Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity

The circadian clock regulator Bmal1 modulates tumorigenesis, but its reported effects are inconsistent. Here, we show that Bmal1 has a context-dependent role in mouse melanoma tumor growth. Loss of Bmal1 in YUMM2.1 or B16-F10 melanoma cells eliminates clock function and diminishes hypoxic gene expre...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 633 - 19
Main Authors:	Zhang, Xue, Pant, Shishir M., Ritch, Cecily C., Tang, Hsin-Yao, Shao, Hongguang, Dweep, Harsh, Gong, Yao-Yu, Brooks, Rebekah, Brafford, Patricia, Wolpaw, Adam J., Lee, Yool, Weeraratna, Ashani, Sehgal, Amita, Herlyn, Meenhard, Kossenkov, Andrew, Speicher, David, Sorger, Peter K., Santagata, Sandro, Dang, Chi V.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 20.01.2024 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/106 13/109 13/21 13/31 13/44 13/89 13/95 14/19 14/63 38/39 45/77 45/91 49/15 49/88 49/90 631/67/1813/1634 631/67/580 631/80/105 64/60 82/29 82/58 Animals ARNTL Transcription Factors - genetics ARNTL Transcription Factors - metabolism Biological clocks BMAL1 protein Carcinogenesis - genetics Circadian Clocks - genetics Circadian rhythm Circadian Rhythm - genetics Circadian rhythms Cytoskeleton Ectopic expression Gene expression Humanities and Social Sciences Humans Hypoxia Immunity Melanoma Melanoma - genetics Mice multidisciplinary Myosin Science Science (multidisciplinary) Transcription factors Tumorigenesis Tumorigenicity Tumors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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