Overcoming adaptive resistance to anti-VEGF therapy by targeting CD5L

Antiangiogenic treatment targeting the vascular endothelial growth factor (VEGF) pathway is a powerful tool to combat tumor growth and progression; however, drug resistance frequently emerges. We identify CD5L (CD5 antigen-like precursor) as an important gene upregulated in response to antiangiogeni...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; pp. 2407 - 18
Main Authors:	LaFargue, Christopher J., Amero, Paola, Noh, Kyunghee, Mangala, Lingegowda S., Wen, Yunfei, Bayraktar, Emine, Umamaheswaran, Sujanitha, Stur, Elaine, Dasari, Santosh K., Ivan, Cristina, Pradeep, Sunila, Yoo, Wonbeak, Lu, Chunhua, Jennings, Nicholas B., Vathipadiekal, Vinod, Hu, Wei, Chelariu-Raicu, Anca, Ku, Zhiqiang, Deng, Hui, Xiong, Wei, Choi, Hyun-Jin, Hu, Min, Kiyama, Takae, Mao, Chai-An, Ali-Fehmi, Rouba, Birrer, Michael J., Liu, Jinsong, Zhang, Ningyan, Lopez-Berestein, Gabriel, de Franciscis, Vittorio, An, Zhiqiang, Sood, Anil K.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 26.04.2023 Nature Publishing Group Nature Portfolio
Subjects:	13 13/1 13/106 13/109 13/21 13/51 42 42/41 42/89 631/67 631/67/327 Angiogenesis Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Antiangiogenics Antibodies, Monoclonal - pharmacology Antigens Apoptosis Regulatory Proteins Aptamers Bevacizumab Bevacizumab - pharmacology Bevacizumab - therapeutic use Cancer CD5 antigen Cell activation Drug resistance Endothelial cells Growth factors Humanities and Social Sciences Humans Hypoxia Monoclonal antibodies multidisciplinary Neoplasms - drug therapy Neoplasms - genetics Ovarian cancer Receptors, Scavenger Resistance factors Science Science (multidisciplinary) Therapy Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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