Molecular dynamics simulation on regulation of liquid–liquid phase separation of repetitive peptides

Understanding the intricate interactions governing protein and peptide behavior in liquid–liquid phase separation (LLPS) is crucial for unraveling biological functions and dysfunctions. This study employs a residue-leveled coarse-grained molecular dynamics approach to simulate the phase separation o...

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Bibliographic Details
Published in:	Scientific reports Vol. 14; no. 1; pp. 13382 - 10
Main Authors:	Yang, Xiaojun, Wang, Yanwei, Yang, Guangcan
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 11.06.2024 Nature Publishing Group Nature Portfolio
Subjects:	631/57/2266 631/57/2269 631/57/2272 Dielectric constant DNA - chemistry DNA - metabolism Electrostatic interaction Electrostatic properties GENESIS Humanities and Social Sciences Hydrophobic and Hydrophilic Interactions Hydrophobicity Liquid–liquid phase separation Molecular dynamics Molecular Dynamics Simulation multidisciplinary Peptides Peptides - chemistry Phase Separation Phase Transition Polypeptides Polyproline Salts Science Science (multidisciplinary) Temperature Temperature effects Liquid–liquid phase separation Molecular dynamics Polypeptides Hydrophobicity GENESIS Electrostatic interaction
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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