Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk

Lung cancer remains the leading cause of cancer mortality, despite declining smoking rates. Previous lung cancer GWAS have identified numerous loci, but separating the genetic risks of lung cancer and smoking behavioral susceptibility remains challenging. Here, we perform multi-ancestry GWAS meta-an...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 8629 - 13
Main Authors:	Gorman, Bryan R., Ji, Sun-Gou, Francis, Michael, Sendamarai, Anoop K., Shi, Yunling, Devineni, Poornima, Saxena, Uma, Partan, Elizabeth, DeVito, Andrea K., Byun, Jinyoung, Han, Younghun, Xiao, Xiangjun, Sin, Don D., Timens, Wim, Moser, Jennifer, Muralidhar, Sumitra, Ramoni, Rachel, Hung, Rayjean J., McKay, James D., Bossé, Yohan, Sun, Ryan, Amos, Christopher I., Pyarajan, Saiju
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 04.10.2024 Nature Publishing Group Nature Portfolio
Subjects:	45/43 631/208/205/2138 631/208/68 692/699/67/1612 Adenocarcinoma Adenocarcinoma of Lung - genetics Aged Carcinoma, Squamous Cell - genetics Case-Control Studies Chromosome 19 Cigarettes Ethnicity - genetics Female Genetic analysis Genetic Loci Genetic Predisposition to Disease Genetic Risk Score Genome-Wide Association Study Health risks Humanities and Social Sciences Humans Lung cancer Lung carcinoma Lung diseases Lung Neoplasms - genetics Lung Neoplasms - mortality Male Meta-analysis Middle Aged Mortality multidisciplinary Neoplasms Performance prediction Pleiotropy Polygenic inheritance Polymorphism, Single Nucleotide Predictive control Risk Factors Science Science (multidisciplinary) Smoking Smoking - genetics Squamous cell carcinoma White
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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