Comparison of uridine and N1-methylpseudouridine mRNA platforms in development of an Andes virus vaccine

The rodent-borne Andes virus (ANDV) causes a severe disease in humans. We developed an ANDV mRNA vaccine based on the M segment of the viral genome, either with regular uridine (U-mRNA) or N1-methylpseudouridine (m1Ψ-mRNA). Female mice immunized by m1Ψ-mRNA developed slightly greater germinal center...

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Veröffentlicht in:	Nature communications Jg. 15; H. 1; S. 6421 - 18
Hauptverfasser:	Kuzmin, Ivan V., Soto Acosta, Ruben, Pruitt, Layne, Wasdin, Perry T., Kedarinath, Kritika, Hernandez, Keziah R., Gonzales, Kristyn A., Hill, Kharighan, Weidner, Nicole G., Mire, Chad, Engdahl, Taylor B., Moon, Woohyun J., Popov, Vsevolod, Crowe, James E., Georgiev, Ivelin S., Garcia-Blanco, Mariano A., Abbott, Robert K., Bukreyev, Alexander
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 30.07.2024 Nature Publishing Group Nature Portfolio
Schlagworte:	13 13/1 13/106 13/109 13/21 13/31 13/51 13/62 38 38/23 631/250/2152/2153/1982 631/326/590/2293 631/326/596 Animals Antibodies Antibodies, Neutralizing - immunology Antibodies, Viral - immunology B-Lymphocytes - immunology Cell activation Cricetinae Female Females Gene expression Gene sequencing Germinal Center - immunology Germinal centers Glycoproteins Hamsters Hemorrhagic Fever, American - immunology Hemorrhagic Fever, American - prevention & control Hemorrhagic Fever, American - virology Humanities and Social Sciences Humans Immune response Immune system Immunization Immunogenicity Lethal dose Lymphocytes B Mesocricetus Mice mRNA mRNA Vaccines multidisciplinary Orthohantavirus - genetics Orthohantavirus - immunology Pseudouridine - immunology RNA modification RNA, Messenger - genetics RNA, Messenger - immunology RNA, Messenger - metabolism RNA, Viral - genetics RNA, Viral - immunology Rodents Science Science (multidisciplinary) Segments Uridine Vaccine Development Vaccines Viral Vaccines - administration & dosage Viral Vaccines - immunology Viruses
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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