Risk of COVID-19 death in adults who received booster COVID-19 vaccinations in England

The emergence of the COVID-19 vaccination has been critical in changing the course of the COVID-19 pandemic. To ensure protection remains high in vulnerable groups booster vaccinations in the UK have been targeted based on age and clinical vulnerabilities. We undertook a national retrospective cohor...

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Veröffentlicht in:	Nature communications Jg. 15; H. 1; S. 398 - 6
Hauptverfasser:	Ward, Isobel L., Robertson, Chris, Agrawal, Utkarsh, Patterson, Lynsey, Bradley, Declan T., Shi, Ting, de Lusignan, Simon, Hobbs, F. D. Richard, Sheikh, Aziz, Nafilyan, Vahé
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 16.01.2024 Nature Publishing Group Nature Portfolio
Schlagworte:	631/326/596/2562 631/326/596/4130 692/499 692/699/255/2514 Adult Adults At risk populations Autoimmune diseases Blood Blood cancer Bone cancer Bone marrow Cancer Chronic conditions Cirrhosis COVID-19 COVID-19 - epidemiology COVID-19 - prevention & control COVID-19 Vaccines Cystic fibrosis Death Dementia disorders Down's syndrome Electronic health records Electronic medical records England - epidemiology Humanities and Social Sciences Humans Huntingtons disease Hypertension Hypotension Immunization Kidney diseases Liver Cirrhosis Lung cancer Lung diseases Mortality Motor neuron diseases Mouth Neoplasms Movement disorders multidisciplinary Multiple sclerosis Myasthenia gravis Neurodegenerative diseases Neuromuscular junctions Oral cancer Pandemics Parkinson's disease Retrospective Studies Rheumatoid arthritis Risk Science Science (multidisciplinary) Systemic lupus erythematosus England United Kingdom > UK
ISSN:	2041-1723, 2041-1723
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Zusammenfassung:	The emergence of the COVID-19 vaccination has been critical in changing the course of the COVID-19 pandemic. To ensure protection remains high in vulnerable groups booster vaccinations in the UK have been targeted based on age and clinical vulnerabilities. We undertook a national retrospective cohort study using data from the 2021 Census linked to electronic health records. We fitted cause-specific Cox models to examine the association between health conditions and the risk of COVID-19 death and all-other-cause death for adults aged 50-100-years in England vaccinated with a booster in autumn 2022. Here we show, having learning disabilities or Down Syndrome (hazard ratio=5.07;95% confidence interval=3.69-6.98), pulmonary hypertension or fibrosis (2.88;2.43-3.40), motor neuron disease, multiple sclerosis, myasthenia or Huntington’s disease (2.94, 1.82-4.74), cancer of blood and bone marrow (3.11;2.72-3.56), Parkinson’s disease (2.74;2.34-3.20), lung or oral cancer (2.57;2.04 to 3.24), dementia (2.64;2.46 to 2.83) or liver cirrhosis (2.65;1.95 to 3.59) was associated with an increased risk of COVID-19 death. Individuals with cancer of the blood or bone marrow, chronic kidney disease, cystic fibrosis, pulmonary hypotension or fibrosis, or rheumatoid arthritis or systemic lupus erythematosus had a significantly higher risk of COVID-19 death relative to other causes of death compared with individuals who did not have diagnoses. Policy makers should continue to priorities vulnerable groups for subsequent COVID-19 booster doses to minimise the risk of COVID-19 death. Ward et al. utilise electronic health records to identify groups of adults (who had received a second booster dose of a COVID-19 vaccine) at elevated risk of COVID-19 death.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-023-44276-x