A single-dose intranasal live-attenuated codon deoptimized vaccine provides broad protection against SARS-CoV-2 and its variants

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) continues its significant health and economic impact globally. Despite the success of spike-protein vaccines in preventing severe disease, long-lasting protection against emerging variants and the prevention of breakthrough infec...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 7225 - 19
Main Authors:	Liu, Xiang, Ng, Wern Hann, Zusinaite, Eva, Freitas, Joseph, Taylor, Adam, Yerragunta, Venugopal, Aavula, Shukra Madhaha, Gorriparthi, Sambaiah, Ponsekaran, Santhakumar, Bonda, Rama Lakshmi, Mani, Priyanka, Nimmagadda, Sridevi V., Wang, Sainan, Lello, Laura Sandra, Zaid, Ali, Dua, Ujjwal, Taft-Benz, Sharon A., Anderson, Elizabeth, Baxter, Victoria K., Sarkar, Sanjay, Ling, Zheng L., Ashhurst, Thomas M., Cheng, Samuel M. S., Pattnaik, Priyabrata, Kanakasapapathy, Anand Kumar, Baric, Ralph S., Burt, Felicity J., Peiris, Malik, Heise, Mark T., King, Nicholas J. C., Merits, Andres, Lingala, Rajendra, Mahalingam, Suresh
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 26.08.2024 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/106 13/109 13/21 13/31 13/44 14/63 38/44 38/77 38/88 38/91 631/1647/334/1874/1535 631/1647/334/1874/1625 631/1647/334/1874/345 631/326/590/1867 631/326/596/4130 64/110 64/60 Administration, Intranasal Animal models Animals Antibodies Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Attenuation Chlorocebus aethiops Codon Coronaviruses COVID-19 COVID-19 - immunology COVID-19 - prevention & control COVID-19 - virology COVID-19 Vaccines - administration & dosage COVID-19 Vaccines - immunology Cricetinae Disease transmission Economic impact Female Hamsters Humanities and Social Sciences Humans Immunity Immunization Lymphocytes T Male Mice multidisciplinary Proteins SARS-CoV-2 - genetics SARS-CoV-2 - immunology Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology T-Lymphocytes - immunology Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology Viral diseases
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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