Involvement of the pro-oncogenic enzyme fatty acid synthase in the hallmarks of cancer: a promising target in anti-cancer therapies

An accelerated de novo lipogenesis (DNL) flux is a common characteristic of cancer cells required to sustain a high proliferation rate. The DNL enzyme fatty acid synthase (FASN) is overexpressed in many cancers and is pivotal for the increased production of fatty acids. There is increasing evidences...

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Bibliographic Details
Published in:	Oncogenesis (New York, NY) Vol. 12; no. 1; pp. 16 - 10
Main Authors:	Vanauberg, Dimitri, Schulz, Céline, Lefebvre, Tony
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18.03.2023 Nature Publishing Group
Subjects:	631/154/53 631/67/395 Angiogenesis Apoptosis Cancer Cancer therapies Cell activation Cell Biology Cell death Cell growth Cell proliferation Chemotherapy Enzymes ErbB-2 protein Fatty acids Fatty-acid synthase Human Genetics Immunoregulation Inflammation Internal Medicine Lipid rafts Lipogenesis Localization Lymphocytes T Macrophages Medicine Medicine & Public Health Metastases Oncology Protein biosynthesis Review Review Article Tumor microenvironment
ISSN:	2157-9024, 2157-9024
Online Access:	Get full text
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