White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control

Cognitive control modulates other cognitive functions to achieve internal goals and is important for adaptive behavior. Cognitive control is enabled by the neural computations distributed over cortical and subcortical areas. However, due to technical challenges in recording neural activity from the...

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Vydáno v:Nature communications Ročník 14; číslo 1; s. 1740 - 12
Hlavní autoři: Jiang, Jiefeng, Bruss, Joel, Lee, Woo-Tek, Tranel, Daniel, Boes, Aaron D.
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 29.03.2023
Nature Publishing Group
Nature Portfolio
Témata:
59/57
631/378/2649
631/378/2649/2150
631/477/2811
Adaptive control
Anatomy
Behavior
Brain research
Cognition
Cognitive ability
Humanities and Social Sciences
Humans
Hypotheses
Investigations
Lesions
Machine learning
Magnetic Resonance Imaging
multidisciplinary
Neural networks
Neuropsychology
Neurosciences
Science
Science (multidisciplinary)
Substantia alba
Validity
White Matter - diagnostic imaging
White Matter - pathology
ISSN:2041-1723, 2041-1723
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Shrnutí:Cognitive control modulates other cognitive functions to achieve internal goals and is important for adaptive behavior. Cognitive control is enabled by the neural computations distributed over cortical and subcortical areas. However, due to technical challenges in recording neural activity from the white matter, little is known about the anatomy of white matter tracts that coordinate the distributed neural computations that support cognitive control. Here, we leverage a large sample of human patients with focal brain lesions (n = 643) and investigate how lesion location and connectivity profiles account for variance in cognitive control performance. We find that lesions in white matter connecting left frontoparietal regions of the multiple demand network reliably predict deficits in cognitive control performance. These findings advance our understanding of the white matter correlates of cognitive control and provide an approach for incorporating network disconnection to predict deficits following lesions. The anatomy of white matter tracts which coordinate the computations of cognitive control are not well understood. Here, the authors show that lesions in white matter connecting left frontoparietal regions are associated with deficits in cognitive control performance.
Bibliografie:ObjectType-Article-1
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-023-37330-1