Involvement of the pro-oncogenic enzyme fatty acid synthase in the hallmarks of cancer: a promising target in anti-cancer therapies

An accelerated de novo lipogenesis (DNL) flux is a common characteristic of cancer cells required to sustain a high proliferation rate. The DNL enzyme fatty acid synthase (FASN) is overexpressed in many cancers and is pivotal for the increased production of fatty acids. There is increasing evidences...

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Vydáno v:Oncogenesis (New York, NY) Ročník 12; číslo 1; s. 16 - 10
Hlavní autoři: Vanauberg, Dimitri, Schulz, Céline, Lefebvre, Tony
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 18.03.2023
Nature Publishing Group
Témata:
631/154/53
631/67/395
Angiogenesis
Apoptosis
Cancer
Cancer therapies
Cell activation
Cell Biology
Cell death
Cell growth
Cell proliferation
Chemotherapy
Enzymes
ErbB-2 protein
Fatty acids
Fatty-acid synthase
Human Genetics
Immunoregulation
Inflammation
Internal Medicine
Lipid rafts
Lipogenesis
Localization
Lymphocytes T
Macrophages
Medicine
Medicine & Public Health
Metastases
Oncology
Protein biosynthesis
Review
Review Article
Tumor microenvironment
ISSN:2157-9024, 2157-9024
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Shrnutí:An accelerated de novo lipogenesis (DNL) flux is a common characteristic of cancer cells required to sustain a high proliferation rate. The DNL enzyme fatty acid synthase (FASN) is overexpressed in many cancers and is pivotal for the increased production of fatty acids. There is increasing evidences of the involvement of FASN in several hallmarks of cancer linked to its ability to promote cell proliferation via membranes biosynthesis. In this review we discuss about the implication of FASN in the resistance to cell death and in the deregulation of cellular energetics by increasing nucleic acids, protein and lipid synthesis. FASN also promotes cell proliferation, cell invasion, metastasis and angiogenesis by enabling the building of lipid rafts and consequently to the localization of oncogenic receptors such as HER2 and c-Met in membrane microdomains. Finally, FASN is involved in immune escape by repressing the activation of pro-inflammatory cells and promoting the recruitment of M2 macrophages and T regulatory cells in the tumor microenvironment. Here, we provide an overview of the involvement of the pro-oncogenic enzyme in the hallmarks of cancer making FASN a promising target in anti-cancer therapy to circumvent resistance to chemotherapies.
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ISSN:2157-9024
2157-9024
DOI:10.1038/s41389-023-00460-8