A specific folate activates serotonergic neurons to control C. elegans behavior

Folates are B-group vitamins that function in one-carbon metabolism. Here we show that a specific folate can activate serotonergic neurons in C. elegans to modulate behavior through a pathway that requires the folate receptor FOLR-1 and the GON-2 calcium channel. FOLR-1 and GON-2 physically interact...

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Vydáno v:Nature communications Ročník 15; číslo 1; s. 8471 - 16
Hlavní autoři: Peesapati, Ria S., Austin-Byler, Brianna L., Nawaz, Fathima Zahra, Stevenson, Jonathan B., Mais, Stanelle A., Kaya, Rabia N., Hassan, Michael G., Khanal, Nabraj, Wells, Alexandra C., Ghiai, Deena, Garikapati, Anish K., Selhub, Jacob, Kipreos, Edward T.
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 30.09.2024
Nature Publishing Group
Nature Portfolio
Témata:
14/19
14/35
14/63
631/378
631/378/1804
631/80/86/2369
64/11
82/1
82/29
96/106
Animals
Behavior, Animal - drug effects
Caenorhabditis elegans - metabolism
Caenorhabditis elegans Proteins - genetics
Caenorhabditis elegans Proteins - metabolism
Calcium (dietary)
Calcium - metabolism
Calcium channels
Calcium Channels - metabolism
Calcium ions
Calcium signalling
Carbon
Egg laying
Embryogenesis
Embryonic growth stage
Folate Receptor 1 - genetics
Folate Receptor 1 - metabolism
Folic acid
Folic Acid - metabolism
Humanities and Social Sciences
Metabolism
multidisciplinary
Neurons
Receptors
Science
Science (multidisciplinary)
Serotonergic Neurons - drug effects
Serotonergic Neurons - metabolism
Serotonin
Vitamin B
Vitamins
ISSN:2041-1723, 2041-1723
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Shrnutí:Folates are B-group vitamins that function in one-carbon metabolism. Here we show that a specific folate can activate serotonergic neurons in C. elegans to modulate behavior through a pathway that requires the folate receptor FOLR-1 and the GON-2 calcium channel. FOLR-1 and GON-2 physically interact in a heterologous system, and both are expressed in the HSN and NSM serotonergic neurons. Both the folate 10-formyl-THF and a non-metabolic pteroate induce increases in the number of Ca 2+ transients in the HSN neurons and egg laying in an FOLR-1- and GON-2-dependent manner. FOLR-1 and GON-2 are required for the activation of the NSM neurons in response to 10-formyl-THF, and for full NSM-mediated stoppage of movement when starved animals encounter bacteria. Our results demonstrate that FOLR-1 acts independently of one-carbon metabolism and suggest that 10-formyl-THF acts as a dietary signal that activates serotonergic neurons to impact behavior through a pathway that involves calcium entry. Folates are B vitamins that are known to be important for embryonic development and other important processes. Here, the authors show that a specific folate acts as a signal to activate serotonergic neurons to control behavior in C. elegans via a metabolism-independent pathway that requires the folate receptor and a calcium channel.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-024-52738-z