Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease for which better therapies are urgently needed. Fibroblasts and macrophages are heterogeneous cell populations able to enhance metastasis, but the role of a macrophage-fibroblast crosstalk in regulating their pro-metastatic funct...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 3593 - 22
Main Authors:	Raymant, Meirion, Astuti, Yuliana, Alvaro-Espinosa, Laura, Green, Daniel, Quaranta, Valeria, Bellomo, Gaia, Glenn, Mark, Chandran-Gorner, Vatshala, Palmer, Daniel H., Halloran, Christopher, Ghaneh, Paula, Henderson, Neil C., Morton, Jennifer P., Valiente, Manuel, Mielgo, Ainhoa, Schmid, Michael C.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 27.04.2024 Nature Publishing Group Nature Portfolio
Subjects:	13/106 13/31 13/51 14 14/63 38/91 631/67/322 631/67/327 64 64/60 692/4028/67/1504/1713 Adenocarcinoma Animals Cancer Cancer-Associated Fibroblasts - metabolism Cancer-Associated Fibroblasts - pathology Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - immunology Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell Line, Tumor Cytotoxicity Female Fibroblasts Fibroblasts - metabolism Fibroblasts - pathology Heterogeneity Humanities and Social Sciences Humans Immune response Immune system Immunoregulation Inflammation Janus Kinases - metabolism Leukemia Leukemia inhibitory factor Liver Liver Neoplasms - genetics Liver Neoplasms - immunology Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms - secondary Lymphocytes Lymphocytes T Macrophages Macrophages - immunology Macrophages - metabolism Male Metastases Metastasis Mice Mice, Inbred C57BL multidisciplinary Osteopontin Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - immunology Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Phenotypes Populations Science Science (multidisciplinary) Signal Transduction Stat3 protein STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Tumor microenvironment Tumors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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