The receptor VLDLR binds Eastern Equine Encephalitis virus through multiple distinct modes

Eastern Equine Encephalitis virus (EEEV) is an alphavirus that can cause severe diseases in infected humans. The very low-density lipoprotein receptor (VLDLR) was recently identified as a receptor of EEEV. Herein, we performed cryo-electron microscopy structural and biochemistry studies on the speci...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 6866 - 15
Main Authors:	Cao, Duanfang, Ma, Bingting, Cao, Ziyi, Xu, Xiaoyu, Zhang, Xinzheng, Xiang, Ye
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 10.08.2024 Nature Publishing Group Nature Portfolio
Subjects:	101/28 631/326/596/1282 631/535/1258/1259 82/1 82/16 82/80 82/83 Animals Binding Binding Sites Cell adhesion Cryoelectron Microscopy Density Eastern equine encephalitis Electron microscopy Encephalitis Encephalitis Virus, Eastern Equine - genetics Encephalitis Virus, Eastern Equine - metabolism Gene sequencing HEK293 Cells Humanities and Social Sciences Humans Low density lipoprotein receptors Models, Molecular multidisciplinary Mutation Protein Binding Receptor density Receptors Receptors, LDL - genetics Receptors, LDL - metabolism Receptors, Virus - metabolism Science Science (multidisciplinary) Single-nucleotide polymorphism Virus Attachment Viruses
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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