Variational graph autoencoder for reconstructed transcriptomic data associated with NLRP3 mediated pyroptosis in periodontitis

The NLRP3 inflammasome, regulated by TLR4, plays a pivotal role in periodontitis by mediating inflammatory cytokine release and bone loss induced by Porphyromonas gingivalis . Periodontal disease creates a hypoxic environment, favoring anaerobic bacteria survival and exacerbating inflammation. The N...

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Bibliographic Details
Published in:	Scientific reports Vol. 15; no. 1; pp. 1962 - 11
Main Authors:	Yadalam, Pradeep K., Natarajan, Prabhu Manickam, Ardila, Carlos M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14.01.2025 Nature Publishing Group Nature Portfolio
Subjects:	631/114 692/308 Anaerobic bacteria Apoptosis Autoencoder Bone loss Cell death Cell survival Deep learning Gene expression Gene Expression Profiling Gum disease Humanities and Social Sciences Humans Hypoxia Inflammasome Inflammasomes Inflammasomes - genetics Inflammasomes - metabolism K means clustering multidisciplinary NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Periodontal diseases Periodontitis Periodontitis - genetics Periodontitis - metabolism Periodontitis - microbiology Periodontitis - pathology Porphyromonas gingivalis Pyroptosis Pyroptosis - genetics Science Science (multidisciplinary) TLR4 protein Toll-like receptors Transcriptome Transcriptomics Variational autoencoders Variational autoencoders Inflammasome Periodontitis K means clustering
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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