Six-year trajectories and associated factors of positive and negative symptoms in schizophrenia patients, siblings, and controls: Genetic Risk and Outcome of Psychosis (GROUP) study
Positive and negative symptoms are prominent but heterogeneous characteristics of schizophrenia spectrum disorder (SSD). Within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) longitudinal cohort study, we aimed to distinguish and identify the genetic and non-genetics predictors o...
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| Published in: | Scientific reports Vol. 13; no. 1; pp. 9391 - 11 |
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| Abstract | Positive and negative symptoms are prominent but heterogeneous characteristics of schizophrenia spectrum disorder (SSD). Within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) longitudinal cohort study, we aimed to distinguish and identify the genetic and non-genetics predictors of homogenous subgroups of the long-term course of positive and negative symptoms in SSD patients (n = 1119) and their unaffected siblings (n = 1059) in comparison to controls (n = 586). Data were collected at baseline, and after 3- and 6-year follow-ups. Group-based trajectory modeling was applied to identify latent subgroups using positive and negative symptoms or schizotypy scores. A multinomial random-effects logistic regression model was used to identify predictors of latent subgroups. Patients had decreasing, increasing, and relapsing symptoms course. Unaffected siblings and healthy controls had three to four subgroups characterized by stable, decreasing, or increasing schizotypy. PRS
SCZ
did not predict the latent subgroups. Baseline symptoms severity in patients, premorbid adjustment, depressive symptoms, and quality of life in siblings predicted long-term trajectories while were nonsignificant in controls. In conclusion, up to four homogenous latent subgroups of symptom course can be distinguished within patients, siblings, and controls, while non-genetic factors are the main factors associated with the latent subgroups. |
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| AbstractList | Positive and negative symptoms are prominent but heterogeneous characteristics of schizophrenia spectrum disorder (SSD). Within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) longitudinal cohort study, we aimed to distinguish and identify the genetic and non-genetics predictors of homogenous subgroups of the long-term course of positive and negative symptoms in SSD patients (n = 1119) and their unaffected siblings (n = 1059) in comparison to controls (n = 586). Data were collected at baseline, and after 3- and 6-year follow-ups. Group-based trajectory modeling was applied to identify latent subgroups using positive and negative symptoms or schizotypy scores. A multinomial random-effects logistic regression model was used to identify predictors of latent subgroups. Patients had decreasing, increasing, and relapsing symptoms course. Unaffected siblings and healthy controls had three to four subgroups characterized by stable, decreasing, or increasing schizotypy. PRSSCZ did not predict the latent subgroups. Baseline symptoms severity in patients, premorbid adjustment, depressive symptoms, and quality of life in siblings predicted long-term trajectories while were nonsignificant in controls. In conclusion, up to four homogenous latent subgroups of symptom course can be distinguished within patients, siblings, and controls, while non-genetic factors are the main factors associated with the latent subgroups.Positive and negative symptoms are prominent but heterogeneous characteristics of schizophrenia spectrum disorder (SSD). Within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) longitudinal cohort study, we aimed to distinguish and identify the genetic and non-genetics predictors of homogenous subgroups of the long-term course of positive and negative symptoms in SSD patients (n = 1119) and their unaffected siblings (n = 1059) in comparison to controls (n = 586). Data were collected at baseline, and after 3- and 6-year follow-ups. Group-based trajectory modeling was applied to identify latent subgroups using positive and negative symptoms or schizotypy scores. A multinomial random-effects logistic regression model was used to identify predictors of latent subgroups. Patients had decreasing, increasing, and relapsing symptoms course. Unaffected siblings and healthy controls had three to four subgroups characterized by stable, decreasing, or increasing schizotypy. PRSSCZ did not predict the latent subgroups. Baseline symptoms severity in patients, premorbid adjustment, depressive symptoms, and quality of life in siblings predicted long-term trajectories while were nonsignificant in controls. In conclusion, up to four homogenous latent subgroups of symptom course can be distinguished within patients, siblings, and controls, while non-genetic factors are the main factors associated with the latent subgroups. Positive and negative symptoms are prominent but heterogeneous characteristics of schizophrenia spectrum disorder (SSD). Within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) longitudinal cohort study, we aimed to distinguish and identify the genetic and non-genetics predictors of homogenous subgroups of the long-term course of positive and negative symptoms in SSD patients (n = 1119) and their unaffected siblings (n = 1059) in comparison to controls (n = 586). Data were collected at baseline, and after 3- and 6-year follow-ups. Group-based trajectory modeling was applied to identify latent subgroups using positive and negative symptoms or schizotypy scores. A multinomial random-effects logistic regression model was used to identify predictors of latent subgroups. Patients had decreasing, increasing, and relapsing symptoms course. Unaffected siblings and healthy controls had three to four subgroups characterized by stable, decreasing, or increasing schizotypy. PRSSCZ did not predict the latent subgroups. Baseline symptoms severity in patients, premorbid adjustment, depressive symptoms, and quality of life in siblings predicted long-term trajectories while were nonsignificant in controls. In conclusion, up to four homogenous latent subgroups of symptom course can be distinguished within patients, siblings, and controls, while non-genetic factors are the main factors associated with the latent subgroups. Positive and negative symptoms are prominent but heterogeneous characteristics of schizophrenia spectrum disorder (SSD). Within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) longitudinal cohort study, we aimed to distinguish and identify the genetic and non-genetics predictors of homogenous subgroups of the long-term course of positive and negative symptoms in SSD patients (n = 1119) and their unaffected siblings (n = 1059) in comparison to controls (n = 586). Data were collected at baseline, and after 3- and 6-year follow-ups. Group-based trajectory modeling was applied to identify latent subgroups using positive and negative symptoms or schizotypy scores. A multinomial random-effects logistic regression model was used to identify predictors of latent subgroups. Patients had decreasing, increasing, and relapsing symptoms course. Unaffected siblings and healthy controls had three to four subgroups characterized by stable, decreasing, or increasing schizotypy. PRS SCZ did not predict the latent subgroups. Baseline symptoms severity in patients, premorbid adjustment, depressive symptoms, and quality of life in siblings predicted long-term trajectories while were nonsignificant in controls. In conclusion, up to four homogenous latent subgroups of symptom course can be distinguished within patients, siblings, and controls, while non-genetic factors are the main factors associated with the latent subgroups. Abstract Positive and negative symptoms are prominent but heterogeneous characteristics of schizophrenia spectrum disorder (SSD). Within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) longitudinal cohort study, we aimed to distinguish and identify the genetic and non-genetics predictors of homogenous subgroups of the long-term course of positive and negative symptoms in SSD patients (n = 1119) and their unaffected siblings (n = 1059) in comparison to controls (n = 586). Data were collected at baseline, and after 3- and 6-year follow-ups. Group-based trajectory modeling was applied to identify latent subgroups using positive and negative symptoms or schizotypy scores. A multinomial random-effects logistic regression model was used to identify predictors of latent subgroups. Patients had decreasing, increasing, and relapsing symptoms course. Unaffected siblings and healthy controls had three to four subgroups characterized by stable, decreasing, or increasing schizotypy. PRSSCZ did not predict the latent subgroups. Baseline symptoms severity in patients, premorbid adjustment, depressive symptoms, and quality of life in siblings predicted long-term trajectories while were nonsignificant in controls. In conclusion, up to four homogenous latent subgroups of symptom course can be distinguished within patients, siblings, and controls, while non-genetic factors are the main factors associated with the latent subgroups. Positive and negative symptoms are prominent but heterogeneous characteristics of schizophrenia spectrum disorder (SSD). Within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) longitudinal cohort study, we aimed to distinguish and identify the genetic and non-genetics predictors of homogenous subgroups of the long-term course of positive and negative symptoms in SSD patients (n = 1119) and their unaffected siblings (n = 1059) in comparison to controls (n = 586). Data were collected at baseline, and after 3- and 6-year follow-ups. Group-based trajectory modeling was applied to identify latent subgroups using positive and negative symptoms or schizotypy scores. A multinomial random-effects logistic regression model was used to identify predictors of latent subgroups. Patients had decreasing, increasing, and relapsing symptoms course. Unaffected siblings and healthy controls had three to four subgroups characterized by stable, decreasing, or increasing schizotypy. PRS did not predict the latent subgroups. Baseline symptoms severity in patients, premorbid adjustment, depressive symptoms, and quality of life in siblings predicted long-term trajectories while were nonsignificant in controls. In conclusion, up to four homogenous latent subgroups of symptom course can be distinguished within patients, siblings, and controls, while non-genetic factors are the main factors associated with the latent subgroups. |
| ArticleNumber | 9391 |
| Author | Habtewold, Tesfa Dejenie Islam, Md Atiqul Alizadeh, Behrooz Z. Bruggeman, Richard Sandhu, Amrit Kaur Tiles-Sar, Natalia Liemburg, Edith J. Boezen, H. Marike |
| Author_xml | – sequence: 1 givenname: Tesfa Dejenie surname: Habtewold fullname: Habtewold, Tesfa Dejenie email: t.d.habtewold@umcg.nl organization: Department of Epidemiology, University Medical Center Groningen, University of Groningen, Rob Giel Research Center, University Medical Center Groningen, University Center for Psychiatry, University of Groningen – sequence: 2 givenname: Natalia surname: Tiles-Sar fullname: Tiles-Sar, Natalia organization: Department of Epidemiology, University Medical Center Groningen, University of Groningen, Rob Giel Research Center, University Medical Center Groningen, University Center for Psychiatry, University of Groningen – sequence: 3 givenname: Edith J. surname: Liemburg fullname: Liemburg, Edith J. organization: Rob Giel Research Center, University Medical Center Groningen, University Center for Psychiatry, University of Groningen – sequence: 4 givenname: Amrit Kaur surname: Sandhu fullname: Sandhu, Amrit Kaur organization: Department of Epidemiology, University Medical Center Groningen, University of Groningen – sequence: 5 givenname: Md Atiqul surname: Islam fullname: Islam, Md Atiqul organization: Department of Statistics, Jagannath University – sequence: 6 givenname: H. Marike surname: Boezen fullname: Boezen, H. Marike organization: Department of Epidemiology, University Medical Center Groningen, University of Groningen – sequence: 8 givenname: Richard surname: Bruggeman fullname: Bruggeman, Richard organization: Rob Giel Research Center, University Medical Center Groningen, University Center for Psychiatry, University of Groningen, Department of Clinical and Developmental Neuropsychology, Faculty of Behavioral and Social Sciences, University of Groningen – sequence: 9 givenname: Behrooz Z. surname: Alizadeh fullname: Alizadeh, Behrooz Z. email: b.z.alizadeh@umcg.nl organization: Department of Epidemiology, University Medical Center Groningen, University of Groningen, Rob Giel Research Center, University Medical Center Groningen, University Center for Psychiatry, University of Groningen |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37296301$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1093_schbul_sbad172 crossref_primary_10_1093_schbul_sbaf045 crossref_primary_10_3390_diseases13030066 crossref_primary_10_2196_53043 crossref_primary_10_1007_s00115_024_01790_7 crossref_primary_10_4103_NRR_NRR_D_24_01375 crossref_primary_10_1192_j_eurpsy_2023_2477 crossref_primary_10_3390_brainsci15050499 |
| Cites_doi | 10.1001/archpsyc.1992.01820080023004 10.1086/519795 10.1016/S2215-0366(18)30050-6 10.1016/j.schres.2011.03.015 10.1093/schbul/sbn041 10.1016/j.schres.2012.01.031 10.1002/sim.1522 10.1111/j.1600-0447.2005.00741.x 10.1016/j.scog.2018.01.001 10.1093/oxfordjournals.schbul.a033482 10.1017/S0033291701005141 10.1176/appi.books.9780890425596 10.1001/jamapsychiatry.2020.4614 10.1016/S0920-9964(01)00350-4 10.1016/0920-9964(90)90005-R 10.1093/schbul/15.4.559 10.1186/s12888-016-1006-3 10.1002/gepi.20486 10.1016/j.schres.2016.04.017 10.1038/ng.3656 10.1016/j.schres.2020.05.020 10.1371/journal.pone.0037852 10.1001/jamapsychiatry.2015.3058 10.1093/schbul/8.3.470 10.1192/bjp.157.6.853 10.1001/jamapsychiatry.2017.4607 10.1017/S0033291798006667 10.1038/s41586-022-04434-5 10.1176/appi.ajp.2007.07010043 10.1038/s41398-019-0612-5 10.1192/j.eurpsy.2021.11 10.1016/j.schres.2016.11.039 10.1016/j.neubiorev.2009.09.004 10.1176/appi.ajp.2012.12020218 10.1016/j.schres.2004.09.007 10.1016/j.gde.2011.02.003 10.1093/schbul/13.2.261 10.1016/j.schres.2015.07.021 10.1177/0049124101029003005 10.1016/j.schres.2017.10.037 10.1038/s41398-020-00919-x 10.1002/mpr.1352 10.1371/journal.pone.0187141 10.1016/j.wpsyc.2012.05.004 10.1177/1099800417715907 10.1002/wps.20700 10.1186/1471-244X-13-320 10.1016/j.euroneuro.2020.03.010 10.1016/j.schres.2018.08.018 10.1016/j.schres.2017.06.024 10.1038/s41398-018-0204-9 10.1016/S0033-3182(95)71666-8 10.1192/j.eurpsy.2021.13 10.1176/appi.ajp.2007.07010042 10.1002/wps.20167 |
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| References | MucciAFactors associated with real-life functioning in persons with schizophrenia in a 4-year follow-up study of the Italian network for research on psychosesJAMA Psychiatry2021785505593356607110.1001/jamapsychiatry.2020.4614 KorverNQueePJBoosHBMSimonsCJPde HaanLGenetic risk and outcome of psychosis (GROUP), a multi site longitudinal cohort study focused on gene-environment interaction: Objectives, sample characteristics, recruitment and assessment methodsInt. J. Methods Psychiatr. Res.20122120522122419500687838310.1002/mpr.1352 SenguptaSMMacDonaldKFathalliFPolygenic risk score associated with specific symptom dimensions in first-episode psychosisSchizophr. Res.20171841161212791628710.1016/j.schres.2016.11.039 KendlerKSLiebermanJAWalshDThe structured interview for schizotypy (SIS): A preliminary reportSchizophr. Bull.1989155595711:STN:280:DyaK3c7mtFyqtQ%3D%3D262343810.1093/schbul/15.4.559 American Psychiatric AssociationDiagnostic and Statistical Manual of Mental Disorders: DSM-52013American Psychiatric Publishing10.1176/appi.books.9780890425596 XavierRMDunganJRKeefeRSEVorderstrasseAPolygenic signal for symptom dimensions and cognitive performance in patients with chronic schizophreniaSchizophr. Res. Cogn.201812111929552508585227910.1016/j.scog.2018.01.001 ChenLJohnstonJAKinonBJThe longitudinal interplay between negative and positive symptom trajectories in patients under antipsychotic treatment: A post hoc analysis of data from a randomized, 1-year pragmatic trialBMC Psychiatry20131311010.1186/1471-244X-13-320 MorrisAPLindgrenCMZegginiEA powerful approach to sub-phenotype analysis in population-based genetic association studiesGenet. Epidemiol.2010343353432003937910.1002/gepi.20486 NuechterleinKHIdentification of separable cognitive factors in schizophreniaSchizophr. Res.20047229391553140510.1016/j.schres.2004.09.007 StiekemaAPIslamMALiemburgEJLong-term course of negative symptom subdomains and relationship with outcome in patients with a psychotic disorderSchizophr. Res.20171931732864891510.1016/j.schres.2017.06.024 NuechterleinKHGreenMFKernRSThe MATRICS consensus cognitive battery, part 1: Test selection, reliability, and validityAm. J. Psychiatry20081652032131817201910.1176/appi.ajp.2007.07010042 World Health OrganizationDevelopment of the world health organization WHOQOL-BREF quality of life assessmentPsychol. Med.19982855155810.1017/S0033291798006667 CarràGPositive and negative symptoms in schizophrenia: A longitudinal analysis using latent variable structural equation modellingSchizophr. Res.201920458643017734410.1016/j.schres.2018.08.018 JonasKGSchizophrenia polygenic risk score and 20-year course of illness in psychotic disordersTransl. Psychiatry2019930031727878685616810.1038/s41398-019-0612-5 DerksEMInvestigation of the genetic association between quantitative measures of psychosis and schizophrenia: A polygenic risk score analysisPLoS ONE20127e378522012PLoSO...737852D1:CAS:528:DC%2BC38XpsVWrtLk%3D22761660338223410.1371/journal.pone.0037852 RasettiRWeinbergerDRIntermediate phenotypes in psychiatric disordersCurr. Opin. Genet. Dev.2011213403481:CAS:528:DC%2BC3MXmvVanu74%3D21376566313862110.1016/j.gde.2011.02.003 GalderisiSThe influence of illness-related variables, personal resources and context-related factors on real-life functioning of people with schizophreniaWorld Psychiatry20141327528725273301421906910.1002/wps.20167 AustinSFMorsOBudtz-JørgensenELong-term trajectories of positive and negative symptoms in first episode psychosis: A 10 year follow-up study in the OPUS cohortSchizophr. Res.201516884912626529910.1016/j.schres.2015.07.021 Cannon-SpoorHEPotkinSGWyattRJMeasurement of premorbid adjustment in chronic schizophreniaSchizophr. Bull.198284704841:STN:280:DyaL3s%2FktFWjsw%3D%3D713489110.1093/schbul/8.3.470 GalderisiSInterplay among psychopathologic variables, personal resources, context-related factors, and real-life functioning in individuals with schizophrenia: A network analysisJAMA Psychiatry20187539640429450447587530610.1001/jamapsychiatry.2017.4607 VollemaMGOrmelJThe reliability of the structured interview for schizotypy-revisedSchizophr. Bull.2000266196291:STN:280:DC%2BD3cvktleisA%3D%3D1099340210.1093/oxfordjournals.schbul.a033482 HarveyPDStrassnigMPredicting the severity of everyday functional disability in people with schizophrenia: Cognitive deficits, functional capacity, symptoms, and health statusWorld Psychiatry201211737922654932336337610.1016/j.wpsyc.2012.05.004 BucciPPersistent negative symptoms in recent-onset psychosis: Relationship to treatment response and psychosocial functioningEur. Neuropsychopharmacol.20203476861:CAS:528:DC%2BB3cXms1yit74%3D3229121010.1016/j.euroneuro.2020.03.010 MistrySHarrisonJSmithDEscott-PriceVZammitSThe use of polygenic risk scores to identify phenotypes associated with genetic risk of schizophrenia: Systematic reviewSchizophr. Res.2018197282912950710.1016/j.schres.2017.10.037 AndreasenNCFlaumMArndtSThe comprehensive assessment of symptoms and history (CASH)Arch. Gen. Psychiatry1992496151:STN:280:DyaK38zksVGjug%3D%3D163725110.1001/archpsyc.1992.01820080023004 AddingtonDAddingtonJSchisselBA depression rating scale for schizophrenicsSchizophr. Res.199032472511:STN:280:DyaK3M7itVCltQ%3D%3D227898610.1016/0920-9964(90)90005-R StaufferVCaseMKollack-WalkerSTrajectories of response to treatment with atypical antipsychotic medication in patients with schizophrenia pooled from 6 double-blind, randomized clinical trialsSchizophr. Res.201113011192148975410.1016/j.schres.2011.03.015 HedekerDA mixed-effects multinomial logistic regression modelStat. Med.200322143314461270460710.1002/sim.1522 JonesHJStergiakouliETanseyKEPhenotypic manifestation of genetic risk for schizophrenia during adolescence in the general populationJAMA Psychiatry20167322122826818099502474710.1001/jamapsychiatry.2015.3058 BirchwoodMSmithJCochraneRWettonSCopestakeSThe social functioning scale: The development and validation of a new scale of social adjustment for use in family intervention programmes with schizophrenic patientsBr. J. Psychiatry19901578538591:STN:280:DyaK3M7ksFKhuw%3D%3D228909410.1192/bjp.157.6.853 KernRSNuechterleinKHGreenMFThe MATRICS consensus cognitive battery, part 2: Co-norming and standardizationAm. J. Psychiatry20081652142201817201810.1176/appi.ajp.2007.07010043 StefanisNCHanssenMSmirnisNKEvidence that three dimensions of psychosis have a distribution in the general populationPsychol. Med.2002323471:STN:280:DC%2BD387jtVyhsw%3D%3D1186632710.1017/S0033291701005141 KaySRFiszbeinAOplerLAThe positive and negative syndrome scale (PANSS) for schizophreniaSchizophr. Bull.1987132612761:STN:280:DyaL2s3ptF2huw%3D%3D361651810.1093/schbul/13.2.261 GalderisiSMucciABuchananRWArangoCNegative symptoms of schizophrenia: New developments and unanswered research questionsLancet Psychiatry201856646772960273910.1016/S2215-0366(18)30050-6 AbdinEChongSAVaingankarJATrajectories of positive, negative and general psychopathology symptoms in first episode psychosis and their relationship with functioning over a 2-year follow-up periodPLoS ONE201712e018714129095875566784210.1371/journal.pone.0187141 GalderisiSThe interplay among psychopathology, personal resources, context-related factors and real-life functioning in schizophrenia: Stability in relationships after 4 years and differences in network structure between recovered and non-recovered patientsWorld Psychiatry202019819131922687695354410.1002/wps.20700 Cooke BaileyJNIgoRPGenetic risk scoresCurr. Protoc. Hum. Genet.20169119 BigdeliTPetersonRRipkeSGenome-wide association study of clinical features in the schizophrenia psychiatric genomics consortium: Confirmation of polygenic effect on negative symptomsBioRxiv201749161349 FanousAHZhouBAggenSHGenome-wide association study of clinical dimensions of schizophrenia: Polygenic effect on disorganized symptomsAm. J. Psychiatry20121691309131723212062364671210.1176/appi.ajp.2012.12020218 XavierRMVorderstrasseAGenetic basis of positive and negative symptom domains in schizophreniaBiol. Res. Nurs.2017195595752869150710.1177/1099800417715907 JonesBLNaginDSRoederKA SAS procedure based on mixture models for estimating developmental trajectoriesSociol. Methods Res.200129374393181641010.1177/0049124101029003005 GoghariVMSponheimSRMacDonaldAWIIIThe functional neuroanatomy of symptom dimensions in schizophrenia: A qualitative and quantitative review of a persistent questionNeurosci. Biobehav. Rev.2010344684861977287210.1016/j.neubiorev.2009.09.004 TrubetskoyVMapping genomic loci implicates genes and synaptic biology in schizophreniaNature20226045025082022Natur.604..502T1:CAS:528:DC%2BB38XpvVWjurw%3D35396580939246610.1038/s41586-022-04434-5 HabtewoldTDLiemburgEJIslamMAAssociation of schizophrenia polygenic risk score with data-driven cognitive subtypes: A six-year longitudinal study in patients, siblings and controlsSchizophr. Res.202010.1016/j.schres.2020.05.02032631699 VollemaMGSitskoornMMAppelsMCMKahnRSDoes the schizotypal personality questionnaire reflect the biological–genetic vulnerability to schizophrenia?Schizophr. Res.20025439451:STN:280:DC%2BD387itVahtQ%3D%3D1185397710.1016/S0920-9964(01)00350-4 CuestaMJPeraltaVCurrent psychopathological issues in psychosis: Towards a phenome-wide scanning approachSchizophr. Bull.20083458718483012263244910.1093/schbul/sbn041 GalderisiSEPA guidance on assessment of negative symptoms in schizophreniaEur. Psychiatry202164e231:STN:280:DC%2BB3snltlWruw%3D%3D33597064808020710.1192/j.eurpsy.2021.11 SolbergDKBentsenHRefsumHAndreassenOALipid profiles in schizophrenia associated with clinical traits: A five year follow-up studyBMC Psychiatry20161629927562545500042310.1186/s12888-016-1006-3 HabtewoldTDRodijkLHLiemburgEJA systematic review and narrative synthesis of data-driven studies in schizophrenia symptoms and cognitive deficitsTransl. Psychiatry20201012410.1038/s41398-020-00919-x JonesHJHeronJHammertonGInvestigating the genetic architecture of general and specific psychopathology in adolescenceTransl. Psychiatry201881111 A Mucci (36235_CR7) 2021; 78 N Korver (36235_CR34) 2012; 21 S Galderisi (36235_CR38) 2018; 5 M Konings (36235_CR45) 2006; 114 V Trubetskoy (36235_CR54) 2022; 604 PD Harvey (36235_CR3) 2012; 11 AP Stiekema (36235_CR2) 2017; 193 TD Habtewold (36235_CR44) 2020 HJ Jones (36235_CR28) 2018; 8 KG Jonas (36235_CR25) 2019; 9 RCW Hall (36235_CR51) 1995; 36 RM Xavier (36235_CR29) 2018; 12 SR Kay (36235_CR35) 1987; 13 MG Vollema (36235_CR39) 2000; 26 MJ Cuesta (36235_CR13) 2008; 34 S Mistry (36235_CR26) 2018; 197 AP Morris (36235_CR17) 2010; 34 KH Nuechterlein (36235_CR43) 2004; 72 World Health Organization (36235_CR49) 1998; 28 NC Stefanis (36235_CR46) 2002; 32 KH Nuechterlein (36235_CR42) 2008; 165 S Galderisi (36235_CR6) 2018; 75 VM Goghari (36235_CR14) 2010; 34 American Psychiatric Association (36235_CR1) 2013 S Galderisi (36235_CR5) 2020; 19 D Addington (36235_CR47) 1990; 3 E Abdin (36235_CR56) 2017; 12 S Galderisi (36235_CR36) 2021; 64 AH Fanous (36235_CR19) 2012; 169 G Carrà (36235_CR15) 2019; 204 S Das (36235_CR53) 2016; 48 RS Wallwork (36235_CR37) 2012; 137 KS Kendler (36235_CR41) 1989; 15 RS Kern (36235_CR27) 2008; 165 M Birchwood (36235_CR50) 1990; 157 P Bucci (36235_CR8) 2020; 34 S Purcell (36235_CR52) 2007; 81 B Gee (36235_CR10) 2016; 174 BL Jones (36235_CR55) 2001; 29 D Hedeker (36235_CR57) 2003; 22 DK Solberg (36235_CR22) 2016; 16 RM Xavier (36235_CR24) 2017; 19 SF Austin (36235_CR16) 2015; 168 S Galderisi (36235_CR9) 2021; 64 TD Habtewold (36235_CR23) 2020; 10 L Chen (36235_CR12) 2013; 13 MG Vollema (36235_CR40) 2002; 54 HJ Jones (36235_CR20) 2016; 73 EM Derks (36235_CR30) 2012; 7 R Rasetti (36235_CR11) 2011; 21 SM Sengupta (36235_CR18) 2017; 184 S Galderisi (36235_CR4) 2014; 13 V Stauffer (36235_CR21) 2011; 130 NC Andreasen (36235_CR33) 1992; 49 HE Cannon-Spoor (36235_CR48) 1982; 8 T Bigdeli (36235_CR32) 2017; 49 JN Cooke Bailey (36235_CR31) 2016; 91 |
| References_xml | – reference: MorrisAPLindgrenCMZegginiEA powerful approach to sub-phenotype analysis in population-based genetic association studiesGenet. Epidemiol.2010343353432003937910.1002/gepi.20486 – reference: KorverNQueePJBoosHBMSimonsCJPde HaanLGenetic risk and outcome of psychosis (GROUP), a multi site longitudinal cohort study focused on gene-environment interaction: Objectives, sample characteristics, recruitment and assessment methodsInt. J. Methods Psychiatr. Res.20122120522122419500687838310.1002/mpr.1352 – reference: BirchwoodMSmithJCochraneRWettonSCopestakeSThe social functioning scale: The development and validation of a new scale of social adjustment for use in family intervention programmes with schizophrenic patientsBr. J. Psychiatry19901578538591:STN:280:DyaK3M7ksFKhuw%3D%3D228909410.1192/bjp.157.6.853 – reference: AbdinEChongSAVaingankarJATrajectories of positive, negative and general psychopathology symptoms in first episode psychosis and their relationship with functioning over a 2-year follow-up periodPLoS ONE201712e018714129095875566784210.1371/journal.pone.0187141 – reference: JonesHJHeronJHammertonGInvestigating the genetic architecture of general and specific psychopathology in adolescenceTransl. Psychiatry2018811110.1038/s41398-018-0204-9 – reference: GalderisiSInterplay among psychopathologic variables, personal resources, context-related factors, and real-life functioning in individuals with schizophrenia: A network analysisJAMA Psychiatry20187539640429450447587530610.1001/jamapsychiatry.2017.4607 – reference: Cooke BaileyJNIgoRPGenetic risk scoresCurr. Protoc. Hum. Genet.20169119 – reference: World Health OrganizationDevelopment of the world health organization WHOQOL-BREF quality of life assessmentPsychol. Med.19982855155810.1017/S0033291798006667 – reference: KoningsMBakMHanssenMvan OsJKrabbendamLValidity and reliability of the CAPE: A self-report instrument for the measurement of psychotic experiences in the general populationActa Psychiatr. Scand.200611455611:STN:280:DC%2BD28zmtVaksg%3D%3D1677466210.1111/j.1600-0447.2005.00741.x – reference: CarràGPositive and negative symptoms in schizophrenia: A longitudinal analysis using latent variable structural equation modellingSchizophr. Res.201920458643017734410.1016/j.schres.2018.08.018 – reference: DerksEMInvestigation of the genetic association between quantitative measures of psychosis and schizophrenia: A polygenic risk score analysisPLoS ONE20127e378522012PLoSO...737852D1:CAS:528:DC%2BC38XpsVWrtLk%3D22761660338223410.1371/journal.pone.0037852 – reference: GalderisiSThe influence of illness-related variables, personal resources and context-related factors on real-life functioning of people with schizophreniaWorld Psychiatry20141327528725273301421906910.1002/wps.20167 – reference: AndreasenNCFlaumMArndtSThe comprehensive assessment of symptoms and history (CASH)Arch. Gen. Psychiatry1992496151:STN:280:DyaK38zksVGjug%3D%3D163725110.1001/archpsyc.1992.01820080023004 – reference: PurcellSNealeBTodd-BrownKPLINK: A tool set for whole-genome association and population-based linkage analysesAm. J. Hum. Genet.2007815595751:CAS:528:DC%2BD2sXhtVSqurrL17701901195083810.1086/519795 – reference: FanousAHZhouBAggenSHGenome-wide association study of clinical dimensions of schizophrenia: Polygenic effect on disorganized symptomsAm. J. Psychiatry20121691309131723212062364671210.1176/appi.ajp.2012.12020218 – reference: HallRCWGlobal assessment of functioning: A modified scalePsychosomatics1995362672751:STN:280:DyaK2MzmsFCqsA%3D%3D763831410.1016/S0033-3182(95)71666-8 – reference: GoghariVMSponheimSRMacDonaldAWIIIThe functional neuroanatomy of symptom dimensions in schizophrenia: A qualitative and quantitative review of a persistent questionNeurosci. Biobehav. Rev.2010344684861977287210.1016/j.neubiorev.2009.09.004 – reference: XavierRMVorderstrasseAGenetic basis of positive and negative symptom domains in schizophreniaBiol. Res. Nurs.2017195595752869150710.1177/1099800417715907 – reference: GalderisiSMucciABuchananRWArangoCNegative symptoms of schizophrenia: New developments and unanswered research questionsLancet Psychiatry201856646772960273910.1016/S2215-0366(18)30050-6 – reference: StaufferVCaseMKollack-WalkerSTrajectories of response to treatment with atypical antipsychotic medication in patients with schizophrenia pooled from 6 double-blind, randomized clinical trialsSchizophr. Res.201113011192148975410.1016/j.schres.2011.03.015 – reference: TrubetskoyVMapping genomic loci implicates genes and synaptic biology in schizophreniaNature20226045025082022Natur.604..502T1:CAS:528:DC%2BB38XpvVWjurw%3D35396580939246610.1038/s41586-022-04434-5 – reference: HabtewoldTDRodijkLHLiemburgEJA systematic review and narrative synthesis of data-driven studies in schizophrenia symptoms and cognitive deficitsTransl. Psychiatry20201012410.1038/s41398-020-00919-x – reference: RasettiRWeinbergerDRIntermediate phenotypes in psychiatric disordersCurr. Opin. Genet. Dev.2011213403481:CAS:528:DC%2BC3MXmvVanu74%3D21376566313862110.1016/j.gde.2011.02.003 – reference: JonesBLNaginDSRoederKA SAS procedure based on mixture models for estimating developmental trajectoriesSociol. Methods Res.200129374393181641010.1177/0049124101029003005 – reference: American Psychiatric AssociationDiagnostic and Statistical Manual of Mental Disorders: DSM-52013American Psychiatric Publishing10.1176/appi.books.9780890425596 – reference: WallworkRSFortgangRHashimotoRWeinbergerDRDickinsonDSearching for a consensus five-factor model of the positive and negative syndrome scale for schizophreniaSchizophr. Res.20121372462501:STN:280:DC%2BC38vjvFShtA%3D%3D22356801335153610.1016/j.schres.2012.01.031 – reference: ChenLJohnstonJAKinonBJThe longitudinal interplay between negative and positive symptom trajectories in patients under antipsychotic treatment: A post hoc analysis of data from a randomized, 1-year pragmatic trialBMC Psychiatry20131311010.1186/1471-244X-13-320 – reference: HabtewoldTDLiemburgEJIslamMAAssociation of schizophrenia polygenic risk score with data-driven cognitive subtypes: A six-year longitudinal study in patients, siblings and controlsSchizophr. Res.202010.1016/j.schres.2020.05.02032631699 – reference: SenguptaSMMacDonaldKFathalliFPolygenic risk score associated with specific symptom dimensions in first-episode psychosisSchizophr. Res.20171841161212791628710.1016/j.schres.2016.11.039 – reference: CuestaMJPeraltaVCurrent psychopathological issues in psychosis: Towards a phenome-wide scanning approachSchizophr. Bull.20083458718483012263244910.1093/schbul/sbn041 – reference: BucciPPersistent negative symptoms in recent-onset psychosis: Relationship to treatment response and psychosocial functioningEur. Neuropsychopharmacol.20203476861:CAS:528:DC%2BB3cXms1yit74%3D3229121010.1016/j.euroneuro.2020.03.010 – reference: Cannon-SpoorHEPotkinSGWyattRJMeasurement of premorbid adjustment in chronic schizophreniaSchizophr. Bull.198284704841:STN:280:DyaL3s%2FktFWjsw%3D%3D713489110.1093/schbul/8.3.470 – reference: MucciAFactors associated with real-life functioning in persons with schizophrenia in a 4-year follow-up study of the Italian network for research on psychosesJAMA Psychiatry2021785505593356607110.1001/jamapsychiatry.2020.4614 – reference: GeeBHodgekinsJFowlerDThe course of negative symptom in first episode psychosis and the relationship with social recoverySchizophr. Res.20161741651712713191210.1016/j.schres.2016.04.017 – reference: GalderisiSThe interplay among psychopathology, personal resources, context-related factors and real-life functioning in schizophrenia: Stability in relationships after 4 years and differences in network structure between recovered and non-recovered patientsWorld Psychiatry202019819131922687695354410.1002/wps.20700 – reference: NuechterleinKHIdentification of separable cognitive factors in schizophreniaSchizophr. Res.20047229391553140510.1016/j.schres.2004.09.007 – reference: StefanisNCHanssenMSmirnisNKEvidence that three dimensions of psychosis have a distribution in the general populationPsychol. Med.2002323471:STN:280:DC%2BD387jtVyhsw%3D%3D1186632710.1017/S0033291701005141 – reference: KaySRFiszbeinAOplerLAThe positive and negative syndrome scale (PANSS) for schizophreniaSchizophr. Bull.1987132612761:STN:280:DyaL2s3ptF2huw%3D%3D361651810.1093/schbul/13.2.261 – reference: GalderisiSEPA guidance on assessment of negative symptoms in schizophreniaEur. Psychiatry202164e231:STN:280:DC%2BB3snltlWruw%3D%3D33597064808020710.1192/j.eurpsy.2021.11 – reference: JonasKGSchizophrenia polygenic risk score and 20-year course of illness in psychotic disordersTransl. Psychiatry2019930031727878685616810.1038/s41398-019-0612-5 – reference: KendlerKSLiebermanJAWalshDThe structured interview for schizotypy (SIS): A preliminary reportSchizophr. Bull.1989155595711:STN:280:DyaK3c7mtFyqtQ%3D%3D262343810.1093/schbul/15.4.559 – reference: KernRSNuechterleinKHGreenMFThe MATRICS consensus cognitive battery, part 2: Co-norming and standardizationAm. J. Psychiatry20081652142201817201810.1176/appi.ajp.2007.07010043 – reference: SolbergDKBentsenHRefsumHAndreassenOALipid profiles in schizophrenia associated with clinical traits: A five year follow-up studyBMC Psychiatry20161629927562545500042310.1186/s12888-016-1006-3 – reference: NuechterleinKHGreenMFKernRSThe MATRICS consensus cognitive battery, part 1: Test selection, reliability, and validityAm. J. Psychiatry20081652032131817201910.1176/appi.ajp.2007.07010042 – reference: HedekerDA mixed-effects multinomial logistic regression modelStat. Med.200322143314461270460710.1002/sim.1522 – reference: HarveyPDStrassnigMPredicting the severity of everyday functional disability in people with schizophrenia: Cognitive deficits, functional capacity, symptoms, and health statusWorld Psychiatry201211737922654932336337610.1016/j.wpsyc.2012.05.004 – reference: VollemaMGOrmelJThe reliability of the structured interview for schizotypy-revisedSchizophr. Bull.2000266196291:STN:280:DC%2BD3cvktleisA%3D%3D1099340210.1093/oxfordjournals.schbul.a033482 – reference: BigdeliTPetersonRRipkeSGenome-wide association study of clinical features in the schizophrenia psychiatric genomics consortium: Confirmation of polygenic effect on negative symptomsBioRxiv201749161349 – reference: AustinSFMorsOBudtz-JørgensenELong-term trajectories of positive and negative symptoms in first episode psychosis: A 10 year follow-up study in the OPUS cohortSchizophr. Res.201516884912626529910.1016/j.schres.2015.07.021 – reference: JonesHJStergiakouliETanseyKEPhenotypic manifestation of genetic risk for schizophrenia during adolescence in the general populationJAMA Psychiatry20167322122826818099502474710.1001/jamapsychiatry.2015.3058 – reference: MistrySHarrisonJSmithDEscott-PriceVZammitSThe use of polygenic risk scores to identify phenotypes associated with genetic risk of schizophrenia: Systematic reviewSchizophr. Res.2018197282912950710.1016/j.schres.2017.10.037 – reference: GalderisiSEPA guidance on treatment of negative symptoms in schizophreniaEur. Psychiatry202164e211:STN:280:DC%2BB3sjot1KrsQ%3D%3D33726883805743710.1192/j.eurpsy.2021.13 – reference: AddingtonDAddingtonJSchisselBA depression rating scale for schizophrenicsSchizophr. Res.199032472511:STN:280:DyaK3M7itVCltQ%3D%3D227898610.1016/0920-9964(90)90005-R – reference: StiekemaAPIslamMALiemburgEJLong-term course of negative symptom subdomains and relationship with outcome in patients with a psychotic disorderSchizophr. Res.20171931732864891510.1016/j.schres.2017.06.024 – reference: VollemaMGSitskoornMMAppelsMCMKahnRSDoes the schizotypal personality questionnaire reflect the biological–genetic vulnerability to schizophrenia?Schizophr. Res.20025439451:STN:280:DC%2BD387itVahtQ%3D%3D1185397710.1016/S0920-9964(01)00350-4 – reference: XavierRMDunganJRKeefeRSEVorderstrasseAPolygenic signal for symptom dimensions and cognitive performance in patients with chronic schizophreniaSchizophr. Res. Cogn.201812111929552508585227910.1016/j.scog.2018.01.001 – reference: DasSForerLSchönherrSNext-generation genotype imputation service and methodsNat. Genet.20164812841:CAS:528:DC%2BC28XhsVWksL%2FK27571263515783610.1038/ng.3656 – volume: 49 start-page: 615 year: 1992 ident: 36235_CR33 publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.1992.01820080023004 – volume: 81 start-page: 559 year: 2007 ident: 36235_CR52 publication-title: Am. J. Hum. Genet. doi: 10.1086/519795 – volume: 5 start-page: 664 year: 2018 ident: 36235_CR38 publication-title: Lancet Psychiatry doi: 10.1016/S2215-0366(18)30050-6 – volume: 130 start-page: 11 year: 2011 ident: 36235_CR21 publication-title: Schizophr. Res. doi: 10.1016/j.schres.2011.03.015 – volume: 34 start-page: 587 year: 2008 ident: 36235_CR13 publication-title: Schizophr. Bull. doi: 10.1093/schbul/sbn041 – volume: 137 start-page: 246 year: 2012 ident: 36235_CR37 publication-title: Schizophr. Res. doi: 10.1016/j.schres.2012.01.031 – volume: 22 start-page: 1433 year: 2003 ident: 36235_CR57 publication-title: Stat. Med. doi: 10.1002/sim.1522 – volume: 114 start-page: 55 year: 2006 ident: 36235_CR45 publication-title: Acta Psychiatr. Scand. doi: 10.1111/j.1600-0447.2005.00741.x – volume: 12 start-page: 11 year: 2018 ident: 36235_CR29 publication-title: Schizophr. Res. Cogn. doi: 10.1016/j.scog.2018.01.001 – volume: 26 start-page: 619 year: 2000 ident: 36235_CR39 publication-title: Schizophr. Bull. doi: 10.1093/oxfordjournals.schbul.a033482 – volume: 32 start-page: 347 year: 2002 ident: 36235_CR46 publication-title: Psychol. Med. doi: 10.1017/S0033291701005141 – volume-title: Diagnostic and Statistical Manual of Mental Disorders: DSM-5 year: 2013 ident: 36235_CR1 doi: 10.1176/appi.books.9780890425596 – volume: 78 start-page: 550 year: 2021 ident: 36235_CR7 publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2020.4614 – volume: 54 start-page: 39 year: 2002 ident: 36235_CR40 publication-title: Schizophr. Res. doi: 10.1016/S0920-9964(01)00350-4 – volume: 3 start-page: 247 year: 1990 ident: 36235_CR47 publication-title: Schizophr. Res. doi: 10.1016/0920-9964(90)90005-R – volume: 15 start-page: 559 year: 1989 ident: 36235_CR41 publication-title: Schizophr. Bull. doi: 10.1093/schbul/15.4.559 – volume: 16 start-page: 299 year: 2016 ident: 36235_CR22 publication-title: BMC Psychiatry doi: 10.1186/s12888-016-1006-3 – volume: 34 start-page: 335 year: 2010 ident: 36235_CR17 publication-title: Genet. Epidemiol. doi: 10.1002/gepi.20486 – volume: 174 start-page: 165 year: 2016 ident: 36235_CR10 publication-title: Schizophr. Res. doi: 10.1016/j.schres.2016.04.017 – volume: 48 start-page: 1284 year: 2016 ident: 36235_CR53 publication-title: Nat. Genet. doi: 10.1038/ng.3656 – year: 2020 ident: 36235_CR44 publication-title: Schizophr. Res. doi: 10.1016/j.schres.2020.05.020 – volume: 7 start-page: e37852 year: 2012 ident: 36235_CR30 publication-title: PLoS ONE doi: 10.1371/journal.pone.0037852 – volume: 73 start-page: 221 year: 2016 ident: 36235_CR20 publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2015.3058 – volume: 8 start-page: 470 year: 1982 ident: 36235_CR48 publication-title: Schizophr. Bull. doi: 10.1093/schbul/8.3.470 – volume: 157 start-page: 853 year: 1990 ident: 36235_CR50 publication-title: Br. J. Psychiatry doi: 10.1192/bjp.157.6.853 – volume: 75 start-page: 396 year: 2018 ident: 36235_CR6 publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2017.4607 – volume: 28 start-page: 551 year: 1998 ident: 36235_CR49 publication-title: Psychol. Med. doi: 10.1017/S0033291798006667 – volume: 604 start-page: 502 year: 2022 ident: 36235_CR54 publication-title: Nature doi: 10.1038/s41586-022-04434-5 – volume: 165 start-page: 214 year: 2008 ident: 36235_CR27 publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2007.07010043 – volume: 9 start-page: 300 year: 2019 ident: 36235_CR25 publication-title: Transl. Psychiatry doi: 10.1038/s41398-019-0612-5 – volume: 64 start-page: e23 year: 2021 ident: 36235_CR36 publication-title: Eur. Psychiatry doi: 10.1192/j.eurpsy.2021.11 – volume: 184 start-page: 116 year: 2017 ident: 36235_CR18 publication-title: Schizophr. Res. doi: 10.1016/j.schres.2016.11.039 – volume: 34 start-page: 468 year: 2010 ident: 36235_CR14 publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2009.09.004 – volume: 169 start-page: 1309 year: 2012 ident: 36235_CR19 publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2012.12020218 – volume: 72 start-page: 29 year: 2004 ident: 36235_CR43 publication-title: Schizophr. Res. doi: 10.1016/j.schres.2004.09.007 – volume: 21 start-page: 340 year: 2011 ident: 36235_CR11 publication-title: Curr. Opin. Genet. Dev. doi: 10.1016/j.gde.2011.02.003 – volume: 13 start-page: 261 year: 1987 ident: 36235_CR35 publication-title: Schizophr. Bull. doi: 10.1093/schbul/13.2.261 – volume: 49 start-page: 161349 year: 2017 ident: 36235_CR32 publication-title: BioRxiv – volume: 168 start-page: 84 year: 2015 ident: 36235_CR16 publication-title: Schizophr. Res. doi: 10.1016/j.schres.2015.07.021 – volume: 29 start-page: 374 year: 2001 ident: 36235_CR55 publication-title: Sociol. Methods Res. doi: 10.1177/0049124101029003005 – volume: 91 start-page: 1 year: 2016 ident: 36235_CR31 publication-title: Curr. Protoc. Hum. Genet. – volume: 197 start-page: 2 year: 2018 ident: 36235_CR26 publication-title: Schizophr. Res. doi: 10.1016/j.schres.2017.10.037 – volume: 10 start-page: 1 year: 2020 ident: 36235_CR23 publication-title: Transl. Psychiatry doi: 10.1038/s41398-020-00919-x – volume: 21 start-page: 205 year: 2012 ident: 36235_CR34 publication-title: Int. J. Methods Psychiatr. Res. doi: 10.1002/mpr.1352 – volume: 12 start-page: e0187141 year: 2017 ident: 36235_CR56 publication-title: PLoS ONE doi: 10.1371/journal.pone.0187141 – volume: 11 start-page: 73 year: 2012 ident: 36235_CR3 publication-title: World Psychiatry doi: 10.1016/j.wpsyc.2012.05.004 – volume: 19 start-page: 559 year: 2017 ident: 36235_CR24 publication-title: Biol. Res. Nurs. doi: 10.1177/1099800417715907 – volume: 19 start-page: 81 year: 2020 ident: 36235_CR5 publication-title: World Psychiatry doi: 10.1002/wps.20700 – volume: 13 start-page: 1 year: 2013 ident: 36235_CR12 publication-title: BMC Psychiatry doi: 10.1186/1471-244X-13-320 – volume: 34 start-page: 76 year: 2020 ident: 36235_CR8 publication-title: Eur. Neuropsychopharmacol. doi: 10.1016/j.euroneuro.2020.03.010 – volume: 204 start-page: 58 year: 2019 ident: 36235_CR15 publication-title: Schizophr. Res. doi: 10.1016/j.schres.2018.08.018 – volume: 193 start-page: 173 year: 2017 ident: 36235_CR2 publication-title: Schizophr. Res. doi: 10.1016/j.schres.2017.06.024 – volume: 8 start-page: 1 year: 2018 ident: 36235_CR28 publication-title: Transl. Psychiatry doi: 10.1038/s41398-018-0204-9 – volume: 36 start-page: 267 year: 1995 ident: 36235_CR51 publication-title: Psychosomatics doi: 10.1016/S0033-3182(95)71666-8 – volume: 64 start-page: e21 year: 2021 ident: 36235_CR9 publication-title: Eur. Psychiatry doi: 10.1192/j.eurpsy.2021.13 – volume: 165 start-page: 203 year: 2008 ident: 36235_CR42 publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2007.07010042 – volume: 13 start-page: 275 year: 2014 ident: 36235_CR4 publication-title: World Psychiatry doi: 10.1002/wps.20167 |
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| Title | Six-year trajectories and associated factors of positive and negative symptoms in schizophrenia patients, siblings, and controls: Genetic Risk and Outcome of Psychosis (GROUP) study |
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