Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer

The PEAK family of pseudokinases, comprising PEAK1-3, play oncogenic roles in several poor prognosis human cancers, including triple negative breast cancer (TNBC). However, therapeutic targeting of pseudokinases is challenging due to their lack of catalytic activity. To address this, we screen for P...

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Veröffentlicht in:	Nature communications Jg. 16; H. 1; S. 1871 - 19
Hauptverfasser:	Yang, Xue, Ma, Xiuquan, Zhao, Tianyue, Croucher, David R., Nguyen, Elizabeth V., Clark, Kimberley C., Hu, Changyuan, Latham, Sharissa L., Bayly-Jones, Charles, Nguyen, Bao V., Budnar, Srikanth, Shin, Sung-Young, Nguyen, Lan K., Cotton, Thomas R., Chüeh, Anderly C., Lim Kam Sian, Terry C. C., Stratton, Margaret M., Ellisdon, Andrew M., Daly, Roger J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 22.02.2025 Nature Publishing Group Nature Portfolio
Schlagworte:	59 59/5 631/45/275 631/67/1347 631/67/395 631/80/86 82/58 82/80 96 96/1 96/106 96/95 Ablation Animals Breast cancer Ca2+/calmodulin-dependent protein kinase Calcium Calcium ions Calcium Signaling Calcium signalling Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Calmodulin Catalytic activity Cell activation Cell Line, Tumor Cell Movement - drug effects Female Humanities and Social Sciences Humans Kinases Metastases Metastasis Mice Mice, Nude multidisciplinary Phospholipase C gamma - metabolism Phosphorylation Prognosis Protein Kinase Inhibitors - pharmacology Proteins Science Science (multidisciplinary) Signal Transduction Therapeutic targets Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Tyrosine Xenograft Model Antitumor Assays Xenografts Xenotransplantation
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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