristics of long COVID and any potential mitigating effects of COVID-19 vaccinations in patients 24 months following COVID-19 infection. Adult patients diagnosed with COVID-19 between February 17, 2020, and March 24, 2020, were scheduled to visi...

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Vydáno v:Scientific reports Ročník 14; číslo 1; s. 854 - 12
Hlavní autoři: Kim, Yoonjung, Bae, Sohyun, Chang, Hyun-Ha, Kim, Shin-Woo
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 09.01.2024
Nature Publishing Group
Nature Portfolio
Témata:
692/308/409
692/699/255
Adult
Amnesia
Cohort analysis
COVID-19
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 Vaccines
Female
Humanities and Social Sciences
Humans
Immunization
Infections
Long COVID
Male
Mental health
Middle Aged
multidisciplinary
Post-Acute COVID-19 Syndrome
Prospective Studies
Quality of Life
Science
Science (multidisciplinary)
Sleep disorders
Vaccination
ISSN:2045-2322, 2045-2322
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Popis
Shrnutí:This prospective cohort study aimed to identify characteristics of long COVID and any potential mitigating effects of COVID-19 vaccinations in patients 24 months following COVID-19 infection. Adult patients diagnosed with COVID-19 between February 17, 2020, and March 24, 2020, were scheduled to visit the study hospital four times (6, 12, 18, and 24 months after infection) to assess their symptoms, quality of life, and mental health. Among the 235 patients, 121 (51.5%) completed the study visits. Of these, 59.5% were female, with a median age of 52 years. Mild to moderate disease severity were identified in 101 (83.4%) patients. A total of 75 participants (62.0%) were still experiencing long COVID symptoms 24 months after acute infection. Fatigue, amnesia, difficulty concentrating, and insomnia were the most common symptoms. The frequency of neuropsychiatric symptoms did not differ based on vaccination status or the number of doses received. Quality of life improved over time for the participants, but 32.2% of respondents still reported anxiety/depression at the end of the study. Overall, our cohort demonstrates that long COVID can persist up to 24 months after COVID-19 infection, affecting mental health and quality of life.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-50024-4