A simple method for developing lysine targeted covalent protein reagents

Peptide-based covalent probes can target shallow protein surfaces not typically addressable using small molecules, yet there is a need for versatile approaches to convert native peptide sequences into covalent binders that can target a broad range of residues. Here we report protein-based thio-metha...

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Veröffentlicht in:	Nature communications Jg. 14; H. 1; S. 7933 - 16
Hauptverfasser:	Gabizon, Ronen, Tivon, Barr, Reddi, Rambabu N., van den Oetelaar, Maxime C. M., Amartely, Hadar, Cossar, Peter J., Ottmann, Christian, London, Nir
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.12.2023 Nature Publishing Group Nature Portfolio
Schlagworte:	14-3-3 protein 631/92/2783 631/92/611 631/92/96 82/16 82/29 82/58 82/80 82/83 Binders Binding Colicin E9 Covalence Cysteine Cysteine - chemistry Deoxyribonuclease Esters Humanities and Social Sciences Indicators and Reagents Lysates Lysine Lysine - metabolism Methacrylates multidisciplinary Peptides Peptides - chemistry Proteins Reagents Residues Science Science (multidisciplinary) Thermal stability
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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