Motor cortex and spinal cord neuromodulation promote corticospinal tract axonal outgrowth and motor recovery after cervical contusion spinal cord injury

Cervical injuries are the most common form of SCI. In this study, we used a neuromodulatory approach to promote skilled movement recovery and repair of the corticospinal tract (CST) after a moderately severe C4 midline contusion in adult rats. We used bilateral epidural intermittent theta burst (iTB...

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Bibliographic Details
Published in:	Experimental neurology Vol. 297; pp. 179 - 189
Main Authors:	Zareen, N., Shinozaki, M., Ryan, D., Alexander, H., Amer, A., Truong, D.Q., Khadka, N., Sarkar, A., Naeem, S., Bikson, M., Martin, J.H.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.11.2017
Subjects:	Animals Axons - physiology Cervical contusion Cervical Vertebrae Contusions - physiopathology Contusions - therapy Corticospinal tract Electromyography - methods FEM modeling Female Intermittent theta burst stimulation Motor cortex Motor Cortex - physiology Pyramidal Tracts - physiology Rat Rats Rats, Sprague-Dawley Recovery of Function - physiology Skilled limb movement Spinal Cord - physiology Spinal Cord Injuries - physiopathology Spinal Cord Injuries - therapy Spinal Cord Stimulation - methods Trans-spinal direct current stimulation Skilled limb movement Rat Cervical contusion Motor cortex Intermittent theta burst stimulation Corticospinal tract Trans-spinal direct current stimulation FEM modeling
ISSN:	0014-4886, 1090-2430, 1090-2430
Online Access:	Get full text
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