A specific folate activates serotonergic neurons to control C. elegans behavior

Folates are B-group vitamins that function in one-carbon metabolism. Here we show that a specific folate can activate serotonergic neurons in C. elegans to modulate behavior through a pathway that requires the folate receptor FOLR-1 and the GON-2 calcium channel. FOLR-1 and GON-2 physically interact...

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Veröffentlicht in:	Nature communications Jg. 15; H. 1; S. 8471 - 16
Hauptverfasser:	Peesapati, Ria S., Austin-Byler, Brianna L., Nawaz, Fathima Zahra, Stevenson, Jonathan B., Mais, Stanelle A., Kaya, Rabia N., Hassan, Michael G., Khanal, Nabraj, Wells, Alexandra C., Ghiai, Deena, Garikapati, Anish K., Selhub, Jacob, Kipreos, Edward T.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 30.09.2024 Nature Publishing Group Nature Portfolio
Schlagworte:	14/19 14/35 14/63 631/378 631/378/1804 631/80/86/2369 64/11 82/1 82/29 96/106 Animals Behavior, Animal - drug effects Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Calcium (dietary) Calcium - metabolism Calcium channels Calcium Channels - metabolism Calcium ions Calcium signalling Carbon Egg laying Embryogenesis Embryonic growth stage Folate Receptor 1 - genetics Folate Receptor 1 - metabolism Folic acid Folic Acid - metabolism Humanities and Social Sciences Metabolism multidisciplinary Neurons Receptors Science Science (multidisciplinary) Serotonergic Neurons - drug effects Serotonergic Neurons - metabolism Serotonin Vitamin B Vitamins
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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