Effects of cadherin mediated contact normalization on oncogenic Src kinase mediated gene expression and protein phosphorylation

Nontransformed cells form heterotypic cadherin junctions with adjacent transformed cells to inhibit tumor cell growth and motility. Transformed cells must override this form of growth control, called “contact normalization”, to invade and metastasize during cancer progression. Heterocellular cadheri...

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Bibliographic Details
Published in:	Scientific reports Vol. 14; no. 1; pp. 23942 - 16
Main Authors:	Nicoletto, Rachel E., Holdcraft, Cayla J., Yin, Ariel C., Retzbach, Edward P., Sheehan, Stephanie A., Greenspan, Amanda A., Laugier, Christopher M., Trama, Jason, Zhao, Caifeng, Zheng, Haiyan, Goldberg, Gary S.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 13.10.2024 Nature Publishing Group Nature Portfolio
Subjects:	631/67/327 631/80/304 Animals beta Catenin - genetics beta Catenin - metabolism Cadherins Cadherins - genetics Cadherins - metabolism Cell activation Cell culture Cell transformation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Contact normalization Gene expression Genetic transformation Humanities and Social Sciences Kinases Mice multidisciplinary PDPN Phosphorylation Podoplanin Science Science (multidisciplinary) Src kinase Src protein src-Family Kinases - genetics src-Family Kinases - metabolism Transformed cells Tumors Tyrosine Wnt protein Wnt Signaling Pathway β-Catenin Src kinase Contact normalization Cell transformation PDPN Podoplanin
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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