NF-κB in biology and targeted therapy: new insights and translational implications

NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses. However, with extensive and in-depth investigations, researchers have discovered that its role can be expanded to a variety of signaling mechan...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Signal transduction and targeted therapy Ročník 9; číslo 1; s. 53 - 37
Hlavní autori:	Guo, Qing, Jin, Yizi, Chen, Xinyu, Ye, Xiaomin, Shen, Xin, Lin, Mingxi, Zeng, Cheng, Zhou, Teng, Zhang, Jian
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 04.03.2024 Nature Publishing Group
Predmet:	1-Phosphatidylinositol 3-kinase 631/67 692/4028 AKT protein Autoimmune diseases Cancer Research Cardiovascular diseases Cell Biology COVID-19 Humans Immunoregulation Immunotherapy Internal Medicine MAP kinase Medical research Medicine Medicine & Public Health Metabolic disorders Monoclonal antibodies Neurological diseases NF-kappa B - genetics NF-κB protein Non-coding RNA Nuclear transport Oncology Pathology Phosphatidylinositol 3-Kinases Proteasome inhibitors Proteasomes Review Review Article Signal transduction Signal Transduction - genetics Transforming growth factor-b Tumor microenvironment Wnt protein
ISSN:	2059-3635, 2095-9907, 2059-3635
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Popis
Shrnutí:	NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses. However, with extensive and in-depth investigations, researchers have discovered that its role can be expanded to a variety of signaling mechanisms, biological processes, human diseases, and treatment options. In this review, we first scrutinize the research process of NF-κB signaling, and summarize the composition, activation, and regulatory mechanism of NF-κB signaling. We investigate the interaction of NF-κB signaling with other important pathways, including PI3K/AKT, MAPK, JAK-STAT, TGF-β, Wnt, Notch, Hedgehog, and TLR signaling. The physiological and pathological states of NF-κB signaling, as well as its intricate involvement in inflammation, immune regulation, and tumor microenvironment, are also explicated. Additionally, we illustrate how NF-κB signaling is involved in a variety of human diseases, including cancers, inflammatory and autoimmune diseases, cardiovascular diseases, metabolic diseases, neurological diseases, and COVID-19. Further, we discuss the therapeutic approaches targeting NF-κB signaling, including IKK inhibitors, monoclonal antibodies, proteasome inhibitors, nuclear translocation inhibitors, DNA binding inhibitors, TKIs, non-coding RNAs, immunotherapy, and CAR-T. Finally, we provide an outlook for research in the field of NF-κB signaling. We hope to present a stereoscopic, comprehensive NF-κB signaling that will inform future research and clinical practice.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	2059-3635 2095-9907 2059-3635
DOI:	10.1038/s41392-024-01757-9